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Il est soluble dans l'eau et l'alcool et peu soluble dans la plupart des huiles, graisses et cires, et cristallise facilement. Alternatives au modafinil. Avant l'utilisation, les patients doivent ГЄtre examinГ©s pour les conditions susmentionnГ©es. Le modafinil, qui se lie Г©galement aux rГ©cepteurs de l'adГ©nosine A1, agit en bloquant ces rГ©cepteurs, ce qui entraГ®ne une augmentation des niveaux d'AMPc dans le cerveau. Au moins aux Г‰tats-Unis, le modafinil est considГ©rГ© comme une utilisation hors AMM pour l'amГ©lioration de la cognition, mais la recherche a montrГ© que le modafinil Г©tait utile Г cet Г©gard. Il a Г©tГ© dГ©montrГ© que le modafinil amГ©liore la rГ©ponse et l'humeur des personnes souffrant de dГ©pression majeure et a Г©tГ© utilisГ© dans le traitement de la somnolence diurne excessive due Г la dГ©pression majeure et Г l'apnГ©e obstructive du sommeil (OSA). Modiodal Drogue Une fois que le cerveau a Г©tГ© protГ©gГ© de la privation d'oxygГЁne, le modafinil se lie aux rГ©cepteurs de la dopamine sur les neurones voisins, en particulier les rГ©cepteurs D2. Sa formulation Г libГ©ration prolongГ©e (Modalert) est disponible aux Г‰tats-Unis et au Canada. Le modafinil peut interagir avec plusieurs autres mГ©dicaments. Le modafinil est Г©galement disponible au Royaume-Uni sous forme de mГ©dicament sur ordonnance uniquement, sous le nom de marque Provigil. Le modafinil est Г©galement utilisГ© comme traitement de la somnolence diurne excessive chez les personnes atteintes de narcolepsie. Modafinil fonctionne plus efficacement Г des doses plus Г©levГ©es. Il subit un mГ©tabolisme hГ©patique dans le foie et est excrГ©tГ© principalement dans l'urine. Le modafinil est susceptible d'agir sur un certain nombre de rГ©cepteurs diffГ©rents. Pour les troubles du sommeil liГ©s au travail postГ©, il a Г©tГ© dГ©montrГ© que le modafinil augmente la quantitГ© de sommeil non paradoxal pendant lequel le cerveau est dГ©clenchГ© et diminue le besoin de sommeil pendant l'Г©veil. Le modafinil peut provoquer des effets secondaires tels que des maux de tГЄte, des troubles du sommeil, des nausГ©es et des difficultГ©s Г uriner. Un tel danger pour la santГ© est maintenant en train d'ГЄtre enquГЄtГ©. L'important avec le modafinil est de ne pas faire de surdosage. Au niveau du neurone prГ©synaptique, la noradrГ©naline et la dopamine sont rГ©introduites dans le neurone prГ©synaptique pour maintenir les concentrations homГ©ostatiques de ces neurotransmetteurs. Cette heure et ce jour de prise, ainsi que la dose, varieront d'un individu Г l'autre. Il est approuvГ© aux Г‰tats-Unis pour traiter les troubles du sommeil liГ©s au travail postГ© ainsi que pour ГЄtre utilisГ© comme traitement d'appoint chez les personnes souffrant d'apnГ©e obstructive du sommeil.
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