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Les effets secondaires courants comprennent la somnolence, les maux de tГЄte, les nausГ©es et les troubles du sommeil. L'intoxication mГ©dicamenteuse associГ©e Г l'utilisation de stimulants du SNC peut ГЄtre aussi dangereuse que l'utilisation d'opioГЇdes. Il en rГ©sulte un spectre diffГ©rent d'effets secondaires possibles. De plus, le modafinil favorise l'Г©veil en activant les voies cГ©rГ©brales noradrГ©nergiques et dopaminergiques. Le modafinil se prend par voie orale. Il est important de prendre le mГ©dicament exactement tel que prescrit. Le modafinil est gГ©nГ©ralement pris Г jeun. Il agit en augmentant les niveaux de dopamine dans le cerveau, ce qui affecte l'Г©veil. Le modafinil est Г©troitement liГ© Г l'amphГ©tamine, mais les deux mГ©dicaments ont une action nettement diffГ©rente. En cas de somnolence diurne excessive, il peut soulager les symptГґmes dГ©bilitants. Chez certains patients, une dose de modafinil le soir est une meilleure option de traitement. Modafinil a Г©tГ© dГ©veloppГ© Г l'origine par Michel Jouvet, puis par les Laboratoires Lafon. Le modafinil agit en augmentant le nombre de rГ©cepteurs de la dopamine disponibles et en bloquant l'enzyme acГ©tylcholinestГ©rase. Le modafinil se prГ©sente sous la forme de comprimГ©s de 100 mg, 200 mg et 300 mg, ainsi que de suspension buvable de 100 mg et 200 mg. La CPT (durГ©e de puissance constante) la formulation de modafinil est prise une seule fois par jour, vers midi. Modiodal L'arbre Swietenia pousse nativement au Malawi et au Mozambique. Le modafinil a Г©tГ© utilisГ© hors AMM pour augmenter les performances mentales chez les adultes en bonne santГ© et pour traiter le trouble dГ©ficitaire de l'attention avec hyperactivitГ© (TDAH). п»їLe modafinil est un stimulant utilisГ© pour traiter la somnolence due Г la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil. Les mГ©canismes prГ©cis par lesquels le modafinil affecte le SNC ne sont pas encore compris. Le modafinil est rapidement absorbГ© aprГЁs prise orale avec un Tmax d'environ 3 Г 6 heures. Il est Г©galement utilisГ© hors AMM pour certaines dГ©pressions et parfois pour l'insomnie. Le modafinil est un nouveau stimulant ayant des actions sur le neurotransmetteur dopamine. Le modafinil est utilisГ© pour traiter divers troubles du sommeil et la fatigue diurne, tels que les troubles du sommeil liГ©s au travail postГ© (SWSD), l'apnГ©e du sommeil, la narcolepsie et la cataplexie; les effets secondaires Г court terme peuvent inclure des maux de tГЄte, des troubles du sommeil et des nausГ©es. Environ 85 % de la dose est absorbГ©e par voie orale. Le modafinil a Г©tГ© introduit pour la premiГЁre fois sous le nom de Sipuleucel-T par Dendreon, qui a Г©tГ© commercialisГ© pour son effet sur le nombre croissant de cellules du systГЁme immunitaire appelГ©es lymphocytes infiltrant la tumeur dans le cancer de la prostate.
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