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Des effets indГ©sirables graves tels qu'un gonflement du visage, des difficultГ©s respiratoires, des douleurs thoraciques, des troubles cutanГ©s ou musculaires et des problГЁmes de comportement peuvent survenir. La substance active du mГ©dicament est le modafinil; il est librement soluble dans l'alcool et le dimГ©thylsulfoxyde, modГ©rГ©ment soluble dans l'eau et pratiquement insoluble dans les graisses. Le fonctionnement de Modafinil n'est pas encore entiГЁrement compris. Le modafinil est disponible en formulations Г libГ©ration immГ©diate (ou В« Г libГ©ration rГ©guliГЁre В») et Г libГ©ration modifiГ©e (ou В« Г libГ©ration prolongГ©e В»). Les effets secondaires courants incluent la gueule de bois, la somnolence ou une sensation d'Г©veil excessif. La cataplexie commence gГ©nГ©ralement Г s'attГ©nuer aprГЁs deux Г six semaines d'utilisation continue. C'est un traitement approuvГ© par la FDA pour la narcolepsie. Il est classГ© dans la famille des stimulants du SNC et comprend les amphГ©tamines, les cathinones et le mГ©thylphГ©nidate. Aux Г‰tats-Unis, les comprimГ©s se distinguent par une Г©tiquette mettant en garde contre les effets secondaires du modafinil, ainsi qu'une liste des conditions mГ©dicales pour lesquelles le mГ©dicament n'est pas indiquГ©, car cela peut indiquer une mauvaise utilisation intentionnelle du produit. Il peut Г©galement augmenter les effets inhibiteurs du GABA, augmentant ainsi le sommeil via l'action du GABA sur le thalamus. provigil france Le modafinil est un stimulant du systГЁme nerveux central qui active les rГ©cepteurs de la dopamine. En 2019, l'American Psychiatric Association a ajoutГ© l'insomnie Г sa liste de problГЁmes de santГ© mentale suspectГ©s, mais non encore Г©tablis, pour lesquels une aide professionnelle peut ГЄtre recherchГ©e. Dans une Г©tude distincte, le modafinil a Г©tГ© administrГ© Г 22 sujets masculins avec des rГ©sultats de tests de latence d'endormissement multiples (MSLT) de plus de cinq minutes. La dose initiale recommandГ©e de modafinil est de 200 Г 400 mg par jour, divisГ©e en deux ou trois doses. L'ingrГ©dient actif du modafinil, le modafinil, fait partie d'un groupe de mГ©dicaments connus sous le nom de psychostimulants non amphГ©tamines, ou NAP, qui agissent en stimulant le systГЁme nerveux central. Le mГ©canisme d'action du modafinil n'est pas connu car il ne s'agit pas d'un analogue de l'amphГ©tamine, mais plusieurs actions possibles peuvent ГЄtre impliquГ©es, telles que :п»їLe modafinil a Г©tГ© approuvГ© par la Food and Drug Administration pour le traitement de la somnolence diurne excessive associГ©e Г la narcolepsie et aux troubles du sommeil liГ©s au travail postГ©. Le modafinil agit en augmentant le niveau d'adГ©nosine, le messager chimique naturel qui aide les neurones Г communiquer. Cette recherche a Г©tГ© mitigГ©e et une enquГЄte plus approfondie est nГ©cessaire pour dГ©terminer l'efficacitГ© du modafinil en tant que nootropique. L'effet de ces doses est beaucoup plus important que l'effet de doses plus faibles, et ils peuvent provoquer des effets secondaires considГ©rables s'ils sont consommГ©s en plus grande quantitГ©. Les interactions sont rГ©sumГ©es par pharmacologie clinique et thГ©rapeutique. Le modafinil est classГ© comme un stimulant du systГЁme nerveux central. Il est vendu sous la marque Provigil.
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