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Le modafinil a une courte demi-vie plasmatique de 30 Г 90 minutes et est mГ©tabolisГ© par la bГЄta-oxydation des acides gras. Le modafinil peut provoquer une somnolence chez certains patients. Dans un essai Г double insu et contrГґlГ© par placebo chez 170 patients, le mГ©dicament a amГ©liorГ© la qualitГ© du sommeil, la latence du sommeil, l'efficacitГ© du sommeil et les temps de rГ©veil, et a rГ©duit le rГ©veil aprГЁs le dГ©but du sommeil. Le modafinil agit en augmentant la quantitГ© de dopamine, un neurotransmetteur, libГ©rГ©e dans le cerveau. Cela aurait pour effet d'augmenter ou de diminuer la quantitГ© de dopamine dans le cerveau. Il ne semble pas ГЄtre un substrat pour le transporteur d'anions organiques 3. Il est gГ©nГ©ralement bien tolГ©rГ©, avec des effets secondaires possibles, notamment des maux de tГЄte, des troubles du sommeil et des nausГ©es. Le modafinil est pris par voie orale Г une dose de 200 mg. Cependant, les Г©tudes ont souvent rГ©vГ©lГ© que l'effet n'Г©tait que dans les heures du matin suivant la prise et que l'effet Г©tait faible par rapport aux effets de l'amphГ©tamine ou de la cafГ©ine. Cela devrait ГЄtre pris avant d'aller au lit. Au Royaume-Uni et en Europe, le modafinil est approuvГ© pour le traitement de la somnolence excessive chez les adultes atteints de narcolepsie.
Stimulant Intellectuel Sans Ordonnance La forme liquide est de 100 mg/10 ml. Des études montrent que le modafinil agit dans le cerveau à travers deux systèmes différents. On ne sait pas s'il est sans danger pendant la grossesse. La dopamine joue un rôle primordial dans le cerveau en termes d'éveil et d'activité musculaire, et est responsable de la production de la sensation d'éveil dans le cortex préfrontal. On pense que cette action est médiée en partie par la libération d'acides aminés excitateurs, en particulier les neurotransmetteurs glutamatergiques (via la régulation à la hausse des transporteurs de glutamate), ainsi que par une synthèse accrue du neurotransmetteur inhibiteur acide gamma-aminobutyrique (GABA). Le médicament peut être pris par voie orale ou par application sublinguale. L'interaction du modafinil avec le transporteur de la dopamine (DAT) est beaucoup plus importante que celle d'un bloqueur DAT similaire, tel que l'amphétamine, ce qui peut renforcer les actions physiologiques du modafinil. Il existe plusieurs formes posologiques différentes; cependant, il a été constaté que les doses varient considérablement dans le traitement de troubles du sommeil spécifiques. Le modafinil est l'ingrédient actif de Nuvigil, Provigil, Ritalin XR et Adrafinil, entre autres. Il est disponible sous forme de comprimés, de comprimés pelliculés, de gélules, de suspensions et de sirops. Les essais cliniques chez les enfants, cependant, n'étaient pas bien conçus et les effets de l'utilisation par les enfants et les adolescents peuvent ne pas être connus avant des années.
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