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Modafinil est chimiquement décrit comme benzimidazole-2-thione, et sa formule moléculaire est C14H15N3S. Le modafinil est disponible en doses de 150 mg, 200 mg et 400 mg. Cet effet dure 6 à 7 heures. Son action se fait via le récepteur dopaminergique D1. La forme phosphorylée semble traverser la barrière hémato-encéphalique. Cette voie joue un rôle important dans la réduction de la somnolence et peut également activer les voies de l'orexine. La dose maximale recommandée est de 400 mg par jour. Par conséquent, l'EMA n'a aucune obligation d'approuver le modafinil pour un usage médical. Environ 100 mg à 300 mg de Modafinil peuvent être pris avant le coucher pour affecter le cerveau au milieu de la nuit lorsque vous êtes susceptible de ressentir certains des effets secondaires les plus dangereux de l'utilisation de Modafinil sans surveillance médicale. Prendre du modafinil à la même heure chaque jour est important car le prendre trop tard peut ne pas avoir d'effet. modafinil canada Le modafinil affecte le SNC en agissant sur des sites du cerveau qui contrôlent l'éveil et le sommeil. Le composé actif du modafinil, la 2-(diphénylméthyl)hydrazine, est similaire à d'autres médicaments qui ont été utilisés pour traiter les troubles du sommeil, bien que le modafinil n'ait pas les mêmes effets secondaires. Le modafinil et de nombreux autres stimulants sont utilisés pour traiter et prévenir la somnolence et la fatigue dues à la narcolepsie, aux troubles du sommeil liés au travail posté ou à l'apnée obstructive du sommeil. Il a été approuvé aux États-Unis en 1999. C'est un analogue chimique proche de la caféine stimulante et peut affecter le système nerveux central (SNC) de la même manière. Le médecin peut avoir besoin d'ajuster la posologie du médicament chez les personnes atteintes d'une maladie cardiovasculaire préexistante. Modafinil a été commercialisé sous un certain nombre de noms de marque, notamment Provigil, Nuvigil et Armodafinil. Le modafinil se prend par voie orale. Il est hautement métabolisé dans le foie, où il est converti en l'énantiomère R du modafinil (R-Modafinil). Le modafinil est également utilisé par certaines personnes atteintes de TDAH et d'autres troubles psychologiques dans le cadre d'une soi-disant «amélioration cognitive» pour tenter d'améliorer les performances cognitives. Ce groupe a servi de groupe témoin et de groupe placebo, puisqu'il n'a reçu que le véhicule utilisé pour administrer les deux autres groupes.
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