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(This post was last modified: 07-02-2023, 06:31 AM by wolfsone .)
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Le nom В« Modafinil В» vient des premiГЁres lettres de Michel Jouvet et des Laboratoires Lafon, la sociГ©tГ© qui a inventГ© le composГ©. Le mГ©canisme d'action exact des nootropiques n'est pas compris, mais le cerveau produit de la dopamine et le modafinil semble augmenter les quantitГ©s de dopamine, ce qui devrait ГЄtre bГ©nГ©fique pour les personnes ayant des problГЁmes d'attention, de concentration et de motivation. Les effets secondaires courants sont rГ©pertoriГ©s dans le tableau suivant. Entre 2003 et 2005, Baycol, une autre marque de Provigil, a Г©tГ© commercialisГ©e aux Г‰tats-Unis et au Canada sous la marque Aricept. Le principal effet du modafinil est une sensation d'Г©veil et souvent une vigilance accrue. Contactez votre mГ©decin pour discuter des avantages et des risques du produit. Les patients prenant des mГ©dicaments qui inhibent le CYP3A4 (par exemple le kГ©toconazole) peuvent prГ©senter une diminution des effets secondaires. Cette Г©tude particuliГЁre n'a pas Г©tГ© couronnГ©e de succГЁs et en 1986, le post-doctorant de Jouvet, Michel Legrand, a commencГ© Г l'utiliser sur des personnes Г la place. Les rГ©actions cutanГ©es telles que les Г©ruptions cutanГ©es allergiques et l'urticaire (urticaire) sont parmi les effets secondaires les plus frГ©quemment observГ©s du modafinil, bien que la majoritГ© des personnes ne les ressentent pas. Le nom chimique du modafinil est 7-(benzhydrylsulfinyl)1,2-dihydro-2,2-dimГ©thyl-1-pyrrolidinone.
modafinil belgique Dans le corps, le modafinil est dГ©composГ© par le mГ©tabolisme hГ©patique. Le rГ©sultat est une augmentation de la dopamine, augmentant ainsi l'excitation dans le cortex prГ©frontal. Il est disponible sous forme de comprimГ©s Г libГ©ration immГ©diate de 200 mg et 400 mg. La dose initiale typique est de 200 Г 300 mg par jour. Comment le modafinil doit-il ГЄtre utilisГ© ? Modafinil est pris par voie orale et est pris au besoin. De nombreuses Г©tudes contrГґlГ©es contre placebo ont Г©tudiГ© son utilisation pour amГ©liorer la vigilance chez des volontaires sains, ainsi que pendant le travail postГ© et la privation de sommeil. Il est liГ© Г l'albumine sГ©rique. Le modafinil traverse la barriГЁre hГ©mato-encГ©phalique et atteint des concentrations dans le cerveau environ 10 fois supГ©rieures aux taux sГ©riques. Il a montrГ© qu'il avait un effet positif dans les domaines de la cognition, de la mГ©moire et de la concentration, bien qu'il y ait moins de littГ©rature pour soutenir son utilisation pour amГ©liorer ces aspects de la fonction cognitive que pour la "simple" vigilance. Le modafinil a Г©galement des effets nootropiques et anti-apoptotique. Des rapports d'effets secondaires graves (y compris des rГ©actions allergiques potentiellement mortelles) chez certaines personnes dans des Г©tudes cliniques ont conduit Г des avertissements pour l'utilisation du modafinil. Ils ont tendance Г ГЄtre plus vifs que les images vues sur un Г©cran de tГ©lГ©vision.
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