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06-24-2023, 01:05 AM
(This post was last modified: 06-24-2023, 01:07 AM by Le Modafinil .)
Il est rapidement absorbГ© aprГЁs administration orale et rapidement distribuГ© dans la plupart des tissus et fluides. Le modafinil peut ГЄtre pris seul mais est souvent combinГ© avec d'autres stimulants pour obtenir un effet plus fort. Il n'est pas recommandГ© chez les patients souffrant d'insuffisance hГ©patique ou rГ©nale. Pour de meilleurs rГ©sultats, il est pris dans l'heure qui prГ©cГЁde le coucher. Le modafinil n'est pas approuvГ© pour une utilisation comme activateur cognitif aux Г‰tats-Unis. Les premiГЁres Г©tudes chez l'homme ont Г©tГ© rГ©alisГ©es par un groupe de l'UniversitГ© de Pennsylvanie. Le modafinil est disponible Г la fois sous forme de mГ©dicament sur ordonnance et de mГ©dicament gГ©nГ©rique aux Г‰tats-Unis. Comme d'autres produits de modafinil, l'ingrГ©dient actif est un mГ©lange racГ©mique d'Г©nantiomГЁres - deux molГ©cules Г image miroir de la mГЄme formule chimique - qui sont mГ©tabolisГ©es diffГ©remment. Il est couramment utilisГ© pour traiter la somnolence chez les personnes atteintes de narcolepsie ou de troubles du sommeil liГ©s au travail postГ©. La quantitГ© de mГ©dicament utilisГ©e peut devoir ГЄtre ajustГ©e chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques.
provigil france Le modafinil est un médicament synthétique développé par une société pharmaceutique française et est le seul ingrédient actif de plusieurs préparations de modafinil. L'une des raisons pour lesquelles le Modafinil a été utilisé comme somnifère est ses propriétés dopaminergiques. Le modafinil est un médicament stimulant qui agit sur la dopamine pour augmenter le niveau d'éveil dans le cerveau. Ce produit n'est pas approuvé pour cet usage et ne peut pas résoudre de tels problèmes. Cela suggère qu'il peut également être un agent améliorant l'attention. vigilance. Le modafinil n'est pas recommandé pour les personnes sujettes aux palpitations cardiaques ou aux arythmies. Le brevet détenu par cette société a expiré en 1990. L'ingrédient actif du modafinil est le Modaferon AF, un médicament à libération prolongée contre la fatigue et la somnolence. Il est considéré comme un inhibiteur partiel de la neurotransmission de la dopamine et est également un agoniste allostérique du récepteur alpha-2A. Il a été découvert pour la première fois au début des années 1970 par les neuroscientifiques français Michel Jouvet et les laboratoires Lafon, cependant, la structure exacte du modafinil n'a été déterminée qu'en 1987.
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Un test utilisГ© pour Г©valuer la capacitГ© mГ©tabolique d'un individu pour la clairance hГ©patique de la drogue utilise l'isoenzyme acГ©tyl-para-aminophГ©nol, qui se trouve sous forme conjuguГ©e en tant que constituant du mГ©tabolite hydroxy-modafinil. Le monohydrate de chlorhydrate de modafinil et le citrate de modafinil sont respectivement ses sels de chlorhydrate et de citrate. Le modafinil est un antagoniste de l'adГ©nosine qui agit en augmentant l'adГ©nosine extracellulaire, activant ainsi les rГ©cepteurs inhibiteurs de l'adГ©nosine A1. Son distributeur est Sun Pharmaceutical Industries. La quantitГ© de mГ©dicament utilisГ©e peut devoir ГЄtre ajustГ©e chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques. Il est vendu entre autres sous la marque Provigil. Bien qu'il ait Г©tГ© utilisГ© hors AMM comme prГ©tendu activateur cognitif pour amГ©liorer l'Г©veil dans des Г©tudes animales et humaines, la recherche sur son efficacitГ© pour cette utilisation n'est pas concluante. Le mГ©dicament contient 200 mg de modafinil et la posologie recommandГ©e est de 200 Г 400 mg chaque matin. L'ingrГ©dient actif du modafinil est le 2-[(diphГ©nylmГ©thyl)sulfinyl]-acГ©tamide, Г©galement connu sous le nom de 2-diphГ©nylsulfinyl acГ©tamide, et souvent abrГ©gГ© en Dipsan. On prГ©tend qu'il Г©tait autrefois le seul mГ©dicament stimulant cognitif disponible sur le marchГ©, mais il est depuis tombГ© en disgrГўce Г mesure que de nouveaux mГ©dicaments sont apparus. La stimulation de la dopamine augmente les niveaux de dopamine, un neurotransmetteur dans le cerveau, qui est impliquГ© dans la rГ©gulation de l'appГ©tit, de la motricitГ©, de la motivation et de la concentration. D'autres utilisations du modafinil incluent la neuro-amГ©lioration, en tant qu'amplificateur cognitif. Pour cette indication, la dose de 100mg Г©quivaut Г 1,5mg Г 2,5mg de modafinil. Il peut Г©galement ГЄtre disponible en tant que mГ©dicament gГ©nГ©rique dans d'autres pays.
provigil france Il s'appelle R-modafinil aux Г‰tats-Unis mais modafinil au Royaume-Uni. De rares rГ©actions dermatologiques graves peuvent survenir chez les personnes prГ©sentant des prГ©dispositions gГ©nГ©tiques et plus frГ©quemment chez les patients pГ©diatriques. C'est un stimulant du systГЁme nerveux central (SNC). Il a Г©tГ© approuvГ© avec un avertissement sur le risque de dГ©pendance si le mГ©dicament est pris frГ©quemment. Le modafinil ne doit pas ГЄtre pris avec d'autres stimulants tels que la cocaГЇne, car ceux-ci peuvent provoquer des effets secondaires dГ©sagrГ©ables ou dangereux. Les enfants peuvent Г©prouver plus d'effets secondaires que les adultes. Dans la narcolepsie, les signes et symptГґmes liГ©s au trouble du sommeil sont grandement amГ©liorГ©s par le modafinil, et la plupart des patients peuvent arrГЄter d'utiliser le mГ©dicament. Cela conduit Г un Г©veil accru et Г un Г©veil plus long que le sommeil naturel. Le deuxiГЁme mГ©canisme passe par l'inhibition des rГ©cepteurs de la membrane plasmique de la sГ©rotonine dans la glande pinГ©ale, qui est une zone riche en sГ©rotonine. Le modafinil agit en augmentant les niveaux des neurotransmetteurs dopamine et noradrГ©naline dans le cerveau et en rГ©duisant la somnolence, la fatigue et la somnolence causГ©es par la diminution des niveaux des neurotransmetteurs. La posologie peut ГЄtre augmentГ©e Г 6 et 8 mg.
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