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06-24-2023, 10:44 PM
(This post was last modified: 06-24-2023, 10:45 PM by Le Modafinil .)
Il a été démontré que le modafinil traverse la barrière hémato-encéphalique et est principalement actif lorsqu'il pénètre dans le cerveau. Les effets secondaires graves comprennent des réactions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson. Le modafinil semble agir en inhibant les récepteurs de l'adénosine du SNC, stimulant ainsi la libération d'acétylcholine et de noradrénaline par les cellules présynaptiques. Une étude menée auprès d'un groupe de volontaires sains a évalué la capacité du modafinil à améliorer la fonction psychomotrice. Son utilisation a été associée à moins de somnolence et à une amélioration des performances cognitives chez des volontaires sains en réponse à des doses élevées. Le nom modafinil vient de modum (latin pour "esprit") et fingas (latin pour "finir"). au Canada. Chez les animaux, cela se manifeste lorsque le modafinil augmente les niveaux de dopamine. Le modafinil agit sur les transporteurs de la dopamine dans le noyau accumbens et est également un agoniste du récepteur de la dopamine 2. Une étude de 2006 sur le modafinil pour le traitement de la dépression majeure a montré des résultats équivoques. Il a finalement été commercialisé pour son utilisation dans le traitement de la somnolence excessive, de l'insomnie primaire et des troubles du sommeil liés au travail posté. Dans les années 1990, une benzodiazépine apparentée aux meilleures propriétés pharmacologiques a été créée par le chercheur et universitaire français Claude Dumery, et ce nouveau composé, Armodafinil, a été approuvé aux États-Unis.
nootropique achat Comme l'amphГ©tamine, le modafinil augmente Г©galement les niveaux de noradrГ©naline et de 5-hydroxytryptamine (sГ©rotonine) et, contrairement Г l'amphГ©tamine, l'effet sur le systГЁme noradrГ©nergique dure beaucoup plus longtemps. Le modafinil est un agent favorisant l'Г©veil, qui augmente l'Г©veil par rapport Г celui d'autres stimulants. Le modafinil peut Г©galement influencer indirectement ces processus en limitant les effets des substances qui inhibent les neurotransmetteurs susmentionnГ©s. Le modafinil peut avoir des avantages pour les personnes souffrant d'apnГ©e du sommeil chronique lГ©gГЁre Г modГ©rГ©e, en particulier si l'apnГ©e du sommeil est dГ©jГ traitГ©e avec une pression nasale positive continue (nCPAP). Le modafinil est une poudre amorphe blanche Г blanc cassГ©. Le modafinil est un stimulant irrГ©versible Г action rapide. Pour de meilleurs rГ©sultats, il est pris dans l'heure qui prГ©cГЁde le coucher. Le modafinil est parfois utilisГ© comme outil scientifique pour Г©tudier les effets d'un sommeil excessif et ses effets cognitifs potentiels. L'ingrГ©dient actif, nommГ© CI-930, est le mГ©lange racГ©mique ou 50:50 de deux Г©nantiomГЁres, R-(+)-1-(benzyl-2,3-dimГ©thyl-phГ©noxy)-2-propanol et S-(-) -1-(benzyl-2,3-dimГ©thyl-phГ©noxy)-2-propanol. Le modafinil peut provoquer des effets secondaires lГ©gers Г modГ©rГ©s, et les mГ©dicaments peuvent devoir ГЄtre ajustГ©s chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques. Si vous avez pris une dose plus Г©levГ©e et qu'elle est efficace, il peut Г©galement ГЄtre prudent d'augmenter la dose, bien que vous deviez peut-ГЄtre surveiller vos symptГґmes pour tout effet secondaire. Le modafinil doit gГ©nГ©ralement ГЄtre pris Г jeun 1 Г 2 heures avant de prendre d'autres mГ©dicaments, y compris l'alcool. On pense que le modafinil active la libГ©ration de dopamine sur plusieurs sites du cerveau, y compris la substance noire et la zone tegmentale ventrale, et agit en augmentant la synthГЁse de dopamine. Il est Г©galement commercialisГ© par certaines sociГ©tГ©s pharmaceutiques en Inde, en Chine, aux Г‰mirats arabes unis et au Pakistan comme somnifГЁre. Les autres effets secondaires comprennent la perte d'appГ©tit, les nausГ©es et autres vomissements et la congestion nasale.
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Pour Г©viter les effets secondaires, n'utilisez pas plus de 100 milligrammes Г la fois et ne prenez jamais plus de quatre comprimГ©s par jour. On pense que le modafinil stimule directement la production d'AMPc (adГ©nosine monophosphate cyclique), qui produit ses effets stimulants. On ne sait pas encore exactement comment fonctionne le modafinil, mais il peut agir en augmentant la libГ©ration des neurotransmetteurs sГ©rotonine, noradrГ©naline et dopamine. C'est une cyclopentyl-dopamine, un type d'amphГ©tamine. Il est stable en prГ©sence de lumiГЁre et lorsqu'il est congelГ© Г -20 В°C. Le modafinil est le seul mГ©dicament sur ordonnance pouvant ГЄtre considГ©rГ© comme un traitement mГ©dical de la somnolence diurne excessive dans la narcolepsie. C'est un mГ©lange racГ©mique de deux Г©nantiomГЁres, la dextro- et la lГ©vodropropyl amphГ©tamine. Le mГ©dicament peut Г©galement ГЄtre utilisГ© pour les troubles du sommeil liГ©s au travail postГ©, une condition dans laquelle les personnes prГ©sentent des symptГґmes de narcolepsie mais sont obligГ©es de travailler normalement pendant leurs heures de sommeil. Le modafinil a un effet plafond et nГ©cessite donc des doses plus Г©levГ©es pour obtenir le mГЄme effet que lors de sa premiГЁre administration. Le modafinil a Г©tГ© brevetГ© pour la premiГЁre fois en France en 1976 par Robert Debiard. Une Г©tude suggГЁre que le modafinil augmente les niveaux de sГ©rotonine, mais cela reste Г confirmer. Le modafinil est une poudre cristalline blanche Г blanc cassГ©. Une Г©tude publiГ©e en 2000 a rГ©vГ©lГ© que le moment optimal pour prendre le modafinil est de 2 heures avant le coucher et a conclu que l'Г©veil tГґt dans la nuit augmentait aprГЁs le modafinil. D'autres membres comprennent l'armodafinil, le modafinil suvorexant et des agents favorisant l'Г©veil, tels que catapres et modalert.
nootropique achat Le taux d'effets secondaires sur le systГЁme nerveux central, comme la confusion, les Г©tourdissements et les maux de tГЄte, est faible. Aux Г‰tats-Unis, la Food and Drug Administration (FDA) n'a pas approuvГ© son utilisation pour des troubles spГ©cifiques, mais une nouvelle demande de nouveau mГ©dicament expГ©rimental (IND) a Г©tГ© approuvГ©e pour les gГ©lules Г libГ©ration prolongГ©e contenant 300 mg de chlorhydrate de modafinil (SILD-101). La somnolence excessive est une condition mГ©dicale dans laquelle une personne est incapable de rester Г©veillГ©e ou a du mal Г rester Г©veillГ©e tout en exГ©cutant une fonction quotidienne normale. Les indications courantes sont l'apnГ©e du sommeil, les troubles du sommeil liГ©s au travail postГ© et la narcolepsie. Il a une taille de particule infГ©rieure Г un micromГЁtre, ce qui est supГ©rieur Г la taille approximative d'une seule molГ©cule d'eau, ce qui le fait apparaГ®tre comme un solide cristallin. L'utilisation du modafinil pour l'amГ©lioration cognitive dans la SEP est actuellement considГ©rГ©e comme expГ©rimentale. Au Royaume-Uni, dans le traitement des troubles du sommeil liГ©s au travail postГ©, le modafinil est approuvГ© pour une utilisation chez les enfants jusqu'Г l'Гўge de 17 ans (pour ceux qui sont capables de prendre des mГ©dicaments par voie orale). Le modafinil est gГ©nГ©ralement disponible sous forme de comprimГ©s de 100 mg, la dose suggГ©rГ©e Г©tant de 200 mg. Certaines personnes ont signalГ© une diminution de l'efficacitГ© du mГ©thylphГ©nidate et ont Г©tГ© dГ©placГ©es vers une dose plus faible afin de maintenir leur niveau de fonction. Ces formulations ont Г©tГ© approuvГ©es par la FDA amГ©ricaine en 1996.
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