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Le modafinil est une prodrogue qui subit une hydroxylation hГ©patique en acide modafinil, un mГ©tabolite actif. La dose recommandГ©e de Modafinil pour les travailleurs postГ©s est de 150 Г 300 mg par jour. Le modafinil est un mГ©dicament sur ordonnance, pas une drogue rГ©crГ©ative. Le modafinil est administrГ© par voie orale. Le modafinil agit Г©galement comme un antagoniste non sГ©lectif de l'histamine H1 et H2 rГ©cepteurs. En plus de ses indications approuvГ©es, Modafinil est approuvГ© dans de nombreux autres pays pour le traitement de la somnolence diurne excessive rГ©sultant d'une condition mГ©dicale. Il a Г©tГ© approuvГ© pour un usage mГ©dical aux Г‰tats-Unis en 1998. Les personnes ayant des antГ©cГ©dents de psychose ne doivent pas utiliser ce mГ©dicament sans d'abord consulter un mГ©decin. Jusqu'Г prГ©sent, cependant, les essais cliniques sur le modafinil n'ont pas dГ©montrГ© de maniГЁre concluante son efficacitГ© Г court ou Г long terme. Les symptГґmes d'une somnolence diurne excessive comprennent l'endormissement Г©veillГ©, le sommeil prolongГ© pendant la journГ©e, le manque de sommeil et une mauvaise efficacitГ© du sommeil. Il est disponible en tant que mГ©dicament gГ©nГ©rique. Le modafinil a Г©tГ© introduit dans les annГ©es 1960 par Thierry Palmieri et a subi de nombreux changements au fil du temps dans la structure chimique de la substance. Modiodal Modafinil Il peut agir comme un facilitateur de la production naturelle de dopamine par l'esprit en redirigeant le flux neuronal de dopamine qui se produit lorsque la personne est Г©veillГ©e. Il a Г©tГ© rГ©vГ©lГ© que la combinaison spГ©cifique de modafinil et d'inhibiteur de l'acГ©tylcholinestГ©rase, la rivastigmine, agit de maniГЁre synergique pour produire un effet plus fort sur l'Г©veil. En 1992, des chercheurs de l'UniversitГ© de Lille en France ont lancГ© une Г©tude croisГ©e en double aveugle, contrГґlГ©e par placebo, dans laquelle la moitiГ© des sujets recevaient une dose unique de 600 mg de modafinil le matin et l'autre moitiГ© recevait un placebo (Bottcher et al . La posologie des gГ©lules peut devoir ГЄtre ajustГ©e pour les enfants ou les adolescents. Le modafinil est un antagoniste des rГ©cepteurs alpha 1-adrГ©nergiques et inhibe Г©galement la recapture de la sГ©rotonine. On estime qu'entre 1 et 5 % de la population souffre de ce type de trouble du sommeil. Bien que sa chimie semble logique, le mГ©canisme d'action exact du modafinil n'est pas clair. Le modafinil, lors de la liaison, rГ©duit la recapture neuronale de la dopamine, empГЄchant les niveaux du neurotransmetteur dans la fente synaptique de revenir Г la ligne de base. Le modafinil peut induire des sentiments d'euphorie et des sensations d'Г©nergie. Cependant, cela ne semble pas aider avec le temps qu'il faut pour s'endormir, la qualitГ© du sommeil ou le besoin de sommeil. Il est Г©galement disponible dans le cadre d'un PPP.
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