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Si vous vous sentez diffГ©rent pendant que vous prenez ce mГ©dicament, contactez votre mГ©decin. Il affecte l'Г©veil en se liant aux rГ©cepteurs de la dopamine dans le cerveau pour favoriser la libГ©ration de la dopamine, un neurotransmetteur. Dans certains pays, le nom de marque Modafinil est utilisГ© plus souvent que le mГ©dicament lui-mГЄme. Le Modafinil a Г©tГ© dГ©couvert par des scientifiques des Laboratoires Pierre Fabre. Les prestataires de soins de santГ© doivent vous surveiller pour dГ©tecter tout changement de comportement ou tout autre effet secondaire pendant le traitement. Le modafinil est un composГ© racГ©mique. Banich Г l'hГґpital McLean. Le modafinil est prescrit en France depuis 1994 et a Г©tГ© approuvГ© pour un usage mГ©dical aux Г‰tats-Unis en 1998. Il en rГ©sulte une concentration plus Г©levГ©e de dopamine dans le cerveau. Son efficacitГ© est similaire Г celle des amphГ©tamines, qui stimulent Г la fois les systГЁmes noradrГ©nergique et dopaminergique. Nootropique En Pharmacie Si vous utilisez 200 mg tous les deux jours, cela ne causera pas de problГЁmes. Le modafinil inhibe la recapture de la sГ©rotonine, de la dopamine et de la noradrГ©naline, qui sont libГ©rГ©es pendant le sommeil. de pointes (TdP, un trouble rare du rythme cardiaque irrГ©gulier) chez les personnes prenant du modafinil. Le modafinil est une В«substance activatriceВ» qui affecte le noyau tegmental dorsal du pont. Il n'y a pas de limite de temps spГ©cifique pour prendre les comprimГ©s, mais les intervalles habituels recommandГ©s entre les doses sont de 6 Г 9 heures. Le citrate de modafinil (ou modafinil HCl) peut ГЄtre pris sans tenir compte des repas et peut ГЄtre pris sous forme de comprimГ© ou de liquide, et sa nature IR signifie qu'il peut ГЄtre rapidement absorbГ© et commence Г agir peu de temps aprГЁs l'ingestion. Il fonctionne lorsqu'il est pris par voie orale ou intraveineuse, bien que le premier soit plus courant. Le modafinil n'accГ©lГЁre pas directement l'activitГ© motrice, mais il amГ©liore l'Г©veil, l'apprentissage, la mГ©moire, la motivation et l'efficacitГ© de l'attention et de la perspicacitГ©. Le modafinil augmente les niveaux de norГ©pinГ©phrine et de dopamine en inhibant la recapture de ces neurotransmetteurs et en dГ©clenchant la libГ©ration de sГ©rotonine par les terminaisons nerveuses. Des effets sur la dopamine dans le noyau accumbens, ainsi que dans le thalamus et l'hypothalamus ont Г©galement Г©tГ© signalГ©s. Le modafinil est gГ©nГ©ralement bien tolГ©rГ© et sans danger, avec des effets secondaires possibles, notamment des maux de tГЄte, des troubles du sommeil et des nausГ©es. Dans le traitement de la somnolence excessive, la posologie de modafinil utilisГ©e dГ©pend de la dose recommandГ©e de l'individu et du mГ©dicament. Le modafinil a Г©tГ© significativement plus efficace dans le traitement de la somnolence excessive que le placebo avec une diffГ©rence moyenne de 1,6 heures d'Г©veil supplГ©mentaire par jour (p Le mГ©canisme d'action exact du modafinil n'est pas compris, mais on pense qu'il agit en modulant le systГЁme sГ©rotoninergique, en stimulant la libГ©ration de noradrГ©naline, et peut-ГЄtre aussi les neurotransmetteurs dopamine et sГ©rotonine. Modalert est disponible au Royaume-Uni en tant que mГ©dicament en vente libre et en Inde sous le nom de Promodar. Il est disponible en tant que mГ©dicament gГ©nГ©rique.
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