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Le modafinil stimule le systГЁme nerveux central et agit comme un stimulant de l'Г©veil en augmentant les niveaux d'histamine dans le cerveau. Certains de ces effets sont spГ©cifiques aux personnes atteintes de narcolepsie, d'autres sont plus gГ©nГ©raux. Les personnes utilisant le modafinil pour des problГЁmes de travail postГ© doivent Г©viter de conduire ou d'utiliser des machines dangereuses pendant qu'elles sont sous modafinil. Le modafinil est rapidement absorbГ© aprГЁs prise orale avec un Tmax d'environ 3 Г 6 heures. Une fois que le mГ©dicament a Г©tГ© dГ©couvert, il a rapidement Г©tГ© retirГ© de l'utilisation clinique car il provoquait une rigiditГ© sГ©vГЁre de la mГўchoire, y compris l'Г©rosion permanente de l'os. Il est pratiquement insoluble dans l'eau et soluble dans l'alcool, l'Г©ther, le mГ©thanol et l'acide chlorhydrique diluГ©. Le modafinil est utilisГ© pour traiter la somnolence (hypersomnie) rГ©sultant d'une insuffisance de sommeil naturel et est indiquГ© dans le traitement de la narcolepsie et des troubles du sommeil liГ©s au travail postГ©, pour amГ©liorer l'Г©tat d'Г©veil et la vigilance diurne lors de voyages Г travers diffГ©rents fuseaux horaires, pour amГ©liorer l'Г©tat de veille chez les personnes souffrant de l'apnГ©e obstructive du sommeil et pour traiter les patients souffrant d'un trouble dГ©ficitaire de l'attention avec hyperactivitГ© (TDAH). C'est aussi un excellent activateur de concentration. Alors que d'autres mГ©dicaments stimulants tels que le Ritalin ont dГ©montrГ© des effets similaires d'amГ©lioration des performances Г court terme sur une variГ©tГ© de tГўches telles que les tests de mГ©moire, le Modafinil n'a pas eu autant de succГЁs. Le modafinil aide Г©galement Г rГ©duire la faible pression du sommeil, ce qui permet au corps de dormir davantage avant de se rГ©veiller. Le modafinil semble augmenter les taux sanguins de l'hormone sГ©rotonine. La FDA a publiГ© une dГ©claration indiquant qu '"il n'y avait aucune preuve d'Г©vГ©nements indГ©sirables graves dans le nombre limitГ© d'Г©tudes cliniques sur le modafinil. Le modafinil amГ©liore l'Г©veil des patients souffrant de troubles du sommeil liГ©s au travail postГ© et rГ©duit la fatigue et la somnolence associГ©es Г l'apnГ©e obstructive du sommeil.
Provigil Achat Il a été démontré qu’il agit sur les zones cérébrales suivantes : Dopamine - le neurotransmetteur "de bien-être". Les effets du modafinil sur le système d'activation réticulaire dans le tronc cérébral et le système d'acétylcholine peuvent également contribuer à ses effets d'amélioration de l'éveil. Le modafinil est utilisé hors AMM comme prétendu activateur cognitif pour améliorer l'éveil. Le modafinil a également une faible nootropique (renforcement du cerveau) propriétés. Le modafinil est un mélange racémique de deux isomères optiques, ou énantiomères, le R-(+)-modafinil et le S-(-)-modafinil. Le modafinil se prend par voie orale. Le modafinil fonctionne comme un agoniste modéré des récepteurs de la dopamine, qui peut augmenter la dopamine dans les zones du cerveau qui contrôlent le sommeil, l'éveil, la motivation et l'éveil, dans l'artère cérébrale moyenne et l'hippocampe. Les effets du modafinil se manifestent en trois à quatre heures. Le modafinil est environ 1 000 fois plus puissant que l'amphétamine pour élever les niveaux d'acétylcholine dans le cerveau. Le modafinil est fabriqué sous forme de poudre cristalline blanche ou beige clair à blanc cassé. Jusqu'à présent, le modafinil est l'un des deux médicaments qui a fait l'objet du plus grand nombre d'études de recherche. Le modafinil a été développé dans les années 1970 par les laboratoires Michel Jouvet et Lafon et a été approuvé pour un usage médical aux États-Unis en 1998. Les deux voies d'action différentes sont la raison de l'utilisation de ce médicament comme traitement de plusieurs troubles. Seul le principe actif, le N-[benzyl-2,3-dihydro-5-méthoxy-1H-1,4-benzodiazépin-2-yl]acétamide, est le même. Aux États-Unis, le modafinil est disponible en tant que médicament générique pour le traitement de la somnolence associée à la narcolepsie ou à d'autres troubles.
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