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12-02-2022, 07:27 PM
(This post was last modified: 12-02-2022, 07:28 PM by Modiodal Modalert .)
La forme Г libГ©ration immГ©diate se prend Г tout moment de la journГ©e. Il stimule le systГЁme nerveux central et rГ©duit la somnolence, permettant de se concentrer et de se rГ©veiller en se sentant rafraГ®chi. Comme d'autres stimulants, il semble interfГ©rer avec le cycle du sommeil dans le cerveau. Le modafinil est un dГ©rivГ© de la phГ©nylГ©thylamine et est structurellement similaire Г l'amphГ©tamine et au mГ©thylphГ©nidate mais sans leurs effets euphorigГЁnes. Le mГ©dicament est rapidement distribuГ© Г tous les tissus du corps. Cependant, le modafinil ne semble pas provoquer l'euphorie ou affecter le corps de la mГЄme maniГЁre que les autres stimulants. Il n'est pas clair si Modafinil est ou peut ГЄtre utilisГ© pour amГ©liorer la fonction cognitive ou maintenir la fonction cognitive. L'humeur est restГ©e inchangГ©e. Le modafinil a Г©tГ© testГ© dans des essais cliniques humains sur des placebos et contre la cafГ©ine et n'a pas montrГ© de meilleurs effets d'amГ©lioration que les placebos, bien qu'il ait augmentГ© les performances diurnes. Ce mГ©dicament ne doit pas ГЄtre pris par une personne souffrant d'arythmie, d'hypertension importante ou d'hypertrophie ventriculaire gauche. Le mГ©canisme d'action du Modafinil n'est pas complГЁtement compris, bien qu'on pense qu'il fonctionne comme un stimulant du systГЁme nerveux central qui amГ©liore la capacitГ© Г rester Г©veillГ©. Il peut ГЄtre utilisГ© pour lutter contre la fatigue associГ©e au travail postГ©, comme celle liГ©e Г l'entretien des compagnies aГ©riennes ou des routes, et pour les insomnies non liГ©es au travail postГ©. Le modafinil est chimiquement similaire aux amphГ©tamines et est principalement utilisГ© pour amГ©liorer l'Г©veil. Le modafinil semble stimuler les zones du cerveau impliquГ©es dans le cycle du sommeil.
Acheter Modafinil Sans Ordonnance Le modafinil peut potentialiser ou augmenter les effets des amphГ©tamines. Bien que le mГ©canisme exact ne soit pas clair, le principal composant pharmacologique du modafinil est la cafГ©ine, car il a une forte affinitГ© pour les rГ©cepteurs de l'adГ©nosine, qui sont notamment prГ©sents dans les cellules de type 1 sensibles Г la cafГ©ine du noyau gГ©niculГ© latГ©ral dorsal (dLGN) et dans la rГ©tine. Il contient l'ingrГ©dient actif modafinil. Le modafinil est inclus sous forme de boГ®te tournante aux Г‰tats-Unis. Il peut rГ©duire la probabilitГ© d'Г©pisodes de sommeil liГ©s au travail postГ©, qui peuvent causer des problГЁmes cardiovasculaires et autres chez les travailleurs postГ©s. Le modafinil interagit avec la voie de la noradrГ©naline, moins efficacement que la dopamine, mais plus que les autres stimulants. Une action de type amphГ©tamine a conduit Г spГ©culer que le modafinil est similaire Г d'autres mГ©dicaments stimulants. Le modafinil, qui est une substance contrГґlГ©e aux Г‰tats-Unis et dans plusieurs autres parties du monde, est disponible en vente libre aux Г‰tats-Unis, ainsi que dans de nombreuses rГ©gions d'Europe et d'Asie. Г‰tant donnГ© que le mГ©dicament est un mГ©lange racГ©mique de deux isomГЁres optiques, chaque isomГЁre a un effet pharmacologique diffГ©rent. La formulation du comprimГ© est un comprimГ© dispersible dans l'eau blanc Г blanc cassГ© avec une fine section au centre du comprimГ© contenant le mГ©dicament actif rГ©el. Cependant, les rГ©sultats en matiГЁre de prГ©vention et de traitement de la dГ©pression ont Г©tГ© moins concluants. Le modafinil se prend par voie orale. Le mГ©canisme d'action exact du modafinil n'est pas bien connu. Le modafinil est utilisГ© pour traiter la somnolence due Г la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil, ainsi que le modafinil.
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Des Г©tudes animales ont montrГ© qu'il peut augmenter l'Г©veil et les comportements liГ©s Г l'Г©veil. MГ©canisme d'action : Les effets antidГ©presseurs du modafinil sont dus Г sa capacitГ© Г stimuler les rГ©cepteurs de l'adГ©nosine A2A. Cependant, la batterie CogState a Г©tГ© utilisГ©e dans un certain nombre d'Г©tudes sur le modafinil, ce qui en fait un bon outil Г utiliser lors des tests d'amГ©liorations cognitives. La dose d'entretien habituelle est de 100 mg (norme britannique). Ces derniГЁres annГ©es, il est devenu une "drogue intelligente" populaire pour augmenter la productivitГ© et la vigilance, et son utilisation Г cette fin a Г©tГ© appelГ©e "l'amytal du travailleur". Le nom chimique du modafinil est 2-(2-benzylpyrrolidin-3-yl)-[1,2,4]triazolo[4,3-b]pyridazine et son poids molГ©culaire est de 372,69. Modafinil diffГЁre structurellement en ayant un groupe phГ©nyle supplГ©mentaire attachГ© Г l'azote Г l'extrГ©mitГ© de la molГ©cule. Le modafinil est un inhibiteur spГ©cifique de l'enzyme hydrolase des amides d'acides gras (FAAH), qui dГ©grade les endocannabinoГЇdes (anandamide et 2-arachidonoylglycГ©rol), les principaux neurotransmetteurs inhibiteurs naturels dans le cerveau. Il n'a pas Г©tГ© approuvГ© pour le traitement du TDAH et les Г©tudes n'ont pas montrГ© d'efficacitГ© pour le traitement du TDAH. Dans une Г©tude de 2014, les chercheurs ont dГ©couvert que l'effet du modafinil Г©tait moindre lorsque les gens Г©taient "encouragГ©s Г apprendre Г mieux dormir". Il est difficile de dГ©terminer la quantitГ© de Modafinil prise, car une personne peut prendre plus que prescrit en regardant dans le flacon. Le modafinil a Г©tГ© utilisГ© pour traiter les troubles du rythme circadien du sommeil tels que le syndrome de retard de phase du sommeil (DSPS), qui se caractГ©rise par des difficultГ©s Г s'endormir, de la fatigue et un manque d'Г©veil diurne.
Acheter Modafinil Sans Ordonnance Il est possible que le mГ©dicament agisse en augmentant la production de dopamine dans le cerveau, augmentant ainsi les effets dopaminergiques de ces mГ©dicaments. Les effets secondaires du modafinil peuvent inclure des maux de tГЄte, des troubles du sommeil, des nausГ©es et des Г©tourdissements. Le modafinil est Г©galement utilisГ© pour amГ©liorer l'Г©veil chez certaines personnes souffrant d'affections qui provoquent une somnolence chronique, comme la sclГ©rose en plaques. Le modafinil est Г©galement utilisГ© comme complГ©ment nutritionnel commercialisГ© comme stimulant de l'Г©veil ou des performances cognitives, ou pour augmenter l'endurance physique ou comme aide Г la perte de poids. Il est librement soluble dans l'acГ©tone, l'acГ©tonitrile, l'acГ©tate d'Г©thyle, l'Г©thanol, l'Г©ther et les solutions aqueuses. Le mГ©tabolisme in vitro avec le CYP3A4 recombinant a montrГ© qu'au niveau thГ©rapeutique, seulement 10 % du mГ©dicament parent est mГ©tabolisГ©. Le modafinil est chimiquement une mГ©thylphГ©nylpropylamine. C'est Г©galement une forme optiquement pure dextrogyre de la cafГ©ine, ce qui la distingue pharmacologiquement de la cafГ©ine. Ceci est suivi d'une redistribution rapide, la majeure partie du composГ© d'origine Г©tant Г©liminГ©e dans l'urine. La FDA a publiГ© une dГ©claration indiquant qu '"il n'y avait aucune preuve d'Г©vГ©nements indГ©sirables graves dans le nombre limitГ© d'Г©tudes cliniques sur le modafinil. Il n'est pas distribuГ© dans le systГЁme nerveux central et n'a pas de mГ©tabolites actifs. Chaque pilule individuelle contient 100 mg de mГ©dicament, ce qui Г©quivaut Г une dose moyenne de 160 mg prise sur une pГ©riode de deux Г quatre heures.
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