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Le modafinil, connu sous le nom de Provigil 200 mg, est utilisé pour le traitement de la somnolence excessive associée à la narcolepsie, aux troubles du sommeil liés au travail posté et à d'autres troubles. Ceci est dû à une biodisponibilité relativement élevée. De nombreux facteurs affectent l'efficacité et la durée d'action du modafinil. Dans certains pays, le modafinil est disponible comme traitement de la narcolepsie. Les énantiomères du modafinil agissent sur les mêmes récepteurs, de sorte que chaque énantiomère peut se lier avec une égale affinité au même récepteur. Le modafinil s'est avéré être un antagoniste compétitif sélectif des récepteurs de l'adénosine chimique favorisant l'éveil, le même type de mécanisme que celui utilisé par les benzodiazépines. Le modafinil appartient à la classe des éthylamines et est légalement commercialisé aux États-Unis sous le nom de Provigil. Il a également été suggéré que le modafinil fonctionne comme un agent modulateur du glutamate. Le modafinil a également été proposé comme activateur cognitif. Il n'y a pas suffisamment de preuves pour montrer que le modafinil est efficace pour améliorer les performances cognitives humaines, bien que certaines études animales suggèrent qu'il pourrait améliorer les performances cognitives. Le modafinil a été développé à l'origine par le neuroscientifique français Michel Jouvet et les laboratoires Lafon, en utilisant des analogues chimiques synthétiques, et a été approuvé pour un usage médical aux États-Unis en 1998. modafinil france acheter Le modafinil est disponible sous forme de pilule, de dose et d'injection. Les personnes prenant du modafinil peuvent atteindre un état de veille normal, ce qui peut être bénéfique pour ceux qui ont un travail qui nécessite une vigilance constante. Les effets secondaires du modafinil sont considérés comme légers. Ils disparaissent une fois que vous prenez le médicament. Comme l'amphétamine, le modafinil agit également sur le transporteur de la dopamine dans le cerveau, augmentant la disponibilité de la dopamine au niveau de ses récepteurs. L'utilisation hors AMM comprend, mais sans s'y limiter, le traitement de la narcolepsie et de la somnolence diurne excessive (EDS) associée à l'apnée du sommeil. En raison de ses propriétés stimulantes, le modafinil provoque une augmentation de la pression artérielle, de la fréquence cardiaque et de la glycémie. Le modafinil est bien toléré. Il est approuvé comme traitement de la narcolepsie avec ou sans cataplexie, chez l'adulte et l'enfant, ainsi que des troubles du sommeil liés au travail posté. C'est un mélange racémique de dextro- et lévo-modafinil. Il peut également être utilisé pour traiter la fatigue causée par l'apnée obstructive du sommeil et est également couramment utilisé comme aide à la perte de poids et pour aider à maintenir la vigilance chez les personnes souffrant de divers types de lésions cérébrales. Le modafinil n'est pas recommandé pendant la grossesse. En cas d'utilisation prolongée, le médicament peut empêcher l'organisme d'apprendre à s'adapter aux changements de rythme circadien. Certains patients atteints de TDAH ont montré une amélioration de l'attention et du temps de réponse lors de l'utilisation du modafinil.

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Le modafinil peut Г©galement provoquer des Г©tourdissements ou des Г©tourdissements chez certaines personnes. Les versions de rue et gГ©nГ©riques du modafinil sont les mГЄmes. Aux Г‰tats-Unis, il est classГ© comme un mГ©dicament dГ©livrГ© uniquement sur ordonnance. Le modafinil a Г©galement Г©tГ© utilisГ© pour traiter les travailleurs postГ©s qui Г©prouvent une somnolence excessive au travail. Il a Г©galement Г©tГ© suggГ©rГ© que le modafinil pourrait avoir des effets d'amГ©lioration cognitive, ainsi qu'attГ©nuer les symptГґmes de la dГ©pression, du trouble dГ©ficitaire de l'attention avec hyperactivitГ© (TDAH), du trouble bipolaire et d'autres maladies mentales. Au Royaume-Uni, il est produit par GlaxoSmithKline, une sociГ©tГ© pharmaceutique basГ©e au Royaume-Uni. Le mГ©decin prescrira la dose optimale en fonction des besoins individuels. Le modafinil est disponible en tant que mГ©dicament gГ©nГ©rique. Il ne semble pas provoquer d'allergie alimentaire ou alcoolique et il ne semble pas augmenter la tension artГ©rielle ou rendre les patients plus sensibles aux infections. L'essai comprenait 218 patients qui ne rГ©pondaient pas Г  deux Г  quatre mois de thГ©rapie comportementale. Le modafinil est indiquГ© pour le traitement de la somnolence associГ©e aux troubles du sommeil narcolepsie, trouble du sommeil liГ© au travail postГ© et apnГ©e obstructive du sommeil. Le modafinil est utilisГ© seul ou en association avec des traitements approuvГ©s pour l'insomnie. modafinil france acheter Un dГ©rivГ© du modafinil est le CRL-3995. Le mГ©dicament doit ГЄtre pris au moins 30 minutes avant le petit-dГ©jeuner. Il est disponible en tant que mГ©dicament gГ©nГ©rique. Le modafinil peut Г©galement agir comme antagoniste des rГ©cepteurs de l'adГ©nosine. Il est utilisГ© pour traiter les adultes et les adolescents qui souffrent de somnolence diurne excessive liГ©e Г  la narcolepsie, Г  l'apnГ©e obstructive du sommeil (AOS), au travail postГ© ou Г  l'hypersomnie idiopathique. Le modafinil est un activateur cognitif et un mГ©dicament anti-anxiГ©tГ©. Le modafinil n'est pas approuvГ© pour le traitement de la fatigue associГ©e Г  des conditions mГ©dicales chroniques. Une dose supГ©rieure Г  la dose recommandГ©e peut entraГ®ner des effets indГ©sirables importants. Modafinil agit pour augmenter la libГ©ration d'acГ©tylcholine. Le modafinil est Г©galement utilisГ© pour favoriser l'Г©veil et la performance chez les personnes qui ne peuvent pas dormir la nuit en raison d'une somnolence diurne excessive, d'un travail postГ© ou pour prГ©venir leur besoin d'opioГЇdes pour dormir.

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