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06-25-2023, 01:39 AM
(This post was last modified: 06-25-2023, 01:40 AM by Le Modafinil .)
Les Г©tudes impliquant Modafinil en combinaison avec la cocaГЇne ont eu des rГ©sultats mitigГ©s. Le modafinil est un inhibiteur d'affinitГ© moyenne, sГ©lectif et rГ©versible du transporteur rГ©gulГ© par la dopamine, DAT1, situГ© dans la membrane prГ©synaptique. La quantitГ© de mГ©dicament utilisГ©e peut devoir ГЄtre ajustГ©e chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques. Le modafinil est sГ©lectif pour le sous-type de rГ©cepteur dopaminergique D4 (D4DR) et le sous-type de rГ©cepteur D1 (D1DR) dans une moindre mesure. Cependant, en ligne, vous pouvez obtenir du Modafinil dans une large gamme de dosages diffГ©rents et mГЄme Г des doses personnalisГ©es. Г‰tant donnГ© que le modafinil est mГ©tabolisГ© par la mГЄme enzyme qui dГ©compose de nombreux mГ©dicaments couramment utilisГ©s, tels que l'alcool et la cafГ©ine, il peut interagir avec l'action de ces mГ©dicaments. Les effets secondaires indГ©sirables sont similaires Г ceux d'autres stimulants, notamment des palpitations, des difficultГ©s respiratoires, de la colГЁre et de l'agitation. Il peut ГЄtre utile de connaГ®tre les mГ©dicaments qui interagissent avec Modafinil. Il est Г©galement approuvГ© pour le traitement de la somnolence diurne excessive associГ©e Г l'apnГ©e obstructive du sommeil. Des effets secondaires potentiellement mortels et d'autres effets secondaires graves peuvent survenir si la dose correcte n'est pas utilisГ©e ou si le mГ©dicament est utilisГ© pendant une pГ©riode prolongГ©e. Le modafinil semble agir en agissant sur la dopamine et en modulant les zones du cerveau impliquГ©es dans le cycle du sommeil. Il a Г©tГ© dГ©montrГ© que le modafinil se lie fortement aux rГ©cepteurs de l'histamine et a une faible affinitГ© pour les rГ©cepteurs sigma-1 et sigma-2 et une affinitГ© significative pour les rГ©cepteurs alpha-2 et dopamine-2. Certains des effets rapportГ©s dans la littГ©rature sont la somnolence, les Г©tourdissements, les maux de tГЄte, l'instabilitГ©, les difficultГ©s de concentration et les nausГ©es.
modiodal 100 mg Il existe des preuves que le modafinil peut également réduire la latence du sommeil. Il s'agit d'un médicament sympathomimétique non amphétamine qui ressemble à une substance semblable à un neurotransmetteur appelée acétylcholine. Des événements cardiovasculaires dose-dépendants, y compris l'hypertension, les arythmies cardiaques et l'angine de poitrine, ont été signalés chez des personnes suivant un régime de modafinil à long terme. Bien que cette classification repose en grande partie sur des informations sur la façon dont le médicament est utilisé et son comportement dans un cadre contrôlé, l'American Society of Pharmacology and Experimental Therapeutics ne recommande pas de programmer Modafinil jusqu'à ce que davantage de recherches soient menées pour déterminer correctement son efficacité et son utilisation appropriée. Le modafinil peut également augmenter ou diminuer la tension artérielle. Alternativement, il peut augmenter la sérotonine dans le noyau périventriculaire de l'amygdale, un élément clé du rythme circadien qui organise le sommeil et l'éveil chez les mammifères. Le modafinil réduit la somnolence diurne excessive sans nuire aux performances chez les personnes normales en bonne santé ou les personnes en mauvaise santé qui ont une condition particulière, comme la narcolepsie ou l'apnée obstructive du sommeil. Le transporteur de la dopamine est responsable de la recapture de la dopamine, ce qui aide à éliminer cet acide aminé des synapses, ou des jonctions entre les neurones. Le mécanisme d'action du modafinil n'est pas entièrement compris, mais semble améliorer l'éveil et diminuer la somnolence. Alors que la FDA a approuvé le médicament pour l'insomnie, les informations de prescription officielles du médicament ont appelé à une évaluation simultanée du temps de sommeil total pour garantir le respect du temps de sommeil prescrit. Le modafinil est disponible aux États-Unis en vente libre et est vendu sous le nom de marques Alertec, Efexor, Evex, Frio, Modafinil et Provigil. Produit par la société française Thales, la société mère d'origine de la société pharmaceutique française Lafon, le Modafinil est un mélange racémique de deux énantiomères. Il est important de noter la valeur de la dose de 150 mg. Le modafinil est un stimulant du système nerveux central, qui est théorisé pour stimuler les voies de l'adénosine dans le cerveau. Le modafinil est un inhibiteur de la recapture de la norépinéphrine et de la dopamine.
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Les comprimés de modafinil sont blancs à blanc cassé et se présentent sous la forme d'un cercle, d'un carré, d'une étoile ou d'un triangle. Les doses doivent être soigneusement contrôlées. Les études ont rapporté des résultats contradictoires concernant l'effet du modafinil sur la cognition et son efficacité s'est avérée non concluante chez les personnes présentant des déficits cognitifs. Le modafinil doit être pris au moins 2 heures avant l'activité prévue. Le modafinil est métabolisé à 95 % par le foie. Le modafinil est un stimulant du SNC. En conséquence, il semble être très efficace dans sa capacité à améliorer l'attention et la vigilance, ainsi qu'à améliorer la mémoire et la motivation. La recherche indique que Modafinil agit en augmentant l'action de la dopamine, un neurotransmetteur. Le modafinil s'est avéré efficace pour soulager les symptômes du trouble bipolaire. Le modafinil a été développé à l'origine pour traiter un trouble connexe, le trouble du sommeil lié au travail posté, dans lequel ce trouble de la phase de sommeil circadien est associé à une somnolence pendant la journée due au travail de nuit. Des rapports antérieurs montrent également que le modafinil pourrait être utilisé pour traiter la mauvaise qualité du sommeil ou le manque d'énergie associé à la dépression et à d'autres troubles de l'humeur. Cette augmentation de la durée du sommeil est une conséquence de la modulation du peptide hypocrétine/orexine régulateur du sommeil dans l'hypothalamus. La dose maximale de modafinil ne doit pas dépasser 450 mg par jour. Certaines personnes prenant du modafinil ont connu une augmentation des niveaux de mélatonine, ce qui a provoqué des troubles du sommeil non menaçants chez certaines personnes. Il a été trouvé pour augmenter l'éveil et les capacités cognitives.
modiodal 100 mg C'est la forme qui devient Г©ventuellement disponible pour la liaison avec les transporteurs de la dopamine et de la noradrГ©naline, ainsi qu'avec le transporteur de la sГ©rotonine. La FDA a dГ©clarГ© qu'il s'agissait d'un projet et qu'aucun dГ©tail n'a Г©tГ© publiГ©. D'autres troubles du sommeil, tels que le trouble des mouvements pГ©riodiques des jambes, peuvent amener les personnes Г bouger leurs jambes ou leurs bras involontairement pendant leur sommeil et peuvent perturber les habitudes de sommeil normales. C'est parfois une composante du programme en 12 Г©tapes des Alcooliques Anonymes. Le modafinil, comme la cafГ©ine et la dextroamphГ©tamine, est un dГ©rivГ© mГ©thylГ© de l'amphГ©tamine. Dans de rares cas, les personnes peuvent dГ©velopper des hallucinations (par exemple, percevoir que des personnes ou des animaux se dГ©placent autour d'objets ou s'engagent dans des activitГ©s qui ne se produisent pas rГ©ellement). Le modafinil n'est actuellement pas utilisГ© dans le traitement du TDAH. Les changements cognitifs peuvent inclure des Г©tourdissements, des maux de tГЄte, une fatigue inhabituelle et de la colГЁre. Le modafinil semble Г©galement fonctionner en rГ©duisant la libГ©ration de certains neurotransmetteurs, notamment l'adГ©nosine, la noradrГ©naline, le GABA, la 5-HT et Г©ventuellement l'histamine. Le modafinil est Г©galement utilisГ© pour amГ©liorer l'Г©veil chez certaines personnes qui ne souffrent pas de somnolence diurne excessive. Le modafinil est gГ©nГ©ralement utilisГ© une fois par jour le matin. Le modafinil bloque Г©galement la recapture de la dopamine, en bloquant le transporteur de la dopamine.
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