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#6
Un comité consultatif de la FDA en 2013 a trouvé des preuves à l'appui de son utilisation comme améliorateur de performance diurne, avec la mise en garde qu'il pourrait ne pas être efficace chez les personnes souffrant de troubles du sommeil. Dans le corps, le modafinil est décomposé par le métabolisme hépatique. Les deux groupes avaient un âge, un poids et un sexe très similaires. Le modafinil est généralement bien toléré, avec des effets secondaires possibles, notamment des maux de tête, des troubles du sommeil et des nausées. Il n'est pas clair si l'utilisation pendant la grossesse est sans danger. Le modafinil a été qualifié d'"agoniste de la dopamine", car il semble être un agoniste dans le cortex préfrontal et l'hypothalamus, et plutôt un antagoniste ailleurs dans le cerveau. Ce site fait partie des récepteurs GABA. Développé à l'origine par le neuroscientifique français Michel Jouvet et les laboratoires Lafon, le modafinil est prescrit en France depuis 1994 et a été approuvé pour un usage médical aux États-Unis en 1998. Il est disponible sur ordonnance aux États-Unis. Dans la narcolepsie, un trouble actuellement incurable avec les médicaments actuels, des médicaments comme le Modafinil peuvent aider à soulager les symptômes. Le modafinil n'est pas recommandé pendant la grossesse. Il est également utilisé dans le traitement de la somnolence excessive chez les personnes atteintes du syndrome d'apnée obstructive du sommeil. modafinil en ligne Le médicament agit en augmentant la libération de dopamine dans le cortex cérébral, une action qui est diminuée par la stimulation sensorielle. Des effets cognitifs ont été observés chez deux personnes privées de sommeil ayant reçu une seule dose de 200 mg de modafinil. Ce métabolisme impliquerait les produits du gène CYP2D6 (métaboliseurs) ou du gène CYP2C19 (métaboliseurs lents). Ces effets créent un état neurochimique qui améliore l'éveil. Certains trouvent que cela les aide en fait à s'endormir plus rapidement. Le modafinil est légèrement plus puissant que l'amphétamine et est environ trois fois plus puissant que le méthylphénidate moins connu. Le modafinil est disponible en doses de 200 mg, 400 mg et 600 mg. L'effet secondaire le plus courant est une somnolence modérée. Modafinil n'est pas approuvé pour toutes les utilisations. Cela signifie qu'il augmente l'activité des monoamines dans le cerveau en inhibant la recapture des neurotransmetteurs, ce qui entraîne une augmentation de l'activité des neurones et améliore la vigilance. L'alpha-chloréthyl est formulé en comprimés de 100mg/100mg et 160mg/100mg. Bien qu'il existe certaines preuves de son efficacité en tant qu'amplificateur cognitif, il n'y a aucune preuve solide que le modafinil améliore le fonctionnement cognitif. Cette forme peut être administrée par voie sous-cutanée. C'est un agoniste sélectif des récepteurs adrénergiques alpha-1A.

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Votre médecin peut recommander au patient de commencer une faible dose de modafinil et d'augmenter la dose recommandée. Il peut également affecter le métabolisme de la dopamine et d'autres neurotransmetteurs, mais les preuves en sont limitées aux études sur les animaux. L'arrêt est recommandé dès les premiers signes d'éruption cutanée ou de réactions similaires. Il existe des preuves provisoires que le modafinil peut réduire le risque de problèmes cardiovasculaires et réduire le risque de vertiges associés à l'augmentation des taux de calcium dans le sang. La recherche actuelle suggère que le Modafinil est un stimulateur sélectif de la libération de DA, ce qui signifie qu'il peut avoir des effets positifs sur ceux qui ont des problèmes d'attention comme le TDA ou le TDAH. Le modafinil agit en inhibant le transporteur de la dopamine, augmentant ainsi la quantité de neurotransmetteur disponible pour la libération. Les personnes ayant des antécédents familiaux de problèmes cardiaques ou d'hypertension artérielle courent un risque accru de tels problèmes lors de l'utilisation de Modafinil. Il est disponible en tant que médicament générique. Lorsque le modafinil est administré à des rongeurs, il produit des changements dans les niveaux de dopamine qui se reflètent dans un comportement éveillé inapproprié. Cela signifie qu'il imite la façon dont le cerveau traite les messagers chimiques naturels dans le corps appelés neurotransmetteurs, qui sont responsables du contrôle des humeurs du corps, de l'activité mentale, de l'appétit, du sommeil et de nombreuses autres fonctions. Le modafinil est prescrit pour le traitement des troubles du sommeil tels que la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. modafinil en ligne Le modafinil est prescrit pour traiter la narcolepsie. Il semble également être un antagoniste des récepteurs noradrénergiques et histaminergiques, servant éventuellement d'antagoniste du récepteur alpha1. Dans une déclaration du fabricant sur l'utilisation du médicament comme activateur cognitif, il est mentionné que deux études croisées en double aveugle, contrôlées par placebo, pour l'amélioration cognitive chez l'homme suggèrent que le modafinil ne semble pas améliorer l'attention ou la mémoire de travail chez les individus en bonne santé. Les effets secondaires du modafinil peuvent également inclure des troubles du sommeil, des nausées, des maux d'estomac ou des étourdissements. Le modafinil fait partie d'une classe de médicaments appelés sédatifs-hypnotiques/hypnotiques, qui bloquent le neurotransmetteur adénosine, en particulier dans le cerveau, afin d'aider à contrôler la quantité de somnolence/fatigue. Les effets biochimiques du modafinil sont largement dus à l'inhibition de la recapture de la dopamine et de la noradrénaline. La FDA déclare que les effets secondaires du Modafinil incluent « somnolence, étourdissements, maux de tête, nausées, vomissements, douleurs abdominales, bouche sèche, agitation, tension musculaire, hallucinations, hostilité, lassitude, nervosité, anxiété, perte de libido, difficultés respiratoires, diurèse (sauf chez les patients dont la fonction rénale est altérée) et les troubles du sommeil. Le modafinil est une phénéthylamine. Les patients doivent noter l'heure exacte à laquelle la dose est prise, car cela permet de déterminer dans quelle mesure le médicament est efficace et dans quelle mesure la dose est nécessaire. Il est pris avec de la nourriture pour prévenir les nausées.

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#7
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#8
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инфоинфоинфоинфоинфоинфоинфоинфоинфоинфоинфоинфоинфоtuchkasинфоинфо
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#9
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#10
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