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#2
Bien que potentiellement dangereux, le modafinil n'est pas censГ© augmenter le risque d'accident vasculaire cГ©rГ©bral ou d'arrГЄt cardiaque. Le modafinil a un potentiel plus faible pour stimuler le systГЁme nerveux sympathique, bien que des effets sur le systГЁme endocrinien puissent se produire. Il est d'origine chinoise et figure sur la liste des substances interdites de l'Agence mondiale antidopage et son utilisation est Г©galement couverte par la Convention des Nations Unies contre le dopage dans le sport. Il n'est pas recommandГ© chez les personnes souffrant d'arythmie, d'hypertension artГ©rielle importante ou d'hypertrophie ventriculaire gauche. On pense que le modafinil agit en augmentant les niveaux de dopamine. Stimulant Intellectuel Sans Ordonnance Le composant principal est la forme R, reprГ©sentant environ 75 % du total, tandis que l'isomГЁre S reprГ©sente environ 5 %. Le modafinil est mГ©tabolisГ© par l'enzyme CYP2C19. Le modafinil a un effet plus rapide et est plus efficace que les autres stimulants pour traiter la somnolence. Il a d'abord Г©tГ© commercialisГ© en France sous le nom commercial de Cerexal. D'autres effets secondaires incluent des troubles du sommeil, une bouche sГЁche, un nez gonflГ©, une dГ©shydratation, une diarrhГ©e, une diminution de l'appГ©tit, des nausГ©es, des vomissements, de la constipation, de l'acnГ© et des dГ©mangeaisons. Des Г©tudes sur des cerveaux de rats ont montrГ© que le modafinil amГ©liorait sГ©lectivement l'Г©veil en activant les zones thalamique et hypothalamique et en diminuant l'activitГ© du striatum. Il n'a pas Г©tГ© dГ©montrГ© que des doses plus Г©levГ©es donnent de meilleurs rГ©sultats. Le modafinil est un agent favorisant l'Г©veil. L'un des aspects les plus importants du modafinil est ses effets sur le cerveau humain. Le modafinil est utilisГ© pour traiter les symptГґmes de la somnolence (p. п»їUne compilation de recherches universitaires indique que le modafinil amГ©liore l'Г©veil, l'attention, les performances cognitives, l'apprentissage, la mГ©moire et d'autres fonctions mentales. Le modafinil semble agir sur le faisceau noradrГ©nergique dorsal, ce qui a des effets sur l'excitabilitГ© corticale. Le modafinil semble agir principalement sur les zones du cerveau impliquГ©es dans l'Г©veil et l'activitГ© motrice.

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Depuis lors, le modafinil a Г©tГ© utilisГ© hors AMM pour traiter le trouble dГ©ficitaire de l'attention avec hyperactivitГ© (TDAH). Plusieurs Г©tudes ont Г©tabli une relation entre les actions du Modafinil et l'un de ces neurotransmetteurs, appelГ© acГ©tylcholine. Le modafinil est un mГ©dicament d'ordonnance. Certaines Г©tudes suggГЁrent que des doses plus Г©levГ©es allant jusqu'Г  800 mg peuvent ГЄtre efficaces. п»їLe modafinil peut ГЄtre pris sans Г©gard Г  la nourriture ou Г  l'heure de la journГ©e. Stimulant Intellectuel Sans Ordonnance Il a Г©tГ© proposГ© de fonctionner de maniГЁre similaire Г  la cafГ©ine chez l'homme en se liant aux rГ©cepteurs de l'adГ©nosine, en bloquant la liaison de l'adГ©nosine et en augmentant ainsi les niveaux de dopamine, un neurotransmetteur. Son mГ©canisme d'action n'est pas clairement compris, cependant, il a Г©tГ© dГ©montrГ© qu'il augmente l'activitГ© d'un neurotransmetteur appelГ© dopamine, et est souvent appelГ© inhibiteur de la recapture de la dopamine-norГ©pinГ©phrine (DNRi). Le modafinil est gГ©nГ©ralement bien tolГ©rГ©. Par exemple, et dans une utilisation hors AMM, il a Г©tГ© utilisГ© comme traitement du TDAH chez les enfants et chez les adultes, et pour la somnolence diurne excessive chez les personnes souffrant d'apnГ©e obstructive du sommeil. Il peut Г©galement provoquer des rГ©actions allergiques pouvant mettre la vie en danger, telles que le syndrome de Stevens-Johnson et l'anaphylaxie. On pense que les effets durables du mГ©dicament sont dus Г  sa capacitГ© Г  rester dans le cerveau pendant plusieurs heures aprГЁs l'ingestion orale. Le modafinil peut Г©galement provoquer une rГ©action paradoxale, notamment de l'insomnie, de l'apprГ©hension, des idГ©es suicidaires, de la confusion et des hallucinations. Il est recommandГ© d'arrГЄter de prendre du modafinil si vous prГ©sentez une Г©ruption cutanГ©e ou tout autre signe de rГ©action allergique. Il n'est pas approuvГ© pour le TDAH et la recherche sur son utilisation pour cette indication en est Г  ses dГ©buts. Certaines recherches ont laissГ© entendre que le modafinil pourrait ГЄtre aussi efficace que l'opioГЇde pour traiter les troubles du sommeil. Cette action provoque une augmentation des niveaux extracellulaires de dopamine, qui Г  son tour augmente l'acГ©tylcholine, entraГ®nant une augmentation de l'Г©veil.

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