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#6
Cependant, il semble que le modafinil n'affecte que le sous-type du récepteur dopaminergique 2 (D2), qui n'est pas le même que le méthylphénidate, qui stimule les sous-types D2 et D3. Ce n'est pas un antidépresseur ni un médicament antipsychotique. Il est pris par la bouche. La demande française de brevet pour le modafinil a été déposée par les Laboratoires Jouvet et Lafon en janvier 1977, mais le brevet n'a été approuvé qu'en décembre 1979, en France. Il est également métabolisé par l'enzyme monoamine oxydase A (MAO-A). Aucun des participants n'a signalé d'effets indésirables cliniquement significatifs ou de fonctionnement anormal. Ceux-ci comprennent la congestion nasale, la vision floue, l'irritation des sinus, les problèmes sexuels, les maux de tête, les maux de dos, les étourdissements et la rougeur des yeux. Le modafinil est plus concentré et moins euphorique et est souvent pris pour augmenter la productivité. Ce médicament peut également augmenter ou diminuer la tension artérielle, la glycémie, la fréquence cardiaque et/ou d'autres aspects de la santé. Les comprimés enrobés de modafinil sont les plus efficaces, avec une biodisponibilité accrue à partir d'un pelliculage en raison d'un environnement à pH acide et d'une libération accrue du médicament. Il améliore l'éveil et l'activité et peut provoquer une légère euphorie. Son efficacité est similaire à celle des amphétamines, qui stimulent à la fois les systèmes noradrénergique et dopaminergique. Une découverte de Bailes et al. acheter modiodal Une dose unique et importante peut produire des effets secondaires pouvant durer jusqu'à quatre heures. Un petit nombre d'études de cas ont montré que le modafinil peut être efficace pour augmenter la vigilance et améliorer les performances au travail. Son effet précis sur le sommeil est inconnu et les effets secondaires peuvent inclure des étourdissements, des nausées, des maux de tête, de la somnolence, de la faiblesse et des changements d'humeur. Le modafinil n'est pas prescrit aux personnes atteintes du syndrome des jambes sans repos. Il n'est pas clair si l'utilisation pendant la grossesse est sans danger. Le modafinil semble réduire l'expérience de l'effort et de la fatigue tout en améliorant les fonctions cognitives chez les personnes en bonne santé, et ses effets semblent persister jusqu'à 24 heures. Il a été démontré que le modafinil a des effets particuliers sur les zones du cerveau qui sont particulièrement impliquées dans le cycle du sommeil. Il est utilisé pour traiter certains cas de narcolepsie et de troubles du sommeil liés au travail posté. Il semble avoir peu ou pas d'effet sur les niveaux de sérotonine (5HT) ou d'adénosine (AD). Au Royaume-Uni, le modafinil n'est approuvé que pour une utilisation dans le cadre d'un essai clinique et, en tant que tel, n'est pas disponible pour la recherche. Il contient les produits chimiques modafinil et adrafinil.

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#8
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#9
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#10
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