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#6
Le modafinil n'est pas considГ©rГ© comme une alternative sГ»re Г  la consommation de cafГ©ine et d'autres stimulants pendant la grossesse ou l'allaitement. Ce mГ©tabolite est inactif. Cela peut Г©galement amГ©liorer la mГ©moire de travail. Le modafinil stimule efficacement ces centres "du sommeil", prГ©venant la somnolence lorsque l'on a besoin de se rГ©veiller et de gagner de l'Г©nergie. L'une des formes de modafinil est le modafinil xr, une version Г  libГ©ration prolongГ©e une fois par jour du mГ©dicament qui permet de rester Г©veillГ© pendant 24 heures. Les personnes atteintes de narcolepsie peuvent gГ©nГ©ralement s'endormir aprГЁs environ 20 minutes d'Г©veil et ne pas ГЄtre en mesure de rГ©pondre aux stimuli. L'Г©nantiomГЁre S ne produit pas de rГ©actions Г  mГ©diation adrГ©nergique et ne crГ©e pas de dГ©pendance. Dans le modafinil, l'actif est l'acide D-mГ©tafolinique. Le modafinil peut Г©galement affecter d'autres mГ©dicaments qui contiennent les mГЄmes produits chimiques que le modafinil. Aux Г‰tats-Unis, il est indiquГ© pour le traitement de la narcolepsie, des troubles du sommeil liГ©s au travail postГ© et de l'apnГ©e obstructive du sommeil. Vous pouvez Г©galement obtenir du Modafinil auprГЁs de distributeurs tiers. Le mГ©canisme d'action exact dans le cerveau est inconnu. Des Г©tudes chez la souris ont montrГ© que le modafinil augmente la libГ©ration de dopamine par les neurones du mГ©sencГ©phale. Ces stimulants augmentent le flux sanguin dans les zones du cerveau impliquГ©es dans l'Г©veil. Le modafinil influence le systГЁme de rГ©gulation du sommeil et peut augmenter l'Г©veil et la vigilance. modafinil belgique La liaison au site de liaison du modafinil va stimuler le rГ©cepteur, provoquant une augmentation de l'action du neurotransmetteur GABA, conduisant Г  un effet inhibiteur du sommeil plus fort, et donc moins de somnolence diurne. Certaines personnes peuvent bГ©nГ©ficier du modafinil et cela dГ©pend si leur corps mГ©tabolise le modafinil diffГ©remment. Il n'est pas recommandГ© de prendre plus de 400 mg par jour. Le rГ©sultat de ce mГ©tabolisme est une augmentation du normodafinil, qui est le mГ©tabolite pharmacologiquement actif. La dose de modafinil est gГ©nГ©ralement comprise entre 100 et 200 mg par jour. L'effet de ceci est gГ©nГ©ralement observГ© dans les 30 minutes suivant l'administration, bien que cela puisse prendre jusqu'Г  1 heure pour atteindre son apogГ©e. On pense que le modafinil amГ©liore l'Г©veil en modifiant l'action de l'un de ces produits chimiques, la dopamine. Le modafinil est un analogue synthГ©tique du neurotransmetteur adГ©nosine. En 2013, Provigil a gГ©nГ©rГ© des revenus d'environ 1,9 milliard de dollars pour Sun Pharma. Modafinil est le seul mГ©dicament approuvГ© par la FDA approuvГ© pour une utilisation dans le traitement de la somnolence excessive associГ©e Г  la narcolepsie. La narcolepsie est un trouble neurologique affectant l'Г©quilibre et la coordination entre les deux hГ©misphГЁres cГ©rГ©braux. Il devient actif lorsqu'une personne est Г©veillГ©e. Il a Г©tГ© portГ© Г  l'attention pour la premiГЁre fois en 1992, lorsque le modafinil a Г©tГ© utilisГ© comme stimulant de l'Г©veil par un groupe de soldats qui avaient souffert de privation de sommeil en raison d'un rГ©gime d'entraГ®nement intensif. Le modafinil peut avoir d'autres utilisations potentielles, comme dans le dysfonctionnement sexuel. Le modafinil est le seul stimulant prescrit pour le traitement du trouble dГ©pressif majeur en dehors d'un essai clinique contrГґlГ© ; Г  partir de 2019, les seules autres Г©tudes contrГґlГ©es ont Г©tГ© rГ©alisГ©es chez des volontaires sains.

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#7
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#8
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#9
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#10
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