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Le modafinil est Г©galement disponible sous forme de solution et peut ГЄtre administrГ© par voie orale, via un spray nasal, par voie intraveineuse et via un implant sous la peau. La demi-vie du N-DM-modafinil est d'environ 30 minutes chez les personnes de plus de 18 ans. Il est dГ©conseillГ© aux femmes enceintes. Cela peut amГ©liorer les performances de travail et de conduite. Une fois liГ©, le transporteur de la sГ©rotonine est capable de se lier au site actif et d'empГЄcher la sГ©rotonine de se lier. Son efficacitГ© dans le traitement du DSPS est controversГ©e. Le modafinil est utilisГ© pour le traitement de la somnolence excessive, ou somnolence diurne, dans la narcolepsie. Le modafinil n'a pas Г©tГ© approuvГ© pour une utilisation dans le traitement de la schizophrГ©nie. Un jury a conclu que le fabricant, Mitsubishi Chemical, n'avait pas averti que le modafinil pouvait rendre l'enfant hyperactif et qu'il avait peut-ГЄtre endommagГ© son cerveau. Une Г©tude a rГ©vГ©lГ© que les gГЁnes d'horloge Per1, Per2, Bmal1, Cry1 et Rev-erbОІ n'Г©taient pas significativement affectГ©s par le modafinil, Per2 augmentant en fait ; une explication possible de cette dГ©couverte a Г©tГ© suggГ©rГ©e par le fait que la dopamine et la sГ©rotonine, Г©galement impliquГ©es dans le sommeil, rГ©gulent le gГЁne Per2. D'autres effets secondaires incluent des troubles du sommeil, une bouche sГЁche, un nez gonflГ©, une dГ©shydratation, une diarrhГ©e, une diminution de l'appГ©tit, des nausГ©es, des vomissements, de la constipation, de l'acnГ© et des dГ©mangeaisons.
ou acheter modafinil Il a été développé pour la première fois dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon. La posologie la plus courante est de 200 mg pris une heure avant le coucher. Il est disponible en tant que médicament générique. Le modafinil est un médicament stimulant le cerveau, apparenté à l'amphétamine. L'effet du modafinil sur les voies sérotoninergiques est bloqué par un traitement combiné par un inhibiteur de la recapture de la sérotonine et de la noradrénaline (IRSN) (par exemple la venlafaxine). Il n'est pas clair si cet effet est seul responsable de l'activation du cerveau ou si certains des effets sont le résultat de l'augmentation des niveaux de dopamine et de noradrénaline en raison du médicament. Certains magasins vendent la prescription à un prix régulier. Le modafinil est pris par voie orale et pris 20 minutes avant de dormir ou dans le cadre d'un régime chronométré, selon l'affection traitée. Le modafinil a été revendiqué comme étant utile pour le trouble déficitaire de l'attention avec hyperactivité (TDAH), en améliorant le contrôle des impulsions, la concentration et la mémoire à court terme chez les enfants. net. Il a été proposé de fonctionner de manière similaire à la caféine chez l'homme en se liant aux récepteurs de l'adénosine, en bloquant la liaison de l'adénosine et en augmentant ainsi les niveaux de dopamine, un neurotransmetteur. Le modafinil est un médicament stimulant sur ordonnance utilisé pour aider les gens à rester éveillés. Il n'est pas clair si l'utilisation pendant la grossesse est sans danger. Ils ont depuis été remplacés par Portola Pharmaceuticals, qui a produit une version du médicament sous le nom de marque Naromine.
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