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Il est généralement pris sous forme de pilule trois fois par jour, ou sous forme de comprimé sublingual trois fois par jour, à une dose de 25 à 100 mg par jour, bien que des doses aussi élevées que 200 mg par jour aient été utilisées. Le modafinil ralentit la recapture de la dopamine en inhibant la recapture de la dopamine. L'alcool peut également augmenter les effets secondaires du médicament. Le modafinil est un stimulant du système nerveux central qui agit en arrêtant le cycle du sommeil et en permettant au corps de rester éveillé pendant une période prolongée. Le modafinil, également connu sous les noms de marque Provigil et Alertec, est un stimulant à action centrale. Le médicament est principalement disponible sous forme de comprimés à des doses de 100 mg, 200 mg ou 300 mg. La dose approuvée de modafinil est de 200 mg. Le modafinil pourrait également être utile dans le traitement d'une affection appelée hypersomnie ; cependant, il n'est pas approuvé pour cette utilisation. Comme le Ritalin, le modafinil semble augmenter les niveaux de dopamine dans le cerveau, stimulant l'éveil. Il agit comme un inhibiteur de l'enzyme monoamine oxydase A (MAOA), qui interfère avec un neurotransmetteur, la sérotonine, et de l'enzyme monoamine oxydase B (MAOB), qui interfère avec un neurotransmetteur, la noradrénaline. Le modafinil est utilisé dans le traitement de la somnolence excessive due à la narcolepsie et aux troubles du sommeil liés au travail posté et pour augmenter l'éveil chez les personnes souffrant d'apnée obstructive du sommeil. Le modafinil améliore l'éveil et améliore les performances cognitives, mais n'est pas un traitement de la dépendance. Le modafinil est approuvé pour le traitement de la narcolepsie, des troubles du sommeil liés au travail posté et de l'apnée obstructive du sommeil (OSA). Le modafinil a été approuvé pour un usage médical par la Food and Drug Administration (FDA) française en 1994, et la FDA des États-Unis l'a approuvé pour un usage médical en 1998. ou acheter modafinil com, est utilisé pour traiter la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée du sommeil. En 2010, le modafinil a été approuvé par la FDA pour le traitement des troubles du sommeil liés au travail posté, mais pas pour la narcolepsie. Le modafinil est connu pour augmenter le risque de schizophrénie et de trouble bipolaire. Cette action entraîne à son tour une diminution de la neurotransmission du glutamate due à l'inhibition des récepteurs de l'adénosine A2. Le modafinil est également approuvé comme médicament expérimental pour le TDAH et d'autres indications neuropsychiatriques. Il a également été utilisé dans des essais cliniques pour étudier ses propriétés potentielles d'amélioration cognitive chez les personnes atteintes de la maladie d'Alzheimer. Le modafinil a vu une utilisation limitée pour le traitement du trouble déficitaire de l'attention/hyperactivité, les effets secondaires en font un choix peu pratique. Le modafinil 200 mg a augmenté la concentration plasmatique moyenne de modafinil d'environ 150 % par rapport au placebo. Le modafinil est un antagoniste des récepteurs alpha 1-adrénergiques et inhibe également la recapture de la sérotonine. Dans des études animales utilisant des primates, il a été démontré que le modafinil augmente la dopamine dans le cerveau. Par exemple, la prescription de modafinil doit être accompagnée de précautions quant au risque de syndrome malin des neuroleptiques. Le modafinil procure une sensation d'éveil aux personnes atteintes de narcolepsie et d'apnée du sommeil. Dans les formes non saisonnières, il est souvent administré en association avec des antidépresseurs. Le modafinil semble avoir peu d'effets secondaires, les effets secondaires les plus fréquemment signalés étant les maux de tête, les nausées et la somnolence.
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