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#7
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#8
Le modafinil soulage également les symptômes des troubles du sommeil tels que les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil, en aidant à augmenter la vigilance tout au long de la journée. Le traitement peut durer toute la vie et des augmentations de dosage peuvent être nécessaires pour prévenir la somnolence. Chez les patients qui ne sont pas narcoleptiques, le modafinil agit pour bloquer les effets des médicaments stimulants qui peuvent exacerber l'apnée du sommeil, tels que le méthylphénidate et les médicaments de type amphétamine. La dose recommandée varie, mais lorsqu'une personne utilise le médicament pour la première fois, elle peut être prise sans tenir compte du moment de la dose de la veille, alors que des doses plus importantes sont souvent prises après le dîner ou lorsque le corps est le plus endormi. Comme pour de nombreux médicaments, l'administration une fois par jour est préférable à l'administration plusieurs fois par jour afin de réduire les doses hors cible. Son efficacité pour cette utilisation n'est pas claire. Le modafinil, également vendu sous le nom de marque Provigil, est un traitement de la somnolence due à la narcolepsie, des troubles du sommeil liés au travail posté et de l'apnée obstructive du sommeil. Le modafinil peut provoquer une légère euphorie, une sécheresse de la bouche, des mains moites, des palpitations cardiaques et des nausées chez certaines personnes. Le modafinil est disponible en différentes concentrations, mais il est généralement disponible sous la forme d'un seul comprimé de 100 mg qui doit être avalé entier. Le modafinil, également connu sous le nom de Provigil, Modvigil et le nom commercial Armodafinil, est un médicament sur ordonnance, en particulier un stimulant du système nerveux central (SNC). L'agonisme dopaminergique dans le cortex préfrontal a été associé à une augmentation de l'éveil chez les personnes atteintes de schizophrénie. Le modafinil agit en diminuant la latence d'endormissement, en augmentant la vigilance et en réduisant la somnolence matinale. D'autres utilisations non approuvées du modafinil comprennent le traitement du trouble déficitaire de l'attention/hyperactivité (TDAH) et l'utilisation non médicale en tant que médicament déficitaire de l'attention (TDA). Le modafinil a un impact sur une grande partie du cerveau, mais semble avoir un impact particulièrement fort sur le système lié aux messages excitateurs et inhibiteurs dans le cerveau, qui deviennent moins perturbés à mesure que le sommeil devient plus répandu. La majorité des recherches évaluant le modafinil a été réalisée chez des enfants et des adolescents atteints de TDAH. modafinil en ligne Le modafinil (Modalert, Provigil) a reçu l'approbation de l'Agence européenne des médicaments (EMA) pour traiter la somnolence diurne excessive associée à l'hypersomnie idiopathique. La formulation de modafinil approuvée par la FDA contient l'ingrédient actif 100 mg de base libre de méthylphénidate (MPH-F). De nombreux effets secondaires ont été rapportés avec l'utilisation du modafinil, avec moins d'effets secondaires ressentis à des doses plus élevées. Le modafinil est également utilisé comme agent adjuvant dans le traitement de la maladie de Parkinson. La stimulation de ces neurones peut provoquer plusieurs types d'effets sur les nerfs, les muscles et les glandes. L'utilisation chronique ou à long terme du modafinil peut entraîner une pharmacodépendance. Le modafinil contient une molécule inerte (ne provoque pas de réponse dans le corps) appelée homosapien. La concentration plasmatique maximale du modafinil et de la caféine est à peu près la même, mais le métabolisme du modafinil est presque 10 fois plus rapide que celui de la caféine. Il peut également être utilisé comme stimulant cognitif pour ceux qui souffrent de "brouillard cérébral". Une étude de 2006 a montré une moyenne de 14,7 heures d'éveil pour les sujets prenant 200 mg de modafinil et de 17 heures pour ceux prenant 400 mg, bien que le besoin de sommeil n'ait pas été pris en compte. En tant que médicament sur ordonnance, il n'est disponible qu'avec l'autorisation d'un médecin. Il n'est pas indiqué pour le traitement de la somnolence associée à la narcolepsie.

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#9
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#10
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