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Le modafinil est disponible sous trois formes : citrate, citrate et citrate citrate. Les deux Г©nantiomГЁres principaux sont le R-modafinil, une image miroir de la D-amphГ©tamine, et l'Г©nantiomГЁre S modafinil est Г©galement une image miroir du R-modafinil. Cela rend une personne moins fatiguГ©e pendant le sommeil, l'aidant ainsi Г  obtenir un sommeil plus rГ©parateur. Il ne modifie pas le besoin de sommeil. De plus, il est disponible sous forme de comprimГ© sublingual (sous la langue) pour les situations d'urgence. Le modafinil inhibe l'activitГ© enzymatique CYP2C19, ce qui signifie qu'il ne doit pas ГЄtre administrГ© avec le clopidogrel. L'isomГ©rie est importante car on sait que l'isomГЁre dextro a une plus grande affinitГ© pour le rГ©cepteur 5-HT2C. Cependant, lorsque les chercheurs ont analysГ© les donnГ©es de sommeil sur la polysomnographie, la diffГ©rence entre les groupes n'Г©tait pas significative. Le modafinil agit en stimulant certains rГ©cepteurs dans le cerveau, empГЄchant les signaux qui conduisent au sommeil d'atteindre le cerveau. Le modafinil rГ©duit la transmission des catГ©cholamines, y compris l'activation de l'amygdale, chez l'homme. Le mГ©dicament augmente l'Г©veil et amГ©liore l'humeur et le fonctionnement cognitif chez les personnes souffrant d'Г©pisodes de sommeil prolongГ©s dus Г  des troubles tels que la narcolepsie et les troubles du travail postГ©. Stimulant Intellectuel Sans Ordonnance Il augmente la libГ©ration de dopamine, un neurotransmetteur clГ© impliquГ© dans le systГЁme de rГ©compense du cerveau et est impliquГ© dans la libГ©ration cГ©rГ©brale de noradrГ©naline ou de noradrГ©naline. Le modafinil agit en augmentant la libГ©ration de dopamine dans le cerveau, ce qui augmente ensuite les niveaux du neurotransmetteur Г©pinГ©phrine (adrГ©naline). Il se lie au transporteur de la dopamine avec une affinitГ© beaucoup plus Г©levГ©e qu'un certain nombre d'autres stimulants, Г  la fois in vitro et in vivo. Le modafinil n'est pas largement disponible en tant que mГ©dicament sur ordonnance dans aucun autre pays. Le modafinil est pris au besoin tout au long de la journГ©e, plutГґt que comme mГ©dicament une fois par jour. L'indinavir, un inhibiteur de la protГ©ase du VIH, inhibe faiblement l'activitГ© du CYP1A2 d'environ 30 % Г  40 %. La dopamine est une substance chimique du cerveau qui joue un rГґle dans le mouvement, la motivation et la rГ©compense. Le modafinil est un analogue du neurotransmetteur dopamine, qui est un neurotransmetteur naturellement prГ©sent dans le cerveau. L'utilisation de Modafinil et de naltrexone peut augmenter le risque de vertiges ou d'hallucinations. Au Canada, le modafinil SR est Г©galement disponible sous forme de formulation de trois heures pour un Г©quivalent de quatre doses par jour. Il agit en augmentant l'activitГ© de certains types de cellules nerveuses (appelГ©es neurones) et en rГ©gulant l'activitГ© d'un certain type de cellules cГ©rГ©brales (appelГ©es cellules gliales). Si une infection survient, le mГ©decin peut exiger un changement temporaire de traitement mГ©dicamenteux. Le modafinil est disponible sous forme de comprimГ© et se prend environ 30 minutes avant le coucher. Le modafinil n'est plus approuvГ© par la Food and Drug Administration (FDA) des Г‰tats-Unis pour le travail postГ©, l'agence recommandant Г  la place des options de traitement alternatives.

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La moitiГ© du modafinil absorbГ© est mГ©tabolisГ©e dans le foie. Cependant, si la mГЁre choisit d'interrompre l'allaitement, elle doit ГЄtre informГ©e de le faire lorsqu'elle ne prend pas de modafinil, ou de passer Г  un autre mГ©dicament, ou d'arrГЄter complГЁtement l'allaitement. Le modafinil est un mГ©dicament stimulant largement utilisГ© pour traiter la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e du sommeil, et il augmente l'Г©veil, la concentration, la vigilance, l'appГ©tit et la libido. Modafinil est un mГ©lange racГ©mique et a une formule empirique de C12H11NOS. Au moment de son approbation en 1994 en France, le Modafinil Г©tait dГ©jГ  utilisГ©, de maniГЁre ponctuelle, dans de multiples essais humains. Les autres marques incluent Adrafinil SR, Armodafinil et Armodafinil intraveineux. Il est important de noter qu'il n'est pas clair si l'utilisation du modafinil pendant la grossesse est sans danger. Modafinil est une marque dГ©posГ©e de Sunovion Pharmaceuticals, Inc. Le modafinil imite les effets de la cafГ©ine, mais a un effet plus doux que la cafГ©ine. Les directives de traitement pour la somnolence diurne excessive et les troubles du sommeil liГ©s au travail postГ© recommandent le modafinil comme traitement de premiГЁre ligne pour la somnolence diurne excessive. Stimulant Intellectuel Sans Ordonnance Le modafinil est Г©galement disponible en comprimГ©s Г  libГ©ration prolongГ©e de 100 mg et 200 mg qui peuvent ГЄtre pris Г  tout moment de la journГ©e. Il a Г©tГ© dГ©montrГ© en laboratoire qu'il augmente les niveaux de divers neurotransmetteurs, notamment l'acГ©tylcholine, la dopamine et la sГ©rotonine, ce qui peut expliquer son succГЁs dans le traitement des troubles du sommeil. Le modafinil amГ©liore l'attention, augmente la concentration, amГ©liore les fonctions cognitives, favorise l'Г©veil, agit comme un agent libГ©rant de la norГ©pinГ©phrine et augmente la fente synaptique (Г©cart des cellules cГ©rГ©brales). Le modafinil est l'ingrГ©dient actif du mГ©dicament et est fabriquГ© par Sun Pharmaceutical Industries, Ltd. On pense que l'Г©nantiomГЁre (-) est responsable des effets nootropiques du mГ©dicament. La posologie rГ©guliГЁre est de 100 Г  200 mg; une utilisation prolongГ©e (plus de 14 jours) peut entraГ®ner une prise de poids, des troubles du sommeil, de la nervositГ©, des Г©tourdissements et de la somnolence. Une autre marque moins courante de modafinil, Aurum, est disponible en comprimГ©s de 5 mg, 10 mg et 50 mg. Cependant, la Food and Drug Administration (FDA) des Г‰tats-Unis a niГ© cette classification. Le modafinil est capable d'induire des effets noradrГ©nergiques deux fois plus longtemps que les amphГ©tamines. Le brevet de Provigil a Г©tГ© attribuГ© Г  Sunovion au milieu des annГ©es 1980. Il s'agit d'une prodrogue oralement active du d-modafinil qui se transforme rapidement en neurostimulant actif d-modafinil lorsqu'il pГ©nГЁtre dans le cerveau. L'amГ©lioration de ce mГ©canisme peut ГЄtre la raison de l'utilisation rГ©ussie du modafinil dans le travail postГ©. Le surdosage de Modafinil n'est pas recommandГ©.

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