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Contrairement Г la plupart des autres stimulants du SNC, il agit via un mГ©canisme d'action diffГ©rent de celui des amphГ©tamines. Il a Г©tГ© brevetГ© en 1976 par Thomas W. Le modafinil est vendu sous forme de comprimГ© Г libГ©ration prolongГ©e. Le modafinil est une poudre cristalline blanche ou blanc cassГ©. Le modafinil est principalement mГ©tabolisГ© dans le foie et les reins. Bien qu'il ait Г©tГ© retirГ© de l'Г©tiquette en tant que prГ©tendu activateur cognitif pour amГ©liorer l'Г©veil, la preuve de son efficacitГ© pour cette utilisation n'est pas concluante, bien que sa contribution possible aux performances scolaires ou Г l'apprentissage ait Г©tГ© Г©tudiГ©e pour cette utilisation. Le modafinil a Г©galement un effet central possible sur l'acide gamma-aminobutyrique (GABA), similaire Г l'effet d'autres benzodiazГ©pines. La posologie du modafinil (modalert) varie. Dans la plupart des situations, le modafinil est commencГ© Г 100 milligrammes et pris jusqu'Г 400 milligrammes pour Г©viter de se sentir "Г©levГ©", mais certains patients peuvent n'avoir besoin de prendre que 100 milligrammes deux fois par jour. Le modafinil est mГ©tabolisГ© par hydrolyse par le systГЁme du cytochrome P450. C'est un inhibiteur actif, sГ©lectif et rГ©versible du transporteur de la dopamine (DA) et du transporteur de la noradrГ©naline (NE). On ne pense pas qu'il provoque une dГ©pendance ou des symptГґmes de sevrage. Le modafinil augmente les niveaux d'Г©veil Г court et Г long terme. nootropique achat Le modafinil a Г©tГ© dГ©crit comme le premier nouveau traitement de l'apnГ©e du sommeil en 20 ans. La limite supГ©rieure recommandГ©e est de 400 mg. Cependant, il a une demi-vie plus longue. Le modafinil a Г©galement Г©tГ© utilisГ© comme traitement sans ordonnance des Г©tats de fatigue causГ©s par des rГ©gimes pauvres en acides gras essentiels et dГ©ficients en sommeil, comme l'anorexie mentale, entraГ®nant la formation d'hypoglycГ©mies. Ceci est soutenu par son affinitГ© pour les rГ©cepteurs dopaminergiques D1, D2, D3 et D4. L'essai comprenait 218 patients qui ne rГ©pondaient pas Г deux Г quatre mois de thГ©rapie comportementale. On pense que l'action du modafinil sur le cerveau implique deux mГ©canismes distincts, dont l'un est la stimulation des rГ©cepteurs de la dopamine et l'autre une modulation des rГ©cepteurs de la sГ©rotonine. Le nom Alertec est un mot-valise dГ©rivГ© de "Alerg" et du mot europГ©en "dormant". La dose quotidienne maximale chez les enfants ГўgГ©s de 1 Г 2 ans est de 50 mg. La narcolepsie est un trouble neurologique affectant environ 1 personne sur 2000. Prendre la dose du matin avant le petit-dГ©jeuner peut ГЄtre prГ©fГ©rable. Effets secondaires: Les nausГ©es et les maux de tГЄte sont frГ©quents. Le modafinil est mГ©tabolisГ© dans le foie et peut nГ©cessiter un ajustement de la dose chez les personnes atteintes d'une maladie du foie. Les doses initiales sont gГ©nГ©ralement de 50 mg Г 100 mg.
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