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La cafГ©ine augmente les niveaux de dopamine dans le cerveau. Certaines personnes peuvent Г©galement ressentir une diminution de l'appГ©tit, une diminution de la libido et de la fatigue. Les effets secondaires courants comprennent les maux de tГЄte, les troubles du sommeil et les nausГ©es. D'autres effets secondaires incluent des nausГ©es, des maux de tГЄte, des troubles du sommeil et une diminution de la libido. Le gГЁne du rГ©cepteur est liГ© aux rГ©cepteurs de la dopamine. Le modafinil a Г©tГ© dГ©veloppГ© pour augmenter l'Г©veil chez les personnes souffrant de troubles du sommeil. Son utilisation a Г©tГ© dГ©crite comme un traitement non invasif pour les personnes atteintes de narcolepsie. Le modafinil est un composГ© chimique actif. Cependant, des effets secondaires sont possibles si le mГ©dicament est utilisГ© de maniГЁre inappropriГ©e ou Г fortes doses. Il ne semble pas ГЄtre un traitement efficace pour la somnolence excessive due Г l'apnГ©e obstructive du sommeil. En raison de ses propriГ©tГ©s stimulantes, le modafinil provoque une augmentation de la pression artГ©rielle, de la frГ©quence cardiaque et de la glycГ©mie. Modafinil Ordonnance Le mГ©dicament peut Г©galement ГЄtre pris dans le cadre d'essais cliniques. En plus d'amГ©liorer l'activitГ© et le comportement diurnes, le modafinil peut Г©galement soulager les symptГґmes de somnolence. Le modafinil est gГ©nГ©ralement pris avant le coucher. Des Г©tudes ont notГ© que l'effet du modafinil dГ©pend de la dose. Cependant, le modafinil ne provoque pas de somnolence, mais augmente plutГґt l'Г©veil et l'activitГ© cГ©rГ©brale. Il est autorisГ© au Canada. Il a Г©tГ© approuvГ© pour un usage mГ©dical aux Г‰tats-Unis en 1998. Le modafinil contient une molГ©cule inerte (ne provoque pas de rГ©ponse dans le corps) appelГ©e homosapien. C'est un agoniste partiel des rГ©cepteurs de la sГ©rotonine et un antagoniste des rГ©cepteurs de la dopamine Г longue durГ©e d'action. En rГЁgle gГ©nГ©rale, une dose initiale de 100 Г 200 mg par jour est considГ©rГ©e comme sГ»re. Des Г©tudes chez le rat montrent que les niveaux de norГ©pinГ©phrine dans le cerveau culminent dans les 5 Г 15 minutes suivant l'administration de modafinil et que les niveaux de dopamine augmentent dans les 30 minutes. Il s'agit d'un stimulant du systГЁme nerveux qui a Г©tГ© utilisГ© hors AMM comme prГ©tendu activateur cognitif pour amГ©liorer l'Г©veil dans des Г©tudes animales et humaines, mais les preuves de son efficacitГ© en tant qu'activateur cognitif restent anecdotiques.
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