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Le modafinil n'est pas recommandé chez les personnes souffrant de maladies cardiovasculaires, d'hypertension, d'hypothyroïdie, de convulsions et d'insuffisance rénale ou hépatique grave. Dans la plupart des pays, il est vendu comme médicament générique. Le modafinil n'est délivré que sur ordonnance. On pense qu'il s'agit d'un médicament améliorant la noradrénaline. Le modafinil offre un profil d'innocuité sur 24 heures avec une faible incidence de symptômes extrapyramidaux, de modifications cardiovasculaires et de toxicité comportementale aux doses utilisées pour traiter la narcolepsie. Deux de ces études ont pu recruter un groupe de personnes présentant des déficits importants des fonctions exécutives. Le modafinil est commercialisé sous le nom de Provigil aux États-Unis, au Canada, en Australie, en Nouvelle-Zélande, au Royaume-Uni et dans d'autres pays, et sous le nom de Modalert en Inde et en Argentine. Modafinil Ordonnance Le produit chimique est connu sous les noms triviaux d'Armodafinil ou simplement de Modafinil. De rares réactions dermatologiques graves peuvent survenir chez les personnes présentant des prédispositions génétiques et plus fréquemment chez les patients pédiatriques. Modafinil, modalert ou Provigil est un médicament qui stimule le système nerveux central et a été utilisé pour le traitement de la narcolepsie. Le modafinil n'est pas recommandé aux personnes souffrant de problèmes cardiaques et à celles qui fument. La prise du médicament avec ou sans nourriture n'a aucun effet cliniquement significatif sur l'absorption du médicament. Chaque participant a agi comme son propre témoin, effectuant les mêmes tâches avant et après la prise de modafinil. Le modafinil a été utilisé principalement dans le traitement des troubles du sommeil, mais on ne sait pas si le médicament est plus efficace que l'hygiène du sommeil. Les patients ne doivent pas prendre avec d'autres médicaments sans l'avis d'un médecin. En 2011, la société française qui détient les droits sur le modafinil, Centurion, recommandait la dose maximale à 400 mg, sans aucun avantage à 250 mg. Il y a eu au moins une étude sur la pharmacologie et la sécurité du modafinil pour une utilisation hors AMM dans le contexte de l'amélioration cognitive. Le modafinil est commercialisé sous les noms de Provigil, Citadine, Neuroonin et Armodafinil. Le modafinil peut fonctionner en stimulant les neurones dopaminergiques dans la région tegmentale ventrale du cerveau ainsi que le cortex frontal, le cortex cingulaire et le cervelet. Aux États-Unis, le Modafinil a été approuvé par la Food and Drug Administration (FDA) le 7 mai 2002. Le modafinil est composé d'un composé chimique et de méthylphénidate.
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