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(This post was last modified: 01-02-2023, 07:43 PM by Modafinil 200.)
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Des Г©tudes ont montrГ© que le modafinil gГ©nГ©rique est au moins aussi efficace que la version de marque pour l'usage auquel il est destinГ©. Il n'est pas recommandГ© chez les personnes souffrant d'arythmie, d'hypertension artГ©rielle importante ou d'hypertrophie ventriculaire gauche. Le terme modafinil est dГ©rivГ© du latin modus signifiant В« voie В» ou В« moyen В» et finis signifiant В« fin В». Le modafinil est Г©galement un agoniste de la vasopressine. Le modafinil se prend par voie orale. MalgrГ© son utilisation rГ©pandue, peu d'Г©tudes dГ©montrent son efficacitГ© comme activateur cognitif. La dose quotidienne maximale est de 1200 milligrammes (mg). Nootropique En France La dose quotidienne totale de modafinil sublingual (sous la langue) est de 200 mg. Il a Г©tГ© utilisГ© hors indication par certains qui pensent qu'il a le potentiel d'amГ©liorer considГ©rablement les performances sur le lieu de travail. Il peut Г©galement activer des neurones dans la zone prГ©optique/hypothalamus antГ©rieur, augmentant la dopamine. Le modafinil agit en augmentant la libГ©ration du neurotransmetteur acГ©tylcholine et de la sГ©rotonine chimique du cerveau, ce qui nous rend Г©veillГ©s. Le modafinil a Г©tГ© utilisГ© hors AMM pour le traitement de la fatigue chez les survivants du cancer, une population gravement privГ©e de sommeil. Le modafinil semble avoir peu d'effets secondaires, les effets secondaires les plus frГ©quemment signalГ©s Г©tant les maux de tГЄte, les nausГ©es et la somnolence. Le mГ©dicament est disponible en capsules de 40 mg, 100 mg, 200 mg et 400 mg. La proportionnalitГ© Г la dose de la pharmacocinГ©tique du modafinil 200 mg a Г©tГ© Г©tablie dans une Г©tude d'escalade de dose avec 684 volontaires sains. Mieux vaut prГ©venir que guГ©rir. La posologie rГ©guliГЁre est de 100 Г 200 mg; une utilisation prolongГ©e (plus de 14 jours) peut entraГ®ner une prise de poids, des troubles du sommeil, de la nervositГ©, des Г©tourdissements et de la somnolence. Le modafinil est un stimulant synthГ©tique qui augmente l'activitГ© de certains systГЁmes de neurotransmetteurs. Le modafinil se lie Г©galement Г la sous-unitГ© alpha-4 du rГ©cepteur nicotinique de l'acГ©tylcholine, et donc indirectement Г plusieurs rГ©cepteurs dont le rГ©cepteur dopaminergique D4, le rГ©cepteur sГ©rotonine-2 et 5-HT7 et le rГ©cepteur nicotinique de l'acГ©tylcholine.
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Il est souvent administré pour le traitement de la somnolence associée à la narcolepsie, au travail posté et à l'apnée obstructive du sommeil. L'étude a montré une augmentation significative de la vitesse de traitement de l'information. En 2016, le ministère français de la Santé et le Programme des Nations Unies pour le contrôle des drogues ont mené un essai clinique conjoint impliquant l'utilisation de Modafinil par des personnes atteintes de narcolepsie. Aux États-Unis, le modafinil est un principe actif du médicament Provigil (nom de marque), fabriqué par la société pharmaceutique Cephalon et commercialisé par Pfizer. Aux États-Unis, il est classé comme substance contrôlée de l'annexe IV, bien que sa classification a été remis en cause. En tant que l'un des médicaments les plus largement prescrits aux États-Unis, le modafinil peut être acheté auprès de divers fournisseurs. Nootropique En France Le monohydrate de chlorhydrate de modafinil et le citrate de modafinil sont respectivement ses sels de chlorhydrate et de citrate. Le modafinil n'est pas destiné à être pris avec d'autres médicaments stimulants, mais son utilisation peut interférer avec le cycle veille/sommeil naturel du corps. Cela serait alors pertinent pour influencer le comportement, l'humeur et d'autres actions du cerveau. Les effets secondaires courants comprennent les maux de tête, les nausées, les troubles du sommeil et une légère anxiété. Au Royaume-Uni, le modafinil est répertorié par le National Health Service (NHS) en tant que substance contrôlée de l'annexe 4. Le médicament n'est pas recommandé chez les enfants et chez les femmes enceintes ayant des antécédents de psychose. Le modafinil est commercialisé pour traiter la somnolence associée à la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. Le trouble du sommeil lié au travail posté est une condition dans laquelle les travailleurs postés développent des troubles du sommeil, comme une somnolence diurne excessive, qui interfère avec la concentration et la performance pendant leur travail posté. Le modafinil est généralement fourni sous forme de comprimé blanc à blanc cassé, à désintégration orale. Cela a probablement été utilisé pour justifier les informations sur l'innocuité et la demi-vie actuellement disponibles pour Provigil. La dose de modafinil doit être augmentée progressivement et les doses quotidiennes ne doivent jamais dépasser 400 mg. Les personnes atteintes de certaines conditions médicales peuvent être exposées à un risque accru d'effets secondaires ou de réactions plus graves lors de la prise de Modafinil. Caro et Ludwig Lewy. Modafinil traite également la somnolence excessive causée par l'apnée obstructive du sommeil.
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