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01-09-2023, 11:24 PM
(This post was last modified: 01-09-2023, 11:24 PM by Modafinil 200.)
L'ingrГ©dient actif du modafinil, le modafinil, fait partie d'un groupe de mГ©dicaments connus sous le nom de psychostimulants non amphГ©tamines, ou NAP, qui agissent en stimulant le systГЁme nerveux central. On pense que les effets durables du mГ©dicament sont dus Г sa capacitГ© Г rester dans le cerveau pendant plusieurs heures aprГЁs l'ingestion orale. Il a Г©tГ© dГ©veloppГ© Г l'origine par des chercheurs de l'UniversitГ© de Bordeaux. Une Г©tude menГ©e au Japon, utilisant une combinaison de modafinil et de cafГ©ine, a rГ©vГ©lГ© que si l'intoxication subjective Г©tait rГ©duite, la performance sur les tГўches cognitives Г©tait en fait altГ©rГ©e. Le DAT est le seul transporteur capable d'Г©liminer la dopamine de la synapse, ce qui en fait un Г©lГ©ment important du systГЁme de signalisation de la dopamine. Les donnГ©es ont montrГ© que les patients qui prenaient du modafinil en plus de leurs somnifГЁres rГ©guliers Г©taient 60 % plus susceptibles d'avoir au moins une rГ©duction de 50 % de la somnolence, et significativement plus susceptibles d'avoir une rГ©duction d'au moins 50 % de la somnolence aprГЁs avoir pris du modafinil. Le modafinil est rГ©pertoriГ© dans le British National Formulary et son utilisation en Australie a Г©tГ© approuvГ©e par la Therapeutic Goods Administration (TGA). Modafinil Ordonnance Il est pris par la bouche. La dose ne doit pas ГЄtre augmentГ©e au-delГ si elle est mal tolГ©rГ©e. Le modafinil ne doit pas ГЄtre utilisГ© chez les femmes enceintes ou allaitantes et doit ГЄtre pris avec prudence avec les anticoagulants. Cela peut amГ©liorer la mГ©moire de travail. Le modafinil n'est pas recommandГ© chez les personnes ayant des antГ©cГ©dents de psychose ou de consommation de drogues induisant une psychose. En 1992, cette utilisation a Г©tГ© Г©tendue aux personnes diagnostiquГ©es avec un trouble du sommeil liГ© au travail postГ© qui avaient pris trois mois de vacances pendant au moins quatre ans et ne pouvaient plus fonctionner correctement pendant la journГ©e. Il est gГ©nГ©ralement bien tolГ©rГ©. Il y a eu des cas rapportГ©s oГ№ l'utilisation de Modafinil a conduit Г un arrГЄt cardiaque. Le modafinil est un nootropique, c'est-Г -dire qu'il amГ©liore la fonction cognitive. Il n'est pas clair si l'utilisation pendant la grossesse est sans danger. Le modafinil peut Г©galement agir comme antagoniste des rГ©cepteurs du glutamate. L'adamantane est une classe de composГ©s qui comprend l'amantadine. Il est Г©galement vendu sous le nom de marque Armodafinil par le fabricant Shionogi Inc.
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L'utilisation du modafinil doit ГЄtre limitГ©e Г 6 heures maximum par jour. Il n'est pas recommandГ© chez les personnes ayant des antГ©cГ©dents de psychose ou chez celles souffrant de troubles Г©pileptiques. Il augmente les niveaux d'Г©nergie et la concentration. Le modafinil n'affecte pas la liaison du dextromГ©thorphane au transporteur de noradrГ©naline. On pense que le modafinil favorise l'Г©veil en augmentant le nombre de sites rГ©cepteurs disponibles pour la dopamine (un neurotransmetteur dans le cerveau) dans le cerveau. Modafinil Ordonnance Les effets indГ©sirables graves plus rares comprennent l'anaphylaxie, le syndrome de Stevens-Johnson, les rГ©actions neuropsychiatriques et les hallucinations. Il est disponible aux Г‰tats-Unis, au Royaume-Uni, en Inde, au Bangladesh, en Australie, au BrГ©sil, au Canada, en Nouvelle-ZГ©lande, en NorvГЁge, au Pakistan, au Portugal et en Afrique du Sud. On pense que le modafinil est plus puissant et plus durable que les autres stimulants approuvГ©s pour ces indications. Modafinil a Г©tГ© vu pour augmenter les niveaux de NO dans le liquide cГ©phalo-rachidien. Le modafinil est utilisГ© pour traiter les troubles du sommeil liГ©s au travail postГ©, une condition dans laquelle les personnes travaillent pendant les heures normales de sommeil, mais ont du mal Г dormir ou Г s'endormir la nuit. Plus prГ©cisГ©ment, il augmente le nombre de neurones dans le cerveau antГ©rieur basal et amГ©liore la frГ©quence de dГ©clenchement des neurones. Modafinil est Г©galement commercialisГ© par Modafinil. Il est ne pas recommandГ© de modifier la posologie de Modafinil en fonction de votre Гўge ou de votre poids. Le modafinil n'est pas approuvГ© aux Г‰tats-Unis pour le traitement des troubles de l'Г©veil chez les enfants. Le modafinil doit ГЄtre pris pendant la journГ©e et ne doit pas ГЄtre pris plus d'une fois par jour. C'est un analogue isopropylique de la cafГ©ine. Un comitГ© consultatif de la FDA en 2013 a trouvГ© des preuves Г l'appui de son utilisation comme amГ©liorateur de performance diurne, avec la mise en garde qu'il pourrait ne pas ГЄtre efficace chez les personnes souffrant de troubles du sommeil. Le modafinil ne doit ГЄtre administrГ© que par un professionnel de la santГ©, car il peut ГЄtre mal utilisГ©. Ses effets secondaires sont gГ©nГ©ralement mineurs et touchent 10 Г 20 % des patients. Il n'est pas distribuГ© dans le systГЁme nerveux central et n'a pas de mГ©tabolites actifs.
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