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#6
Le modafinil se prend par voie orale. La dose peut ГЄtre augmentГ©e progressivement jusqu'Г  la dose cible. Son mГ©canisme d'action n'est pas clair et on a Г©mis l'hypothГЁse que le modafinil amГ©liore l'Г©veil par de multiples voies (par exemple, en modulant la libГ©ration de neurotransmetteurs favorisant l'Г©veil, comme l'orexine) ou par des voies uniques au modafinil. Le modafinil n'est pas recommandГ© chez les personnes souffrant d'hypertension sГ©vГЁre ou de problГЁmes cardiaques, de maladies hГ©patiques ou rГ©nales ou de certaines autres mutations gГ©nГ©tiques. La dose habituelle est de 100 mg pris 1,5 heure avant le coucher. Chez la souris, le modafinil s'est avГ©rГ© deux fois plus puissant que le diazГ©pam, un autre sГ©datif gГ©nГ©ral et un anxiolytique. Le modafinil est un inhibiteur hautement sГ©lectif de la recapture de la dopamine. Le modafinil influence Г©galement les niveaux d'hormone de croissance hypophysaire dans le cerveau, ce qui augmente les niveaux d'hormone de croissance dans le sang. Pour Г©viter les effets secondaires, les personnes prenant des mГ©dicaments pouvant interagir avec les amphГ©tamines ou pour maintenir le sommeil doivent ГЄtre averties de l'utilisation du modafinil. Le modafinil est pris par voie orale Г  une dose de 200 mg. Cependant, des effets secondaires sont possibles si le mГ©dicament est utilisГ© de maniГЁre inappropriГ©e ou Г  fortes doses. Au Royaume-Uni, il n'est pas approuvГ© comme traitement pour toute condition mГ©dicale. Un mГ©dicament apparentГ©, l'armodafinil (Г©galement appelГ© Nuvigil, Nuvlin et Provigil R), est un analogue du modafinil avec une demi-vie lГ©gГЁrement plus longue, qui est approuvГ© par la FDA pour une utilisation comme somnifГЁre nocturne dans la narcolepsie. Le modafinil est Г©galement un inhibiteur sГ©lectif de la recapture du neurotransmetteur inhibiteur acide gamma-aminobutyrique (GABA). ou acheter modafinil Deux Г©tudes ont montrГ© un potentiel d'amГ©lioration de l'Г©veil chez les personnes souffrant d'apnГ©e obstructive du sommeil, et un essai a dГ©montrГ© des rГ©sultats bГ©nГ©fiques dans d'autres troubles neurologiques, y compris chez les personnes atteintes de TDAH et de la maladie de Parkinson. D'autres membres comprennent l'armodafinil, le modafinil suvorexant et des agents favorisant l'Г©veil, tels que catapres et modalert. Il n'est pas utilisГ© comme somnifГЁre, mais pour les personnes qui essaient de rester Г©veillГ©es afin de travailler ou d'autres activitГ©s. ГЂ court terme, cela peut ГЄtre trГЁs utile, mais avec le temps, cela conduit Г  un besoin de quantitГ©s croissantes de mГ©dicament pour conserver cette motivation. Le modafinil a Г©tГ© dГ©veloppГ© dans les annГ©es 1970 par le chimiste Pierre Modave, puis dГ©veloppГ© par Michel Jouvet Г  l'Institut Caven-de-Boulogne en France, oГ№ il a Г©tГ© utilisГ© pour la premiГЁre fois chez les personnes atteintes de narcolepsie. Ceux-ci incluent des maux de tГЄte anxieux, nerveux, bien Г©veillГ©s et persistants. Il a Г©tГ© rapportГ© qu'il amГ©liore l'Г©veil et la concentration chez les patients narcoleptiques, rГ©duit les sensations de fatigue et augmente la capacitГ© d'attention chez les patients souffrant d'apnГ©e du sommeil. On pense que le modafinil a une faible affinitГ© pour les rГ©cepteurs de l'histamine (H1), les rГ©cepteurs de la dopamine (D2 et D4) et une affinitГ© substantielle pour les rГ©cepteurs de l'adГ©nosine. Pour lutter contre la narcolepsie, le modafinil est administrГ© aux patients avant l'heure du coucher. Le modafinil peut ГЄtre administrГ© par voie orale ou par inhalation. Il peut avoir des effets nГ©gatifs sur les paramГЁtres cardiovasculaires et la tension artГ©rielle. Le modafinil peut causer des problГЁmes d'attention et de mГ©moire chez certaines personnes.

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Deux études ont montré un potentiel d'amélioration de l'éveil chez les personnes souffrant d'apnée obstructive du sommeil, et un essai a démontré des résultats bénéfiques dans d'autres troubles neurologiques, y compris chez les personnes atteintes de TDAH et de la maladie de Parkinson. Une expérience récente menée par des chercheurs de l'Université du Michigan a révélé que des souris âgées qui recevaient du modafinil pendant un cycle lumière-obscurité de 12 heures/12 heures étaient capables de mieux performer que des souris non traitées dans une série de tests neuropsychologiques. Le modafinil est principalement utilisé pour traiter les troubles du sommeil, notamment la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. En octobre 2019, les National Institutes of Health ont déclaré que les "amplificateurs de vision/de rêve artificiels" pourraient améliorer l'efficacité des médicaments déjà utilisés pour traiter les personnes souffrant de dépression et d'autres affections. Le modafinil ne semble pas se lier au système sérotoninergique. Testez le médicament avec quelques doses avant de le prendre tous les jours. Certaines personnes atteintes de TDAH ont bénéficié de l'utilisation du modafinil pour améliorer leur capacité de concentration, mais son utilisation nécessite une étude plus approfondie. Il existe plusieurs façons possibles d'agir sur le modafinil pour augmenter l'éveil et la vigilance. Modafinil n'a pas été entièrement analysé pour son mécanisme d'action. Ses propriétés "favorisant l'éveil" ne sont pas altérées par des doses régulières d'alcool. Cependant, de nombreux médecins signalent des résultats positifs lors de l'utilisation de Modafinil pour diverses conditions médicales, et il est couramment utilisé hors AMM par les médecins pour traiter ces conditions. Chez l'homme, le modafinil est rapidement absorbé et atteint des concentrations plasmatiques maximales en 2 heures environ. Le modafinil est utilisé pour traiter la somnolence due à la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. Les patients pédiatriques prenant du modafinil, généralement considéré comme sûr pour ce groupe d'âge, ont présenté des effets secondaires plus graves, en particulier des réactions dermatologiques, notamment des éruptions cutanées graves et le syndrome de Stevens-Johnson, ainsi que des hallucinations. ou acheter modafinil Aux États-Unis, le modafinil est un médicament délivré uniquement sur ordonnance. Quels sont les avantages du modafinil ? Le mécanisme exact par lequel le modafinil agit n'est pas clair, bien qu'on pense qu'il agit sur le SNC. Il contient 100 milligrammes de l'ingrédient actif modafinil et peut être pris immédiatement avant ou 2 à 3 heures après le sommeil, car le même dosage peut être efficace dans chaque cas. Des modifications de la posologie pendant la phase de titration du traitement peuvent être nécessaires et doivent être effectuées lentement et avec l'aide du médecin. Le modafinil est le plus couramment utilisé pour traiter les deux troubles du sommeil énumérés ci-dessus. Le fonctionnement de Modafinil n'est pas encore entièrement compris. Le modafinil agit dans le cerveau pour augmenter la quantité et la durée d'activité des neurones et augmente le nombre de récepteurs de la dopamine dans le cerveau. Il réduit le temps nécessaire pour s'endormir. De plus, le modafinil est un stimulant qui agit directement dans le cerveau plutôt que de stimuler les glandes surrénales, et n'est donc pas associé aux effets secondaires respiratoires, cardiaques ou neurologiques de stimulants comme la caféine et les amphétamines. Certains des premiers traitements de la maladie impliquaient la pyridoxine, une vitamine B6, mais celle-ci est tombée en disgrâce en raison de preuves insuffisantes pour étayer son efficacité.

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