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#4
Le modafinil a une affinité modérée pour le transporteur de la sérotonine et le transporteur de la noradrénaline, mais ne produit pas de réponse à ces sites. Le modafinil peut causer des problèmes d'attention et de mémoire chez certaines personnes. Une étude a montré qu'à la dose la plus élevée de 400 mg, 23 % des patients ont signalé des effets indésirables modérés ou graves, alors qu'à la dose la plus faible de 100 mg, seuls 2,5 % des patients ont signalé des effets indésirables. Certaines études suggèrent que le modafinil entraîne des battements cardiaques et une tension artérielle plus rapides qu'avec d'autres stimulants. Le modafinil se prend sous forme de mélange racémique. Provigil En France Il est généralement utilisé pour le traitement des troubles du sommeil liés au travail posté à une dose de 200 à 400 mg au coucher. Le modafinil est également disponible en tant que médicament générique. Le modafinil est un médicament utilisé pour favoriser l'éveil chez les personnes souffrant de troubles du sommeil, en particulier celles souffrant de narcolepsie ou de troubles du travail posté. Le modafinil est actif dans le cerveau en trente minutes et pénètre également dans le cœur et le foie. Il a été démontré que le modafinil améliore la vigilance, améliore les performances lors des tests d'attention soutenue et a été utilisé comme activateur cognitif. En 2002, l'agence française de protection des consommateurs a examiné deux recours collectifs contre deux fabricants de modafinil, dénonçant le traitement comme un médicament commercialisé sans prescription médicale. Il est également disponible en tant que médicament générique. La publication du résumé sur cette utilisation en décembre 2013 a détaillé un essai contrôlé randomisé (ECR) incluant 70 participants en bonne santé. Shionogi a commercialisé le modafinil pour son utilisation dans les troubles du sommeil liés au travail posté. Des trois isomères actifs, cependant, le R-modafinil a été le plus puissant dans les études sur le potentiel psychoactif chez la souris. Les chercheurs qui ont mené l'étude pensent que ces résultats représentent un test du stimulant sur les centres émotionnels du cerveau. La pilule est conçue pour être prise à la même heure chaque jour. Il agit principalement dans l'hypothalamus, où sa liaison à la dopamine-bêta-hydroxylase inhibe la dégradation de la dopamine.

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