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Modiodal Drogue
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Modiodal Drogue
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La FDA a approuvГ© Provigil en 1998 pour la narcolepsie. Ces pauses peuvent durer de quelques secondes Г plusieurs minutes, provoquant des arrГЄts respiratoires plusieurs fois pendant la nuit. Il est Г©galement utilisГ© hors AMM pour amГ©liorer l'Г©veil des travailleurs postГ©s et comme stimulant cognitif chez les personnes ayant un QI documentГ© infГ©rieur Г 75. De nombreuses autres Г©tudes rГ©centes ont Г©tГ© incohГ©rentes. Alors que les troubles du sommeil auxquels sont confrontГ©s les travailleurs postГ©s peuvent dans de nombreux cas ГЄtre gГ©rГ©s avec l'utilisation de stimulants, les mГ©dicaments qui ne font que rendre l'individu plus Г©veillГ© ne sont pas utiles pour Г©liminer les problГЁmes de sommeil sous-jacents. Le modafinil se prГ©sente sous forme de comprimГ©s ou de gГ©lules oranges ou jaunes. Modiodal Drogue Une dose typique est de 100 Г 400 mg pris une fois toutes les 24 heures. Le modafinil Г libГ©ration contrГґlГ©e est un agent inducteur d'Г©veil. Le modafinil est un stimulant non opioГЇde du systГЁme nerveux central qui rГ©duit la somnolence tout au long de la journГ©e et produit moins de somnolence diurne que la cafГ©ine, bien que ses effets sur la somnolence soient plus progressifs et durent gГ©nГ©ralement plus longtemps que ceux de la cafГ©ine. Il existe deux formes reconnues de narcolepsie, (1) qui est causГ©e par la perte de neurones Г hypocrГ©tine (orexine A) dans l'hypothalamus et (2) dans laquelle il existe un processus auto-immun conduisant Г une destruction des neurones Г hypocrГ©tine. Le modafinil a Г©tГ© dГ©veloppГ© pour le traitement de la narcolepsie, mais a Г©galement Г©tГ© utilisГ© pour traiter les travailleurs postГ©s qui ont des troubles du sommeil et pour amГ©liorer l'Г©veil pendant les voyages en avion. Les chercheurs qui ont menГ© l'Г©tude pensent que ces rГ©sultats reprГ©sentent un test du stimulant sur les centres Г©motionnels du cerveau. Il existe des preuves que le modafinil traite Г©galement les symptГґmes de somnolence de la narcolepsie. Le modafinil est un mГ©dicament Г action brГЁve avec une demi-vie plasmatique d'environ 90 minutes. L'hypothГЁse catГ©cholamine des effets du Modafinil est Г©tayГ©e par la recherche de son mГ©canisme d'action. Il est facilement absorbГ© dans le SNC ainsi que disponible dans le liquide cГ©phalo-rachidien.
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