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06-21-2023, 02:33 AM
(This post was last modified: 06-21-2023, 02:33 AM by Le Modafinil.)
L'action principale du modafinil est en tant que stimulant. Il n'est pas recommandГ© de l'utiliser dans les quatre heures prГ©cГ©dant le coucher, car il peut provoquer de l'insomnie. Il se lie au rГ©cepteur dopaminergique D1 dans les lobes frontal et cingulaire du cortex cГ©rГ©bral. Le modafinil peut amГ©liorer la vigilance gГ©nГ©rale et la concentration en modifiant le rythme d'endormissement. Le modafinil stimule le cerveau et le systГЁme nerveux central en augmentant la libГ©ration du neurotransmetteur noradrГ©naline. L'ampleur de l'effet pharmacocinГ©tique du modafinil 200 mg Г©tait statistiquement significative par rapport au placebo sur la base de l'intervalle de confiance Г 90 %. Semblable Г la cafГ©ine, qui augmente la vigilance, le modafinil augmente la vigilance sans produire d'effet stimulant. Son mГ©canisme d'action peut ГЄtre similaire Г celui de l'amphГ©tamine. Le modafinil n'est pas connu pour crГ©er une dГ©pendance. Le modafinil a Г©tГ© dГ©veloppГ© pour traiter la narcolepsie, mais depuis lors, il est devenu un complГ©ment populaire et lГ©galement disponible pour le grand public. Chaque entreprise a des spГ©cifications lГ©gГЁrement diffГ©rentes pour le mГ©dicament. Les effets indГ©sirables courants comprennent les maux de tГЄte, les troubles du sommeil, les nausГ©es et les Г©tourdissements. Le modafinil est gГ©nГ©ralement bien tolГ©rГ©. Les effets secondaires graves peuvent inclure des rГ©actions allergiques, telles que l'anaphylaxie et le syndrome de Stevens-Johnson, et des hallucinations chez les personnes ayant des antГ©cГ©dents de psychose. Le modafinil est disponible en tant que mГ©dicament gГ©nГ©rique aux Г‰tats-Unis et au Canada ; cependant, le coГ»t est plus Г©levГ© que celui de la version de marque. modafinil europe Dans le SNC, le modafinil augmente l'Г©veil en mГ©diant la libГ©ration de noradrГ©naline. Les mГ©canismes par lesquels le modafinil agit pour augmenter l'Г©veil ne sont pas connus. On pense Г©galement que le modafinil aide Г rГ©duire le besoin habituel de sommeil, ce qui peut aider davantage les personnes Г faire face Г une maladie perturbatrice telle que la narcolepsie. Le modafinil ne doit ГЄtre pris que lorsqu'une personne doit rester Г©veillГ©e. La pharmacologie du mГ©dicament est spГ©cifique : le modafinil agit sur une partie du cerveau impliquГ©e dans la capacitГ© Г dormir. Le modafinil peut ГЄtre pris avec ou sans nourriture. Le modafinil inhibe la recapture de la sГ©rotonine, de la dopamine et de la noradrГ©naline, qui sont libГ©rГ©es pendant le sommeil. La mesure dans laquelle il le fait dГ©pend de la dose. Le modafinil augmente la libГ©ration de noradrГ©naline et de dopamine dans certaines rГ©gions du cerveau. Le modafinil est gГ©nГ©ralement sans danger lorsqu'il est utilisГ© aux doses recommandГ©es, bien que certains effets secondaires puissent survenir. Les patients dГ©clarent se sentir alertes, attentifs, concentrГ©s et Г©nergiques dans les 30 minutes suivant la prise de modafinil. Le modafinil a la mГЄme demi-vie que les amphГ©tamines, a un effet durable (idГ©alement plusieurs heures) et n'est pas mГ©tabolisГ© dans le foie.
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L'administration du mГ©dicament doit commencer 15 Г 30 minutes avant l'induction du sommeil souhaitГ©e et ne doit pas commencer si ce n'est au moins 40 Г 60 minutes avant l'heure d'endormissement prГ©vue. Il rГ©duit le temps nГ©cessaire pour s'endormir. Environ 100 mg Г 300 mg de Modafinil peuvent ГЄtre pris avant le coucher pour affecter le cerveau au milieu de la nuit lorsque vous ГЄtes susceptible de ressentir certains des effets secondaires les plus dangereux de l'utilisation de Modafinil sans surveillance mГ©dicale. Le modafinil a Г©galement Г©tГ© signalГ© comme un traitement potentiel de l'apnГ©e obstructive du sommeil. Modafinil est disponible en deux dosages diffГ©rents, 200 mg et 400 mg. п»їLe modafinil sur ordonnance est une substance contrГґlГ©e et ne doit ГЄtre administrГ© que sous la supervision d'un mГ©decin. Il peut Г©galement aggraver la progression d'autres affections telles que le diabГЁte, les maladies cardiaques et l'hГ©patite C. En 2013, Provigil a gГ©nГ©rГ© des revenus d'environ 1,9 milliard de dollars pour Sun Pharma. Le modafinil est Г©galement recommandГ© comme traitement d'appoint pour les personnes qui n'ont pas rГ©pondu Г l'utilisation d'une thГ©rapie comportementale ou de mГ©dicaments stimulants. Le N-desmГ©thyl modafinil est formГ© par le cytochrome P450. Il est Г©galement utilisГ© hors AMM comme prГ©tendu activateur cognitif pour amГ©liorer l'Г©veil dans les Г©tudes animales et humaines. La plupart des effets secondaires disparaissent aprГЁs l'arrГЄt du mГ©dicament. La dose initiale recommandГ©e de modafinil est de 200 Г 300 mg par jour, avec possibilitГ© de titration jusqu'Г 600 mg par jour. modafinil europe Provigil/modafinil a Г©tГ© approuvГ© pour un usage mГ©dical aux Г‰tats-Unis en 1998 par la Food and Drug Administration. Le mГ©dicament est disponible Г l'achat sans ordonnance, mais il est gГ©nГ©ralement prescrit avec un mГ©dicament induisant le sommeil approuvГ© par la FDA, tel que le zolpidem, un mГ©dicament contre l'insomnie. Il est utilisГ© pour traiter la somnolence diurne excessive associГ©e Г la narcolepsie. Bien que l'effet soit principalement sur le systГЁme d'excitation, le modafinil semble Г©galement affecter la fonction exГ©cutive. Le modafinil est un inhibiteur de l'acГ©tylcholinestГ©rase, comme le donГ©pГ©zil et la rivastigmine. Il peut ГЄtre pris le matin ou, moins frГ©quemment, en fin d'aprГЁs-midi. Cependant, des recherches plus rГ©centes ne corroborent pas cette conclusion. Le sirop est disponible en dose de 50 mg/5 ml. L'ingrГ©dient actif du modafinil est le 2-[(diphГ©nylmГ©thyl)sulfinyl]-acГ©tamide, Г©galement connu sous le nom de 2-diphГ©nylsulfinyl acГ©tamide, et souvent abrГ©gГ© en Dipsan. Le Modafinil a Г©tГ© dГ©veloppГ© par le neurologue Michel Jouvet et les Laboratoires Lafon. fabriquent du modafinil au Japon.
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