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P. Le modafinil est un dérivé structurel de l'alfuzosine, un dérivé de la benzothiadiazine et un alpha-1 adrénergique non sélectif. Lundbeck. Le modafinil est utilisé pour la somnolence associée à la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. C'est le médicament le plus couramment prescrit utilisé à cette fin. Il bloque la recapture de la noradrénaline, ce qui peut également contribuer à sa capacité à favoriser l'éveil. En 1988, les laboratoires Jouvet et Lafon ont obtenu un brevet français pour l'utilisation du modafinil dans le traitement des troubles du sommeil dont la narcolepsie, ainsi que le trouble déficitaire de l'attention avec hyperactivité (TDAH), la somnolence diurne excessive et les troubles du travail posté. En raison de la classification de l'annexe IV de la FDA, le modafinil n'a pas été approuvé pour une utilisation en tant qu'amplificateur cognitif, bien qu'il soit utilisé comme traitement pour des troubles du sommeil spécifiques. Le médicament affecte les neurotransmetteurs du système nerveux central du cerveau et améliore la vigilance. À utiliser avec prudence chez les personnes atteintes de la maladie de Parkinson, d'hyperthyroïdie ou d'hypotension artérielle. et le médicament a montré une demi-vie légèrement plus longue (8 à 10 heures) que son métabolite actif. L'acide libre de modafinil est l'ingrédient actif de Provigil et il est plus difficile à trouver au Royaume-Uni et ailleurs.
Modalert Canada La structure cyclopyrrolone est l'un des principaux avantages du Modafinil. Il n'est pas recommandé chez les personnes souffrant d'arythmie, d'hypertension artérielle importante ou d'hypertrophie ventriculaire gauche. Le modafinil a été noté comme un activateur cognitif efficace, et certains produits d'amélioration cognitive ont été formulés avec l'utilisation du médicament comme ingrédient principal. Le modafinil peut augmenter la fréquence des selles, ce qui peut inclure des choses telles que des selles dures ou de la constipation, et peut provoquer une impaction (élimination difficile). Le modafinil semble avoir un effet similaire sur le fonctionnement de la dopamine dans le circuit de récompense du cerveau que la méthamphétamine. Le modafinil peut également diminuer la tension artérielle ou ralentir le rythme cardiaque. Ces résultats ont été confirmés par une étude indépendante de 24 heures en 1992 (Muroff et al. Il est déconseillé aux enfants, sauf s'il est prescrit par un médecin et suivi par un professionnel de la santé. Cette somnolence est une condition qui peut survenir lorsque vous dormez plus que d'habitude. Le modafinil est également disponible en comprimés de 250 mg et 400 mg. Il a été démontré que le modafinil agit en agissant sur les récepteurs de la dopamine dans le système nerveux central. Une étude de dosage du modafinil 400-800 mg a révélé qu'il était efficace pour augmenter le temps de réaction et "d'autres variables cognitives" telles que la mémoire et l'attention. Le modafinil est aussi appelé Provigil car il a été développé par une société française appelée Lafon. Le modafinil a l'avantage d'être utilisé dans un seul but, de sorte qu'un utilisateur ressentira peu d'effets secondaires en prenant simplement le médicament.
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