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Le modafinil, comme de nombreux stimulants du SNC, peut provoquer de la confusion, de l'anxiété et des changements de comportement chez les patients qui ne le prennent pas pour la raison prescrite. Il est disponible sous forme de médicament sur ordonnance en Europe et aux États-Unis. Le modafinil peut créer une accoutumance et des effets addictifs ont été observés dans des études animales. Le modafinil agit en augmentant l'activité des neurotransmetteurs comme la dopamine, la noradrénaline et l'histamine. Des effets sur la dopamine dans le noyau accumbens, ainsi que dans le thalamus et l'hypothalamus ont également été signalés. Le principal mode d'action semble être un composé cérébral appelé acétylcholine et on pense qu'il fonctionne en remplaçant les niveaux de dopamine dans le cerveau qui sont naturellement élevés par les effets du sommeil. Le médicament est le métabolite actif du médicament d'ordonnance armodafinil et est donc appelé d-N-p-tyrosine. Le modafinil est un médicament sur ordonnance généralement pris avant le coucher par les personnes souffrant de somnolence diurne excessive. Le modafinil est une substance contrôlée aux États-Unis. Lundbeck et les Laboratoires de Lafon. Modafinil Sans Ordonnance Quebec De rares réactions dermatologiques graves peuvent survenir chez les personnes présentant des prédispositions génétiques et plus fréquemment chez les patients pédiatriques. Dans une deuxième étude multisite, les participants ont pris une seule dose de 10 mg de modafinil avant d'effectuer une série de différents tests cognitifs. Le mécanisme d'action du modafinil est largement inconnu, bien qu'il soit connu pour agir principalement sur le SNC et n'ait aucun effet secondaire stimulant connu. Pharmacologiquement, le modafinil est un promédicament du 2-[(diphénylméthyl)sulfinyl]acétyl naphtalène-2-ol, qui est chimiquement et thérapeutiquement identique au méthylphénidate. Le modafinil est un bipyridyle équilibré. L'affinité du modafinil pour le récepteur alpha-2 est plus élevée que pour le récepteur alpha-1. La même étude a révélé que le modafinil et un agoniste de la même classe de récepteurs qu'il stimule sont tout aussi efficaces pour améliorer l'éveil. Il peut être pris par voie orale, sous forme de pilule ou sous forme injectable. Son principal métabolite est formé par oxydation hépatique via le CYP2C19. Comme pour tous les médicaments, il est toujours conseillé d'informer un professionnel de la santé si vous êtes enceinte ou si vous allaitez. La durée habituelle du traitement est de 3 à 6 mois et peut être plus longue si nécessaire. Le modafinil, également connu sous le nom de d- ou l-modafinil, est un agoniste sélectif des récepteurs alpha-2 utilisé pour le traitement de la somnolence chez les personnes atteintes de narcolepsie ou de troubles du sommeil liés au travail posté. Sa formule chimique est C20H22N4O. Il existe également des liens vers plus d'informations sur le modafinil, y compris les doses, les effets secondaires, les interactions médicamenteuses et la disponibilité.
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