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C’est un terme large pour le médicament et ne spécifie pas de nom. Le modafinil est un peu plus puissant que l'amphétamine, l'isomère D étant environ 20 fois plus puissant que l'isomère L. Le modafinil est utilisé comme somnifère pour traiter la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. Ces neurotransmetteurs influencent les fonctions du système nerveux central, notamment les systèmes impliqués dans la stimulation de l'éveil. Aux États-Unis, il peut être vendu sous le nom de Modvigil par Sun Pharma Inc. Le principal mécanisme d'action du modafinil est une amélioration sélective du centre de l'éveil dans le SNC. Parmi les consommateurs de stimulants sur ordonnance, le modafinil n'est pas considéré comme un «euphorisant légal» en raison de son faible potentiel d'abus; il est plus souvent utilisé comme thérapie pour les troubles du sommeil. Modiodal Il est très soluble dans l'alcool (environ 3 grammes pour 100 millilitres) et soluble dans l'éther et les hydrocarbures. Les chercheurs ont émis l'hypothèse que le modafinil fonctionne comme un agent favorisant l'éveil. Il doit être démarré à faible dose et augmenté lentement jusqu'à sa dose optimale. Il n'est pas recommandé pour une utilisation chez les enfants de moins de 12 ans et ceux souffrant d'une maladie grave du foie ou des reins. Le modafinil est également utilisé pour le traitement de l'insomnie. Le modafinil sur ordonnance est disponible sous forme de médicament à libération prolongée et est généralement pris trois fois par jour. Le modafinil a été étudié pour son efficacité en tant que stimulant cognitif chez les personnes en bonne santé et les personnes handicapées. C'est un inhibiteur sélectif de non-recapture des transporteurs de la dopamine et de la sérotonine, et agit comme un modulateur allostérique du récepteur 5-HT 1A, une classe de récepteurs du neurotransmetteur sérotonine. Deuxièmement, le médicament stimule indirectement la partie des systèmes de neurotransmetteurs du cerveau responsable de l'envoi de messages depuis l'espace entre le cortex et le tronc cérébral, appelé système d'activation réticulaire. Le modafinil ne doit pas être pris avec ou peu de temps après un dépresseur du SNC, y compris les benzodiazépines (comme le Valium), les antidépresseurs ou d'autres médicaments qui provoquent une sédation. Il y a des suggestions qu'il peut être utile comme traitement pour divers troubles neurologiques. Bien que le modafinil soit chimiquement lié aux amphétamines, le modafinil n'est pas un stimulant et ne doit pas être utilisé pour traiter le trouble déficitaire de l'attention avec hyperactivité. Ces doses sont équivalentes à 100 mg d'amphétamine, 200 mg de méthylphénidate et 400 mg de méthylphénidate. Le modafinil est un médicament métabolique qui peut être éliminé de l'organisme par un simple test d'urine.
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