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(This post was last modified: 01-03-2023, 08:42 AM by Modafinil 200 .)
Le modafinil a une courte demi-vie plasmatique de 30 Г 90 minutes et est mГ©tabolisГ© par la bГЄta-oxydation des acides gras. Provigil (modafinil, sous le nom de marque Provigil entre autres) est le premier membre d'une classe de mГ©dicaments connus sous le nom d'agents favorisant l'Г©veil, plus communГ©ment appelГ©s alternatives au modafinil. Il amГ©liore Г©galement la vigilance des personnes souffrant de troubles du sommeil liГ©s au travail postГ©. De nombreux effets secondaires ont Г©tГ© rapportГ©s avec l'utilisation du modafinil, avec moins d'effets secondaires ressentis Г des doses plus Г©levГ©es. Il est recommandГ© de le prendre en association avec des changements de mode de vie. Le modafinil est un stimulant faible et ne provoque gГ©nГ©ralement pas d'augmentation du rythme cardiaque ou de la pression artГ©rielle. AprГЁs les Г©valuations de base et de quatre semaines, les participants ont Г©tГ© traitГ©s avec un placebo ou du modafinil pendant quatre semaines.
Provigil En Maroc Ils sont Г©galement gГ©nГ©ralement bien tolГ©rГ©s. Parce qu'il s'agit d'un stimulant du systГЁme nerveux central, le modafinil peut crГ©er ou aggraver des symptГґmes psychotiques tels que la paranoГЇa. Il est Г©galement connu sous le nom d'Armodafinil ou d'Aimafinil. D'autres effets secondaires incluent des nausГ©es, des maux de tГЄte, des troubles du sommeil et une diminution de la libido. L'American Urological Association a rГ©cemment annoncГ© qu'elle allait soutenir une Г©tude sur les effets du modafinil sur la somnolence diurne due Г l'apnГ©e obstructive du sommeil. п»їLe modafinil a Г©tГ© dГ©veloppГ© dans les annГ©es 1970 par les laboratoires Michel Jouvet et Lafon et a Г©tГ© approuvГ© pour un usage mГ©dical aux Г‰tats-Unis en 1998. Dans un essai clinique contrГґlГ© qui comprenait deux groupes de travailleurs postГ©s, ceux qui prenaient du modafinil n'ont pas dГ©montrГ© un taux plus Г©levГ© d'Г©vГ©nements indГ©sirables ou de somnolence, et ont pu continuer Г effectuer un travail postГ©, tandis que ceux qui recevaient un placebo n'Г©taient pas en mesure de continuer le travail postГ©. Il est gГ©nГ©ralement pris deux fois par jour. Les effets secondaires courants comprennent les nausГ©es, les troubles du sommeil et les maux de tГЄte. La plupart des Г©tudes sur le modafinil ont utilisГ© des doses de 200 mg et 400 mg.
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Le modafinil est un stimulant à action centrale. Le modafinil n'a pas été conçu pour être utilisé comme activateur cognitif, mais plutôt comme traitement des troubles du sommeil; on pense qu'il agit en augmentant l'éveil, en produisant une augmentation de l'énergie cognitive et émotionnelle et en réduisant la fatigue. Cephalon a rapporté que la dose de modafinil que Cephalon recommande actuellement est de 150 mg pris jusqu'à trois fois par jour. Le modafinil n'est pas approuvé pour le traitement du trouble d'hyperactivité avec déficit de l'attention (TDAH). Il peut être pris en association avec d'autres médicaments pour traiter d'autres affections.
Provigil En Maroc Pris par voie orale, le modafinil peut ГЄtre pris une ou plusieurs fois par jour, avant de dormir ou avant une activitГ© spГ©cifique, comme un examen ou un entretien d'embauche. C'est aussi un inhibiteur de la recapture de l'adГ©nosine, inhibant l'enzyme responsable de la dГ©gradation de l'adГ©nosine, qui inhibe l'Г©veil et est un facteur de troubles du sommeil. Une grande partie de la recherche sur l'utilisation du modafinil est centrГ©e sur son efficacitГ© pour l'apnГ©e du sommeil. Les rГ©cepteurs D3 sont stimulГ©s par les rГ©cepteurs D2, et non par la dopamine, expliquant pourquoi le modafinil peut avoir des effets secondaires nГ©gatifs tels que l'insomnie. La quantitГ© de mГ©dicament utilisГ©e peut devoir ГЄtre ajustГ©e chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques. Chaque comprimГ© contient 100 mg de modafinil et chaque capsule contient 200 mg de modafinil. Le modafinil est structurellement similaire Г la cafГ©ine, et agit Г©galement sur un rГ©cepteur NMDA, et similaire aux composants actifs de la plante de coca. Le modafinil est utilisГ© Г des doses mГ©dicales de 0,25 Г 1,2 mg trois fois par jour et a Г©tГ© commercialisГ© sous le nom de Provigil aux Г‰tats-Unis pour le traitement de la somnolence diurne excessive, y compris le trouble du travail postГ©. C'est Г©galement une forme optiquement pure dextrogyre de la cafГ©ine, ce qui la distingue pharmacologiquement de la cafГ©ine. Bien qu'il ne s'agisse pas d'un mГ©dicament de l'annexe II ou III, le modafinil est approuvГ© pour un usage mГ©dical uniquement, car il n'est pas approuvГ© pour un usage rГ©crГ©atif ou disponible sur Internet. Dix milligrammes est la dose initiale recommandГ©e.
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Des Г©tudes pharmacocinГ©tiques ont montrГ© qu'aprГЁs ingestion, la concentration plasmatique du modafinil est atteinte en 1,5 Г 4 heures, le pic plasmatique est atteint en 3 heures et la demi-vie du modafinil est comprise entre 11 et 14 heures. On pense qu'il agit en stimulant plusieurs rГ©cepteurs dans le cerveau. Une dose standard de 200 mg, prise pas plus d'une fois par jour, est suffisante pour la plupart des individus. Cette mГЄme annГ©e, il a Г©tГ© autorisГ© au Canada. Le mГ©dicament est gГ©nГ©ralement administrГ© par voie orale.
Provigil En Maroc Cela peut rГ©duire la qualitГ© du sommeil de certaines personnes. C'est un stimulant du systГЁme nerveux central (SNC) qui agit comme un antagoniste des rГ©cepteurs de l'adГ©nosine au niveau du sous-type DA-2. Le modafinil agit en augmentant l'activitГ© des neurotransmetteurs qui aident le cerveau humain Г contrГґler la vigilance ou l'attention. Le modafinil, cependant, n'est pas tout Г fait un pur bloqueur de DAT. Ceux qui prennent du modafinil ont signalГ© une amГ©lioration gГ©nГ©rale de la mГ©moire, de la concentration, de la concentration, de l'attention et de l'Г©nergie, et certains ont Г©galement signalГ© une augmentation des sentiments de motivation et de crГ©ativitГ©. La pharmacologie du modafinil est similaire Г celle des amphГ©tamines. La lГ©vodopa/amphГ©tamine provoque l'activation des neurones dopaminergiques (vert), qui augmentent les niveaux de dopamine (jaune) et provoquent l'Г©veil. En tant que stimulant, Modafinil agit en augmentant les niveaux de neurotransmetteurs dans le cerveau. Le modafinil est fabriquГ© par Sun Pharmaceutical, bien que le seul traitement de marque soit maintenant vendu par Sun sous le nom de Provigil. Bien que cela ne fonctionne pas pour tout le monde, environ 40 % des gens y rГ©pondent bien. On suppose que le modafinil fonctionne en augmentant le nombre de DAT dans les synapses, et en augmentant ainsi la concentration synaptique de dopamine.
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