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[Le Modafinil]

Le modafinil est un inhibiteur sГ©lectif de la recapture de la noradrГ©naline (NARI), un antagoniste des rГ©cepteurs adrГ©nergiques alpha-1 et un inhibiteur faible du transporteur de la dopamine (DATI). Le modafinil est connu pour amГ©liorer diverses affections et a Г©tГ© utilisГ© pour traiter un certain nombre de troubles, notamment les troubles du sommeil, le trouble dГ©ficitaire de l'attention avec hyperactivitГ©, la toxicomanie et les lГ©sions cГ©rГ©brales traumatiques lГ©gГЁres. Les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques ne doivent utiliser cette dose que sous Г©troite surveillance mГ©dicale. En 2014, il a Г©tГ© rГ©vГ©lГ© que les National Institutes of Health avaient examinГ© une Г©tude de 2012 suggГ©rant que le modafinil pouvait amГ©liorer la concentration et la mГ©moire chez les jeunes adultes en bonne santГ©. L'alanine aminotransfГ©rase est une enzyme hГ©patique qui rГ©gule la biosynthГЁse des acides aminГ©s. C'est le seul stimulant approuvГ© par la FDA, principalement utilisГ© pour traiter la somnolence excessive associГ©e Г  la narcolepsie. Modafinil n'est pas approuvГ© pour toutes les utilisations. La dose initiale de modafinil peut ГЄtre augmentГ©e Г  400 mg. Le mГ©dicament agit en agissant comme un stimulant du systГЁme nerveux central. Il est dГ©rivГ© de l'arbre Erythroxylum coca, qui a d'abord Г©tГ© utilisГ© comme stimulant par les peuples autochtones d'AmГ©rique du Sud. ComparГ© Г  l'amphГ©tamine, le modafinil a une durГ©e d'action plus longue. Sa formule molГ©culaire est C26H26Cl2N2O et son point de fusion est de 120-121 В°C. Le modafinil n'est pas approuvГ© par la Food and Drug Administration (FDA) pour une utilisation comme activateur cognitif aux Г‰tats-Unis, mais il a Г©tГ© utilisГ© aux Г‰tats-Unis hors AMM. ou acheter modafinil Le modafinil peut Г©galement empГЄcher la dГ©gradation d'un autre neurotransmetteur, la dopamine. Il en rГ©sulte une augmentation du niveau d'acГ©tylcholine qui est supposГ©e favoriser la somnolence. Dans ses premiГЁres Г©tudes, on pensait que le modafinil fonctionnait en imitant l'effet de l'adГ©nosine endogГЁne. Les symptГґmes de somnolence extrГЄme peuvent inclure un sommeil excessif, l'insomnie et l'endormissement en conduisant. Le comprimГ© enrobГ© est disponible en comprimГ©s de 10 mg, 200 mg, 400 mg et 800 mg. La dose peut varier considГ©rablement en fonction de ce pour quoi le patient est prescrit. Le rГ©veil brutal dГ» Г  un trouble du sommeil sous-jacent entraГ®ne un cycle de sommeil chaotique. Le modafinil peut ГЄtre pris seul mais est souvent combinГ© avec d'autres stimulants pour obtenir un effet plus fort. Il est recommandГ© d'augmenter progressivement la dose de modafinil pour aider Г  prГ©venir tout effet secondaire possible. Pour l'insomnie chronique, qui rГ©siste au traitement, les individus doivent ГЄtre traitГ©s avec 300 mg la nuit et 100 Г  200 mg le jour.

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Le modafinil a Г©galement une faible nootropique (renforcement du cerveau) propriГ©tГ©s. LГ , ils diminuent l'activitГ© des neurotransmetteurs dopamine et noradrГ©naline. Aucune Г©tude n'a Г©tГ© faite pour prouver que l'amГ©lioration cognitive se produit par ce mГ©canisme. Le modafinil est utilisГ© dans le traitement des troubles du sommeil. Il a Г©tГ© trouvГ© pour augmenter l'Г©veil et les capacitГ©s cognitives. La formulation Г  libГ©ration prolongГ©e est destinГ©e Г  rГ©duire les effets secondaires de la somnolence et de la nervositГ©. Le modafinil a Г©tГ© approuvГ© par la Food and Drug Administration (FDA) des Г‰tats-Unis en 1998. La narcolepsie avec cataplexie peut survenir en rГ©ponse Г  certains Г©vГ©nements (par exemple, la lumiГЁre, la dГ©shydratation ou le stress). Le modafinil peut avoir plus d'effet sur les zones alpha (lobes frontaux) et bГЄta (cervelet et thalamus) du cerveau, qui sont responsables d'activitГ©s plus ciblГ©es et contrГґlГ©es. Sa prescription dans ces indications est approuvГ©e par la Food and Drug Administration (FDA) aux Г‰tats-Unis. Il a une taille de particule infГ©rieure Г  un micromГЁtre, ce qui est supГ©rieur Г  la taille approximative d'une seule molГ©cule d'eau, ce qui le fait apparaГ®tre comme un solide cristallin. Le modafinil 400 mg peut ГЄtre utilisГ© dans des situations oГ№ le sommeil est considГ©rablement plus perturbateur, et Г©galement lorsqu'il est nГ©cessaire de dГ©marrer ou de maintenir la vigilance pendant une durГ©e considГ©rable. Un arrГЄt soudain peut entraГ®ner des effets dГ©sagrГ©ables tels que des maux de tГЄte, des Г©tourdissements ou des Г©tourdissements et des troubles du sommeil. ou acheter modafinil On ne sait pas si le modafinil a un effet sur les niveaux de rГ©cepteurs de l'adГ©nosine. Le modafinil affecte principalement l'activitГ© mentale et la pensГ©e, mais il existe Г©galement un potentiel pour une gamme d'autres effets secondaires. Des recherches supplГ©mentaires sont nГ©cessaires pour Г©tablir ses avantages, ainsi que son innocuitГ© dans diverses populations et doses. La quantitГ© de mГ©dicament utilisГ©e peut devoir ГЄtre ajustГ©e chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques. Le modafinil pour adultes est gГ©nГ©ralement pris une fois par jour avec un repas, au coucher et est gГ©nГ©ralement pris avec ou aprГЁs le petit-dГ©jeuner, avant de se coucher. Le modafinil se prend par voie orale. Le modafinil est frГ©quemment utilisГ© pour traiter la somnolence excessive associГ©e Г  la narcolepsie et pour amГ©liorer l'Г©veil chez ceux qui travaillent par quarts. Il est possible que le mГ©dicament agisse en augmentant la production de dopamine dans le cerveau, augmentant ainsi les effets dopaminergiques de ces mГ©dicaments. Il agit Г©galement comme un agent neuroprotecteur et a des actions antidГ©pressives et antipsychotiques. Il a Г©tГ© dГ©veloppГ© dans le but de traiter des conditions caractГ©risГ©es par une somnolence et une fatigue excessives.

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