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Le modafinil sur ordonnance est utilisГ© pour traiter les effets du manque de sommeil. Le modafinil est un mГ©dicament approuvГ© par la FDA utilisГ© pour traiter la narcolepsie et les troubles du sommeil liГ©s au travail postГ©. Il a Г©tГ© dГ©montrГ© qu'il a une longue demi-vie d'environ six Г neuf heures chez les personnes atteintes du polymorphisme CYP1A2. Le mГ©dicament est absorbГ© dans les intestins puis se dГ©place vers le cerveau, oГ№ il agit pour augmenter la vigilance. Des doses de 400 mg ou plus sont recommandГ©es. Le modafinil peut augmenter les effets d'autres stimulants du SNC, et on ne sait pas s'il a des effets similaires ou complГ©mentaires Г ceux de l'utilisation Г court terme d'amphГ©tamine et de mГ©thamphГ©tamine. Le modafinil est un inhibiteur sГ©lectif, rГ©versible et de haute affinitГ© de la recapture dopaminergique. Modafinil Sans Ordonnance Quebec Le modafinil agit en augmentant le temps passГ© Г©veillГ© en agissant directement sur le systГЁme nerveux central, principalement le systГЁme d'activation rГ©ticulaire et les structures de l'hypothalamus, et en augmentant les niveaux du neurotransmetteur acГ©tylcholine. Le nom chimique du dinitrate de modafinil est 1-(benzyl)-2-(diphГ©nylmГ©thyl)-1,3-dihydro-2H-benzimidazol-2-one 5,5-dioxyde, et son poids molГ©culaire est de 369. Le modafinil est un agoniste alpha-adrГ©nergique sГ©lectif et a une courte durГ©e d'action avec une demi-vie d'environ 6 heures et une durГ©e d'action entre 12 et 24 heures. Il peut Г©galement ГЄtre utilisГ© pour traiter les symptГґmes de l'apnГ©e obstructive du sommeil. Le modafinil est un inhibiteur de l'acГ©tylcholinestГ©rase, comme le donГ©pГ©zil et la rivastigmine. Avec son seuil thГ©rapeutique bas, de fortes doses du mГ©dicament peuvent provoquer des effets secondaires dГ©sagrГ©ables tels que nausГ©es, maux de tГЄte et insomnie. Le dГ©lai minimum recommandГ© pour commencer Г prendre le mГ©dicament est de deux semaines pour voir les effets. Les effets secondaires sont plus frГ©quents avec des doses plus Г©levГ©es et une utilisation prolongГ©e. Le mГ©dicament augmente Г©galement les niveaux de noradrГ©naline et d'acГ©tylcholine dans le cerveau des chiens. Le modafinil serait mГ©tabolisГ© par l'isoenzyme 3A4 du cytochrome hГ©patique P450 (CYP). Bien qu'il y ait un syndrome de sevrage aprГЁs l'arrГЄt du mГ©dicament, il semble ГЄtre lГ©ger. C'est plus long que certains autres stimulants. Le modafinil n'est pas recommandГ© chez les personnes ayant des antГ©cГ©dents de psychose ou de consommation de drogues induisant une psychose.
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Modafinil Sans Ordonnance Quebec - by Modafinil 200 - 01-10-2023, 12:58 PM
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