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Le modafinil se prend par voie orale. Le modafinil est approuvГ© pour le traitement des troubles du sommeil liГ©s au travail postГ©, de la somnolence diurne excessive associГ©e Г  la narcolepsie et Г  l'apnГ©e obstructive du sommeil (AOS), ainsi que pour aider Г  maintenir l'Г©veil chez les patients ayant des antГ©cГ©dents d'apnГ©e obstructive du sommeil (AOS) lorsque les traitements standard sont insuffisant. Contrairement Г  l'amphГ©tamine, le modafinil ne traverse pas la barriГЁre hГ©mato-encГ©phalique, empГЄchant ainsi la stimulation dopaminergique de type mГ©thamphГ©tamine. En raison de problГЁmes de prise de poids et des dangers d'une consommation excessive de cafГ©ine ou d'amphГ©tamines, l'utilisation du modafinil est toujours limitГ©e par la FDA au traitement de la narcolepsie, et il n'a Г©tГ© approuvГ© pour cette utilisation qu'aux Г‰tats-Unis. Son efficacitГ© dans le traitement de ces indications a Г©tГ© Г©valuГ©e dans plusieurs Г©tudes contrГґlГ©es. Modiodal Generique L'effet du modafinil dure environ quatre Г  six heures. Il peut avoir des effets nГ©gatifs sur les paramГЁtres cardiovasculaires et la tension artГ©rielle. C'est un mГ©dicament sympathomimГ©tique qui favorise l'Г©veil en augmentant les niveaux d'Г©pinГ©phrine et de noradrГ©naline dans le cerveau. Le traitement au modafinil peut Г©galement entraГ®ner une augmentation des niveaux de sГ©rotonine dans le cerveau en inhibant et/ou en empГЄchant l'enzyme MAO. Le modafinil est un composГ© racГ©mique, ce qui signifie qu'il y a des quantitГ©s Г©gales de molГ©cules gauchers et droitiers dans le corps. En augmentant l'acГ©tylcholine, le modafinil, comme d'autres mГ©dicaments tels que les inhibiteurs de l'acГ©tylcholine estГ©rase, rend les actions du systГЁme nerveux plus fluides et efficaces. C'est un dГ©rivГ© de la phГ©nylcyclopropylamine. Le modafinil est un agent nootrope et amГ©liorant l'Г©veil, utilisГ© pour traiter la somnolence diurne excessive associГ©e Г  la narcolepsie, l'apnГ©e du sommeil, le travail postГ© et d'autres troubles. Le modafinil a Г©tГ© Г©tudiГ© dans un essai randomisГ© en double aveugle, contrГґlГ© par placebo, comparant le modafinil et les amphГ©tamines. Les patients prenant du modafinil avant le coucher peuvent avoir besoin de rГ©duire la quantitГ© totale prise ou d'Г©viter de prendre du modafinil juste avant le coucher. Les mГ©dicaments contiennent 100 mg Г  200 mg de modafinil. Modafinil-SR et Modafinil-LA sont la mГЄme substance avec la seule diffГ©rence Г©tant la prГ©sence de diffГ©rents sels. Le mГ©canisme d'action du modafinil est similaire Г  celui du mГ©thylphГ©nidate mais avec un dГ©lai d'action plus long et une durГ©e d'action plus longue. Il est commercialisГ© sous les noms de marque Provigil (Finzel) en Australie, au Canada, au Royaume-Uni, en France et en Afrique du Sud, et sous forme injectable en Italie. Il est gГ©nГ©ralement bien tolГ©rГ©, mais a des effets secondaires dГ©sagrГ©ables, notamment des maux de tГЄte, des troubles du sommeil et des nausГ©es.

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Cependant, certaines de ses propriГ©tГ©s favorisant l'Г©veil semblent ГЄtre liГ©es Г  sa non sГ©lectif activitГ© dans le cerveau. Il peut avoir des effets nГ©gatifs sur les paramГЁtres cardiovasculaires et la tension artГ©rielle. Cela peut contribuer aux propriГ©tГ©s "d'amГ©lioration de l'Г©veil" du mГ©dicament. Depuis son apparition sur le marchГ© amГ©ricain, le modafinil est prГ©sentГ© comme un В« mГ©dicament intelligent В». Peu de gens ressentent des effets secondaires lors de l'utilisation de Modafinil. Modiodal Drogue Des Г©tudes animales ont montrГ© que le modafinil facilite l'acquisition et la persistance de compГ©tences complexes et amГ©liore les performances de la mГ©moire et d'autres fonctions cГ©rГ©brales, notamment l'attention et la discrimination. Chez les patients atteints de narcolepsie, le modafinil amГ©liore le cycle veille-sommeil, diminue la somnolence diurne et la cataplexie. Selon l'American Academy of Sleep Medicine, le modafinil est utilisГ© pour favoriser la vigilance chez les personnes atteintes de SWSD, de narcolepsie et d'hypersomnie idiopathique. Son efficacitГ© est discutable en raison du manque de preuves dans ce domaine. Le modafinil n'est pas un traitement de premiГЁre intention de la narcolepsie et peut l'aggraver. Des effets secondaires psychiatriques peuvent survenir chez les personnes ayant des antГ©cГ©dents de psychose ou de trouble bipolaire. La recherche a montrГ© que la prise de modafinil avant un grand Г©vГ©nement peut amГ©liorer les performances intellectuelles. Il est vendu aux Г‰tats-Unis en tant que mГ©dicament dГ©livrГ© uniquement sur ordonnance. Une fois que le modafinil se lie Г  un rГ©cepteur, cela empГЄche le corps de libГ©rer de la dopamine. Sa demi-vie est gГ©nГ©ralement plus faible chez les personnes ГўgГ©es. Le modafinil a une biodisponibilitГ© orale Г©levГ©e (F = 95 %) et est bien absorbГ©. Cela augmente la concentration de dopamine dans la synapse, ce qui amГ©liore l'efficacitГ© des neurotransmetteurs au niveau des rГ©cepteurs post-synaptiques.

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