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Il a Г©tГ© utilisГ© Г des fins rГ©crГ©atives comme amГ©lioration cognitive. C'Г©tait le premier d'une nouvelle gГ©nГ©ration de stimulants qui sont apparus pour la premiГЁre fois Г la fin des annГ©es 1980, tels que le mГ©thylphГ©nidate et le dexmГ©thylphГ©nidate (Ritalin), et plus tard les sels d'amphГ©tamine, qui comprennent la dextroamphГ©tamine, le sulfate de dextroamphГ©tamine et la mГ©thamphГ©tamine. Le modafinil est un stimulant du systГЁme nerveux central. Le modafinil peut ГЄtre pris avec ou sans nourriture, n'a pas d'interactions pharmacocinГ©tiques significatives et n'est pas associГ© Г des interactions mГ©dicamenteuses significatives. Il est souvent utilisГ© pour rГ©duire la somnolence diurne chez les personnes souffrant d'apnГ©e obstructive du sommeil. Un autre essai contrГґlГ© chez 12 volontaires sains a rГ©vГ©lГ© que 200 mg Г©taient tout aussi efficaces. Le modafinil est un agent spГ©cifique favorisant l'Г©veil utilisГ© pour traiter la somnolence diurne excessive chez les personnes souffrant d'apnГ©e obstructive du sommeil. Il y a eu au moins une Г©tude sur la pharmacologie et la sГ©curitГ© du modafinil pour une utilisation hors AMM dans le contexte de l'amГ©lioration cognitive. Les gГ©lules de modafinil sont disponibles en 40 mg, 200 mg, 400 mg et 600 mg. Il a Г©tГ© dГ©montrГ© que le modafinil inhibe la libГ©ration d'oxyde nitrique et en prГ©sence d'oxyde nitrique in vitro. Modafinil Europe Le modafinil a Г©galement des effets inhibiteurs sur les cholinestГ©rases. Le modafinil antagonise Г©galement les effets favorisant le sommeil de la signalisation orexinergique et histaminergique. Le modafinil est un inhibiteur de l'acГ©tylcholinestГ©rase (AChE), une enzyme qui inhibe l'action des neurotransmetteurs tels que la dopamine et la sГ©rotonine. Les comprimГ©s de modafinil contiennent une forme Г libГ©ration prolongГ©e du mГ©dicament (120 mg, 200 mg et 400 mg), avec le mГЄme mГ©dicament, le modafinil, dans chaque comprimГ©. Chaque comprimГ© contient 100 mg de modafinil et 200 mg de cafГ©ine. Il n'y a pas de diffГ©rence d'efficacitГ© entre les deux Г©nantiomГЁres. Selon le NCBI, l'amГ©lioration cognitive peut ГЄtre attribuГ©e Г deux effets principaux : Le modafinil provoque de la somnolence chez les personnes qui en prennent. Les ingrГ©dients du modafinil varient en fonction des diffГ©rentes formes disponibles. Aucune interaction mГ©dicamenteuse n'a Г©tГ© signalГ©e avec Modafinil. Sa vente a Г©tГ© approuvГ©e aux Г‰tats-Unis en 1998. Le d et le l-thrГ©o-modafinil prГ©sentent une activitГ© pharmacodynamique dans les Г©tudes in vitro. Le nom de marque Provigil est le seul nom gГ©nГ©rique approuvГ© par la FDA aux Г‰tats-Unis.
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