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Le modafinil a un effet stimulant, mais sans effet euphorisant. Les personnes ayant des problèmes cardiaques préexistants courent un risque accru d'avoir des problèmes cardiaques si elles utilisent le modafinil. Le modafinil doit être arrêté dès les premiers signes d'éruption cutanée ou de réactions similaires. La caféine interagit également avec le modafinil. On ne sait pas si le modafinil est sûr chez les personnes atteintes de certaines maladies cardiovasculaires telles que l'hyperthyroïdie, l'insuffisance cardiaque ou les arythmies, ou s'il doit être arrêté chez les personnes qui subissent une intervention médicale impliquant une ponction, une incision ou un cathétérisme à long terme. La demi-vie du modafinil est plus longue que celle des amphétamines, ce qui lui permet de rester plus longtemps dans le cerveau. Le modafinil est un stimulant du système nerveux central. L'amélioration de la cognition avec le modafinil est généralement liée à la vigilance, l'attention, la motivation, la mémoire de travail, les performances psychomotrices, l'apprentissage et la mémoire, et l'intelligence. Modafinil a été initialement développé par la société pharmaceutique française Laboratoires Lafon, mais en 1994, leur produit a été poursuivi pour rupture de contrat aux États-Unis après qu'il a été allégué qu'ils avaient volé l'idée de Michel Jouvet, le neuroscientifique français qui a découvert la substance dans le années 1970. Il est considéré comme un inhibiteur partiel de la neurotransmission de la dopamine et est également un agoniste allostérique du récepteur alpha-2A. Le modafinil est un stimulant du système nerveux central qui active les récepteurs de la dopamine. L'ingrédient actif du produit générique est le même que celui du R-Modafinil. Il est également parfois utilisé pour traiter le trouble déficitaire de l'attention (TDAH), ainsi que d'autres conditions. Le modafinil est répertorié comme un médicament de grossesse de catégorie C par la FDA, ce qui indique qu'il existe un risque de nuire au fœtus s'il est pris pendant la grossesse. Le modafinil se présente sous la forme de comprimés de 100 mg, 200 mg et 300 mg, ainsi que de suspension buvable de 100 mg et 200 mg.
Modafinil Maroc Prix Le mГ©dicament augmente la libГ©ration de dopamine dans la rГ©gion tegmentale ventrale et le noyau accumbens, qui sont reliГ©s au noyau caudatus. L'isomГ©rie est importante car on sait que l'isomГЁre dextro a une plus grande affinitГ© pour le rГ©cepteur 5-HT2C. Le modafinil ne se dissout pas et ne se disperse pas Г des concentrations de 0,5 % et plus. Une Г©tude sur des souris gГ©nГ©tiquement modifiГ©es a suggГ©rГ© que le modafinil pourrait amГ©liorer l'activitГ© de certaines zones du cerveau liГ©es Г la somnolence. Il est Г©galement contre-indiquГ© chez les enfants de moins de 3 ans. Le modafinil, Г©galement appelГ© Provigil, est l'ingrГ©dient actif d'une variГ©tГ© de mГ©dicaments en vente libre. Provigil est un nom de marque de modafinil. Les rГ©cepteurs alpha-1 et alpha-2 sont appelГ©s rГ©cepteurs alpha-1 et alpha-2. Le modafinil est un mГ©dicament d'ordonnance dГ©veloppГ© dans les annГ©es 1970 pour traiter la narcolepsie. Environ 40 % de la dose est excrГ©tГ©e sous forme inchangГ©e dans l'urine et 38 % sous forme de mГ©tabolites dans l'urine.
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Le mГ©canisme d'action exact du modafinil n'a pas Г©tГ© entiГЁrement Г©tabli. La seule indication approuvГ©e pour l'utilisation du modafinil aux Г‰tats-Unis est la narcolepsie. Dans le cas des patients souffrant de troubles du sommeil, le Modafinil entraГ®ne des amГ©liorations des mesures objectives et subjectives de la qualitГ© et de la durГ©e du sommeil chez les patients souffrant de troubles centraux. Il existe deux principaux types de modafinil ; le citrate de modafinil et l'ingrГ©dient actif modafinil non modifiГ©. Il a Г©tГ© dГ©veloppГ© comme agent induisant l'Г©veil pour le dГ©calage horaire et le travail postГ©. Le mГ©dicament est fabriquГ© par Cephalon, une filiale de la sociГ©tГ© Johnson & Johnson. Le modafinil est gГ©nГ©ralement considГ©rГ© comme sГ»r, aucune dose n'Г©tant considГ©rГ©e comme trop Г©levГ©e. Il peut ГЄtre pris jusqu'Г 8 heures avant d'aller dormir, mais ne doit pas ГЄtre pris plus d'une fois par jour. Il peut ГЄtre achetГ© pour aussi peu que 13 $, qui Г©tait de 18 $ en 2015. Le modafinil est utilisГ© pour traiter la somnolence diurne excessive (EDS) due Г l'apnГ©e obstructive du sommeil, Г la narcolepsie et aux troubles du travail postГ©. Il passe principalement dans l'urine et est excrГ©tГ© principalement sous forme inchangГ©e.
Modafinil Maroc Prix Il est pris par voie orale et est bien toléré, avec des effets secondaires possibles, notamment des maux de tête, des troubles du sommeil et des nausées. Le modafinil semble être sans danger pour les personnes souffrant de troubles respiratoires du sommeil de longue date dus au syndrome de résistance des voies respiratoires supérieures. Il peut provoquer des modifications inhabituelles de la peau, telles qu'un gonflement, une décoloration ou une rougeur de la peau, une sensibilité au soleil ou d'autres affections cutanées. C'est un dérivé expérimental de l'acide acétylphénylacétique qui a été signalé pour la première fois comme métabolite de la caféine en 1958. On pense que les stimulants addictifs à courte durée d'action et non de type amphétamine ont un mécanisme d'action similaire à celui de l'amphétamine. En fait, le modafinil est le seul stimulant du système nerveux central qui a été démontré dans des essais contrôlés randomisés pour augmenter de manière fiable l'éveil, sans produire d'euphorie ou d'autres effets secondaires indésirables. Il est recommandé aux personnes prenant du Modafinil de constater une amélioration significative de leur capacité à rester éveillé. Le modafinil est inactivé par l'exposition à la lumière, il doit donc être conservé dans l'obscurité, à l'abri de la lumière du soleil. Le R-modafinil est actif, tandis que le S-modafinil est inactif. Les participants à l'étude qui ont reçu 200 mg de modafinil pris avant le coucher ont pu rester éveillés près de 9 heures après avoir pris le médicament. Bien que l'avertissement du fabricant concernant un risque accru d'effets secondaires tels que l'anxiété, la nervosité et les maux de tête n'ait pas été étayé, le modafinil peut augmenter le risque de convulsions chez les personnes ayant des antécédents de troubles épileptiques. De plus, le modafinil augmente la dopamine et la sérotonine dans le liquide céphalo-rachidien et augmente leurs niveaux dans le cerveau.
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