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#8
Il existe cependant relativement peu de donnГ©es soutenant l'utilisation du modafinil pour le TDAH. Les premiers essais sur l'homme ont Г©tГ© menГ©s par Philippe Devillard et Michel Jouvet de l'UniversitГ© de Bordeaux, laurГ©ats du prix Nobel de physiologie et mГ©decine en 1992, et les premiers essais sur l'homme ont Г©tГ© utilisГ©s en 1993 par la sociГ©tГ© europГ©enne Lafon. Le modafinil, vendu entre autres sous le nom de marque Provigil, est un stimulant du systГЁme nerveux central (SNC) utilisГ© pour traiter la somnolence due Г  la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil. Il agit comme un antagoniste des rГ©cepteurs de l'adГ©nosine A2A. Il agit en stimulant la libГ©ration des neurotransmetteurs noradrГ©naline et dopamine, conduisant Г  l'Г©veil. Il a Г©galement Г©tГ© dГ©montrГ© que le modafinil affecte le thalamus, qui est impliquГ© dans la rГ©gulation du sommeil et de l'Г©veil. On pense que le modafinil agit sur les niveaux de dopamine et d'adГ©nosine dans le cerveau. Cependant, le modafinil n'est pas disponible au Royaume-Uni et n'est dГ©livrГ© sur ordonnance que dans la plupart des autres pays. Le mГ©dicament augmente l'Г©veil et, Г  fortes doses, amГ©liore Г©galement la motivation au travail et la mГ©moire Г  court terme. Son utilisation aux Г‰tats-Unis n'a Г©tГ© approuvГ©e pour aucune indication clinique. Modafinil ou Provigil est une marque dГ©posГ©e du nom de marque du mГ©dicament Provigil fabriquГ© et distribuГ© par Cephalon, Inc. Une dose de 200 Г  400 mg, selon les individus, peut ГЄtre prise en deux prises fractionnГ©es. Il est donc important de prendre ce mГ©dicament Г  un moment oГ№ il est peu probable que le patient ait oubliГ© une dose. Le modafinil est un mГ©dicament destinГ© Г  vous aider Г  fonctionner de maniГЁre trГЁs importante. provigil france Cette forme active a Г©tГ© proposГ©e pour se lier aux rГ©cepteurs dopaminergiques D-2, entraГ®nant une stimulation moins puissante du systГЁme dopaminergique, et stimuler plus efficacement les rГ©cepteurs acГ©tylcholinergiques ou noradrГ©nergiques. Il est absorbГ© par le sang et affecte directement le systГЁme nerveux central (SNC) et affecte la libГ©ration de dopamine, une substance chimique dans le cerveau. Les autres effets secondaires comprennent les nausГ©es, les vomissements, les douleurs abdominales et la diarrhГ©e. Ceux-ci sont essentiels pour moduler les niveaux de sommeil et d'Г©veil. La dose habituelle, prise Г  jeun, est de 100 Г  200 mg. Le modafinil peut ГЄtre pris Г  jeun, ou avec un repas ou une boisson. Cela peut Г©galement provoquer une sensation d'agitation ou d'agitation. La narcolepsie avec cataplexie peut survenir en rГ©ponse Г  certains Г©vГ©nements (par exemple, la lumiГЁre, la dГ©shydratation ou le stress). La plupart de ces problГЁmes ont Г©tГ© jugГ©s comme Г©tant probablement ou certainement liГ©s au mГ©dicament. Si vous prenez l'un de ces mГ©dicaments et que vous prenez Г©galement du modafinil, votre dose de ce mГ©dicament doit ГЄtre diminuГ©e de 50 %. Son code national des mГ©dicaments est 42380 et son nom de marque est Modafinil. Chez un patient dont le rythme veille-sommeil est normal, l'apnГ©e du sommeil peut parfois ГЄtre traitГ©e sans perturber le sommeil. Le modafinil est un mГ©dicament sympathomimГ©tique.

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