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Le modafinil offre une alternative au mГ©dicament dГ©livrГ© uniquement sur ordonnance, le mГ©thylphГ©nidate (Ritalin). Cela amГ©liore la vigilance, l'Г©veil et la vigilance, et diminue Г©galement la fatigue. La dose recommandГ©e de Modafinil pour les travailleurs postГ©s est de 150 Г  300 mg par jour. Les patients qui ont pris du modafinil ont continuГ© Г  se sentir plus alertes pendant la journГ©e que ceux sous placebo. Le modafinil est gГ©nГ©ralement fourni sous forme de comprimГ© blanc Г  blanc cassГ©, Г  dГ©sintГ©gration orale. Il n'est pas recommandГ© chez les personnes souffrant d'arythmie, d'hypertension artГ©rielle importante ou d'hypertrophie ventriculaire gauche. La FDA avertit que les personnes qui consomment rГ©guliГЁrement trois boissons ou plus contenant de la cafГ©ine devraient commencer par une dose plus faible et augmenter lentement au fur et Г  mesure qu'elles s'habituent aux effets stimulants de la cafГ©ine. Cet effet est supГ©rieur Г  l'effet des amphГ©tamines. L'ingrГ©dient actif du modafinil est le citrate de modafinil. Certains mГ©dicaments, y compris Modafinil, peuvent provoquer ou aggraver ces affections. Il agit comme un stimulant du systГЁme nerveux central en augmentant l'activitГ© de la dopamine et en affectant le cycle В«sommeil-Г©veilВ» du cerveau. Dans les Г©tudes animales, il a Г©tГ© dГ©montrГ© que le Modafinil a des effets similaires Г  ceux du mГ©thylphГ©nidate, un autre mГ©dicament connu pour augmenter l'Г©veil, mais avec beaucoup moins de risque de dГ©pendance et d'abus. Les effets secondaires rares et graves comprennent des rГ©actions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antГ©cГ©dents de psychose. Une version Г  libГ©ration contrГґlГ©e a Г©tГ© utilisГ©e pour traiter l'alcoolisme. nootropique pharmacie Le modafinil est gГ©nГ©ralement disponible sous forme de comprimГ©s et se prend par voie orale. Le modafinil manque Г©galement de nombreux potentiels de dГ©pendance et d'abus associГ©s Г  d'autres stimulants tels que la cocaГЇne et l'amphГ©tamine. La stimulation de ces neurones peut provoquer plusieurs types d'effets sur les nerfs, les muscles et les glandes. Le modafinil a gГ©nГ©ralement un meilleur profil d'innocuitГ© que la cocaГЇne, bien qu'il ait moins d'effets euphorisants. Les National Institutes of Health des Г‰tats-Unis notent que, bien que le Modafinil ait Г©tГ© Г©tudiГ© comme un Г©ventuel activateur cognitif, des recherches supplГ©mentaires sont nГ©cessaires. La dose quotidienne maximale est de 400 mg chez l'adulte. D'autres mГ©dicaments actifs sur le SNC, y compris les antidГ©presseurs trazodone, bupropion, mirtazapine, SNRI et IMAO, doivent Г©galement ГЄtre Г©vitГ©s. Les comprimГ©s Г  libГ©ration prolongГ©e (Modalert) contiennent les mГЄmes ingrГ©dients que les comprimГ©s Г  libГ©ration immГ©diate, mais ils ont un enrobage Г  libГ©ration retardГ©e qui agit sur une pГ©riode de plusieurs heures. Les effets secondaires rares et graves peuvent inclure des rГ©actions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antГ©cГ©dents de psychose. Le modafinil est gГ©nГ©ralement pris au besoin. Il a Г©tГ© dГ©montrГ© que le modafinil agissait de la mГЄme maniГЁre chez les rongeurs de laboratoire et d'autres espГЁces, y compris les humains, pour prГ©venir В«l'inertie du sommeilВ», une condition dans laquelle les animaux deviennent fatiguГ©s et dГ©sorientГ©s aprГЁs s'ГЄtre rГ©veillГ©s d'une sieste ou d'un sommeil.

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Le modafinil peut agir sur divers neurotransmetteurs du cerveau et du système nerveux central. Le modafinil est un stimulant du système nerveux central. La liaison au site de liaison du modafinil va stimuler le récepteur, provoquant une augmentation de l'action du neurotransmetteur GABA, conduisant à un effet inhibiteur du sommeil plus fort, et donc moins de somnolence diurne. Le modafinil est un médicament utilisé depuis les années 1970, principalement dans le traitement de la narcolepsie, et qui est actuellement à l'étude à d'autres fins. Il est généralement pris 1 à 2 heures avant le coucher, bien que les effets puissent prendre jusqu'à 6 heures pour se développer. Il doit être utilisé avec parcimonie. Les concentrations plasmatiques maximales surviennent environ 2 heures après l'administration. Dans l'étude, neuf travailleurs postés souffrant de troubles du sommeil liés au travail posté ont reçu du Modafinil pendant quatre semaines. Le modafinil est également utilisé pour traiter la narcolepsie, qui est une maladie extrêmement débilitante caractérisée par des cycles de sommeil anormaux qui amènent les patients à s'endormir à des moments inappropriés de la journée. Le modafinil sous sa forme générique est un mélange racémique qui combine les énantiomères du modafinil et est vendu comme énantiomère d'origine ou supplémentaire. Il peut également être utilisé pour améliorer l'éveil chez les personnes qui souhaitent améliorer leur qualité de vie ou participer à des activités professionnelles et scolaires. Des études sur le médicament suggèrent qu'il est efficace dans le traitement des troubles du sommeil liés au travail posté. En raison de sa ressemblance avec la dopamine dans sa structure chimique, le modafinil se lie aux récepteurs de la dopamine, qui ont un effet calmant sur le cerveau, bien que ses effets ne soient pas identiques à ceux de la dopamine naturelle. Il est pris par la bouche. nootropique pharmacie La posologie variera en fonction de l'état de l'utilisateur et des autres médicaments qu'il prend. Le modafinil est utilisé pour améliorer la concentration, la motivation et la vigilance chez les personnes dont le sommeil est de mauvaise qualité. La dose adulte recommandée de modafinil est de 100 à 200 mg trois fois par jour, selon l'indication et d'autres facteurs. Dans une étude, le modafinil s'est avéré stable jusqu'à quatre ans s'il est conservé à une température ne dépassant pas 25°C. Le modafinil est principalement utilisé pour traiter la somnolence diurne dans la narcolepsie, un type d'hypersomnie idiopathique, la forme la plus courante de la maladie. Il est disponible sous les noms Citalopram Modafinil (Modalert), Citadine 100mg Modafinil (Citidin), Modafinil-Hcl (Provigil), Modafinil (Provigil-Hcl) et Modafinil (Aricept). Le modafinil est un médicament stimulant sur ordonnance utilisé pour aider les gens à rester éveillés. Il provoque une augmentation des niveaux extracellulaires d'adénosine et d'adénosine triphosphate (ATP) dans le cerveau en inhibant le cytochrome-P450 (CYP) 2D6, ce qui entraîne une augmentation de l'adénosine. Aucun ajustement posologique n'est recommandé chez les patients pédiatriques. La dose maximale habituelle est de 400 mg par jour.

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