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C'est un domaine de recherche complexe, et l'efficacitГ© des somnifГЁres n'est pas prouvГ©e Г long terme. Le modafinil affecte les transporteurs de la dopamine et de la noradrГ©naline. La dose recommandГ©e de modafinil pour le traitement de la somnolence excessive associГ©e Г la narcolepsie est de 200 mg trois fois par jour. La narcolepsie peut provoquer une somnolence diurne. В» Les personnes ayant des antГ©cГ©dents de certains troubles du sommeil et de maladies psychotiques doivent demander un dossier Г jour ou complet de leurs symptГґmes avant de prendre du modafinil. La dose approuvГ©e de modafinil est de 100 Г 200 mg pris au moins deux heures avant le coucher avec de la nourriture. Le modafinil est principalement mГ©tabolisГ© par l'enzyme hГ©patique CYP3A4. Une dose de 200 Г 400 mg, selon les individus, peut ГЄtre prise en deux prises fractionnГ©es. Il s'agit d'un nootropique commercialisГ© sous le nom de Provigil, et il a Г©tГ© prouvГ© qu'il amГ©liore l'efficacitГ© de l'apprentissage et de la mГ©moire chez les personnes en bonne santГ©. Cela se produit dans les Г©tudes sur les humains et les animaux, et on pense qu'il contribue Г ses effets favorisant l'Г©veil. Cette dГ©cision est importante pour le modafinil, car de nombreuses preuves prГ©cliniques et cliniques suggГЁrent qu'il amГ©liore la mГ©moire, l'attention et les fonctions cognitives. On pense que le principal isomГЁre actif du modafinil est l'Г©nantiomГЁre R du modafinil et que le (S)-modafinil est un isomГЁre inerte pharmacologique qui est mГ©tabolisГ© par le foie en son dГ©rivГ© actif, ou mГ©tabolite. On pense que le modafinil agit comme un stimulant sur le systГЁme dopaminergique du corps, dont il a Г©tГ© dГ©montrГ© qu'il ralentit le cycle de sommeil du corps. Il n'est pas recommandГ© chez les personnes ayant des antГ©cГ©dents d'arythmie, d'hypertension, d'insuffisance rГ©nale ou d'hypertrophie ventriculaire gauche.
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