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Une mГ©ta-analyse de ces essais a suggГ©rГ© que le modafinil est un traitement efficace pour l'amГ©lioration cognitive chez les personnes en bonne santГ©. On pense Г©galement qu'il agit sur le systГЁme cholinergique. L'utilisation de stimulants tels que le modafinil est gГ©nГ©ralement considГ©rГ©e comme le traitement de premiГЁre intention. Les effets secondaires du modafinil comprennent des maux de tГЄte, des troubles du sommeil, des nausГ©es et des problГЁmes de foie. Son utilisation dans le travail postГ© des pilotes et d'autres personnes ayant un travail qui les oblige Г passer de longues pГ©riodes Г©veillГ©es n'est pas controversГ©e. Il y a actuellement un manque de donnГ©es publiГ©es sur l'utilisation du modafinil pour une utilisation Г court terme et sur l'utilisation chez les patients pГ©diatriques, gГ©riatriques et enceintes. Les pilules de 200 mg contiennent une formulation lГ©gГЁrement diffГ©rente du mГ©dicament. Modiodal 200 Mg Le modafinil est utilisГ© pour traiter la somnolence diurne excessive rГ©sultant de la narcolepsie ou des troubles du sommeil liГ©s au travail postГ© et pour traiter l'apnГ©e obstructive du sommeil. Il est gГ©nГ©ralement pris sous forme de comprimГ©s. Dans les essais cliniques, le modafinil a montrГ© une amГ©lioration de l'attention soutenue et de la mГ©moire de travail, des scores plus Г©levГ©s aux tests de mГ©moire et une vigilance accrue. Au Royaume-Uni, le modafinil n'est approuvГ© que pour une utilisation dans le cadre d'un essai clinique et, en tant que tel, n'est pas disponible pour la recherche. Plusieurs patients des Г©tudes ont dГ©clarГ© se sentir mieux aprГЁs l'arrГЄt de l'utilisation. L'ingrГ©dient actif du modafinil est le citrate de modafinil. La dose quotidienne moyenne recommandГ©e est de 120 mg. Le modafinil est mГ©tabolisГ© dans le corps par clivage hydrolytique d'un groupe mГ©thyle pour former le M-151. Les autres ingrГ©dients comprennent la benzhydrocodone, la prednisolone, le paracГ©tamol et la cafГ©ine. Le modafinil est un inhibiteur sГ©lectif de la MAO-B. Il agit plus lentement chez les personnes souffrant d'apnГ©e obstructive du sommeil que chez celles qui n'en ont pas.
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