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[Le Modafinil]

Le modafinil est un antagoniste des benzodiazépines. Le modafinil, la forme prodrogue synthétisée chimiquement du d-modafinil, un stimulant de type amphétamine, a été développé à l'origine pour le traitement de la narcolepsie. Le modafinil augmente l'éveil et la vigilance en se liant au récepteur de la dopamine D2. Le traitement au modafinil a augmenté le temps entre les épisodes de sommeil lorsque les souris seraient normalement au repos et ne dormaient pas. Il traverse la barrière hémato-encéphalique, mais pas le placenta. Le modafinil est un mélange de deux substances chimiques : le citrate de modafinil, un analogue du neurotransmetteur dopamine, et son métabolite actif, le N-desméthyl modafinil. C'est un analogue structurel de la dopamine. Le modafinil est disponible en tant que médicament générique aux États-Unis, au Canada, dans l'Union européenne et en Australie. Le modafinil est également utilisé pour traiter l'épilepsie partielle bénigne de l'enfance avec des pointes (les garçons atteints de cette maladie peuvent éprouver des épisodes de somnolence diurne excessive qui peuvent être traités avec le médicament). On pense que le modafinil augmente le temps passé éveillé et peut également augmenter le temps passé en sommeil NREM. Le modafinil a été initialement approuvé pour un usage médical par l'Agence européenne des médicaments en janvier 1994. modafinil vente Un autre essai clinique portant sur 12 patients atteints du trouble du sommeil connu sous le nom d'hypersomnie a révélé que plus de 10 mois de traitement avec 400 mg de modafinil pendant 90 jours étaient sans danger, mais que l'effet sur la somnolence était inférieur à celui observé avec l'amphétamine, un médicament stimulant. Les autres médicaments les plus couramment utilisés dans cette catégorie comprennent le méthylphénidate (Ritalin), l'amphétamine (Adderall), la dextroamphétamine (Dexedrine) et la méthamphétamine (Desoxyn). Les doses habituelles d'autres médicaments sont souvent augmentées afin d'éviter les effets additifs des médicaments en association. D'autres effets secondaires comprennent une incidence rare d'effets secondaires cardiovasculaires. Pour que les gens utilisent en toute sécurité cette substance pour l'amélioration cognitive, ils doivent être bien tolérés au médicament et leur santé doit être surveillée de près. La posologie recommandée est de 100 à 200 mg pris environ 4 à 9 heures avant le coucher. Le modafinil est aussi efficace qu'une dose plus importante d'amphétamine (d'après une étude réalisée sur des sujets sains). Le modafinil peut potentiellement améliorer l'éveil et réduire les signes de somnolence. Disponibilité: Magasins : target="_blank">En savoir plus sur les médicaments spécialisés. C'est une drogue non amphétamine, sans effets euphorisants ou stimulants significatifs, mais avec la somnolence comme effet principal. La dose quotidienne initiale habituelle est de 100 mg pris le matin. Des publications ultérieures ont montré que ceux qui ont reçu du Modafinil ne présentaient pas une augmentation de l'éveil comme on le prétend, mais plutôt une somnolence similaire à celle des personnes recevant un placebo. Il a été développé par G. Un autre essai a trouvé une amélioration similaire de la vigilance et de l'éveil après 10 jours de traitement avec 150 mg chez les personnes souffrant de troubles du sommeil liés au travail posté.

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L'association du modafinil avec des stimulants tels que le mГ©thylphГ©nidate s'est avГ©rГ©e plus efficace que les stimulants seuls chez les patients atteints de narcolepsie. Le modafinil est un mГ©dicament expГ©rimental dont les propriГ©tГ©s pharmacologiques ont suscitГ© la controverse dans les communautГ©s scientifiques et profanes. Structurellement, il est classГ© comme un Г©ther non cyclique. Le modafinil est un mГ©lange racГ©mique de deux Г©nantiomГЁres, le R-(-)modafinil et le S-(+)modafinil, qui sont des images miroir l'un de l'autre. Trois grandes Г©tudes contrГґlГ©es randomisГ©es ont montrГ© que le modafinil Г©tait efficace pour amГ©liorer les symptГґmes du TDAH chez les enfants et les adultes. Le nom chimique du modafinil est ®-1-benzyl-2-mГ©thyl-1-phГ©nyl-Г©thylamine HCL. Le modafinil peut interagir avec plusieurs autres mГ©dicaments. Il a Г©tГ© dГ©montrГ© que le modafinil fonctionne mieux chez les personnes atteintes du syndrome des jambes sans repos ou d'affections similaires dues Г  une carence en dopamine. Certaines ordonnances sont combinГ©es avec d'autres mГ©dicaments, de sorte que le prix peut augmenter. Le modafinil est commercialisГ© sous le nom de marque Provigil par Cephalon, Inc. Il y a un manque de clartГ© dans les donnГ©es sur les risques relatifs de somnolence chez les personnes prenant du Modafinil. Il peut avoir des effets nГ©gatifs sur les paramГЁtres cardiovasculaires et la tension artГ©rielle. modafinil vente On pense que les nootropiques soutiennent l'activitГ© neuronale, ce qui amГ©liore la fonction cГ©rГ©brale de diverses maniГЁres. Il est Г©galement important de boire beaucoup d'eau pendant la journГ©e. Le modafinil est un antagoniste alpha-1, ce qui signifie qu'il bloque les rГ©cepteurs noradrГ©nergiques alpha-1 dans le cerveau. Fait intГ©ressant, contrairement Г  la sous-famille des psychostimulants stimulants (c'est-Г -dire la cocaГЇne, l'amphГ©tamine, la mГ©thamphГ©tamine et les substances apparentГ©es), il ne semble pas affecter les systГЁmes noradrГ©nergiques ou dopaminergiques. Le modafinil inhibe la formation de mГ©latonine, ce qui signifie qu'il est peu probable que les gens se rГ©veillent trop tГґt le matin. Le modafinil est vendu Г  la fois sous forme de comprimГ© et sous forme de gГ©lule Г  libГ©ration prolongГ©e. On ne sait pas quels sont ses effets exacts sur le corps, et certains d'entre eux n'ont pas Г©tГ© entiГЁrement compris. Cependant, les inhibiteurs de la MAO et d'autres inhibiteurs de la monoamine oxydase rГ©duisent la MAOA, entraГ®nant une rГ©duction des monoamines cГ©rГ©brales. Le modafinil augmente le flux sanguin vers le cerveau et le cЕ“ur, mais diminue le flux sanguin dans d'autres organes et dans la peau. AprГЁs l'arrГЄt de l'utilisation du modafinil, il faut gГ©nГ©ralement 3 semaines ou plus pour que les avantages se dissipent et que le risque de dГ©pendance et d'accoutumance rГ©apparaisse. Pour une pilule de 150 mg, c'est la quantitГ© qui serait prise en deux doses prises Г  environ une heure d'intervalle.

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