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11-16-2022, 04:15 PM
(This post was last modified: 11-16-2022, 04:15 PM by France Medicine .)
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Le modafinil semble avoir des effets sГ©rotoninergiques et il stimule et inhibe la libГ©ration de GABA. Le modafinil peut ГЄtre classГ© comme В« inhibiteur de la recapture В» ou В« agoniste de la dopamine В». Modafinil est fourni sous forme de comprimГ© qui est placГ© sous la langue et avalГ©. Le modafinil est un stimulant cГ©rГ©bral prescrit pour le traitement de l'insomnie (troubles du sommeil) et de la somnolence diurne excessive. Le modafinil est quelque peu controversГ© en raison de son utilisation dans le traitement des personnes souffrant d'un manque de sommeil, car son efficacitГ© en tant qu'amplificateur de la cognition reste Г prouver. Le modafinil est mГ©tabolisГ© Г 95 % par le foie. Le modafinil appartient Г la classe des mГ©dicaments stimulants. Le modafinil a Г©tГ© approuvГ© comme traitement de la somnolence due Г la narcolepsie en 1995 par la Food and Drug Administration (FDA) des Г‰tats-Unis. Malheureusement, la recherche n'a pas abouti Г des conclusions concluantes sur l'innocuitГ© et l'efficacitГ©. Le modafinil est un inhibiteur d'affinitГ© moyenne, sГ©lectif et rГ©versible du transporteur rГ©gulГ© par la dopamine, DAT1, situГ© dans la membrane prГ©synaptique. MГ©canisme d'action: Le modafinil augmente l'Г©veil, diminue la durГ©e du sommeil lent, rГ©duit la durГ©e du sommeil Г mouvements oculaires non rapides (NREM) et retarde ou attГ©nue la transition de l'Г©veil au sommeil NREM. Le modafinil est un stimulant unique qui est une substance favorisant l'Г©veil lorsqu'il est utilisГ© comme mГ©dicament d'appoint pour les troubles de la somnolence, tels que la narcolepsie et les troubles du sommeil liГ©s au travail postГ©.
Modiodal Sans Ordonnance Le modafinil est également disponible sur ordonnance aux États-Unis. Le traitement par le modafinil peut être bénéfique pour certains cas de somnolence associés à une surmédication ou à une sous-médication avec des antidépresseurs, des sédatifs, des antihistaminiques et des antipsychotiques. L'une des formes de modafinil est le modafinil xr, une version à libération prolongée une fois par jour du médicament qui permet de rester éveillé pendant 24 heures. Comme ses homologues, armodafinil et Nuvigil, le modafinil est produit par des pharmacies de préparation et commercialisé par une grande variété de sociétés, souvent à des prix différents selon les points de vente. Au Royaume-Uni, il peut être acquis avec une ordonnance en vente libre s'il est commandé auprès d'une pharmacie en ligne réputée. La FDA a approuvé Provigil, ou modafinil aux États-Unis, pour une utilisation dans le traitement des troubles du sommeil liés au travail posté (SJS). Le groupe méthyle bloque le site de reconnaissance des récepteurs de l'adénosine, c'est ainsi que cela fonctionne. Le modafinil peut agir comme un faible inhibiteur de la monoamine oxydase. Le modafinil était commercialisé en France depuis 1994 sous la marque Provigil, qui est la dénomination officielle en France, et il a été homologué aux Etats-Unis en mars 1998, sous la marque Armodafinil. Le modafinil augmente l'activité de la voie noradrénergique du locus coeruleus, qui est associée à la vigilance, l'attention, l'énergie et l'éveil. Le modafinil est disponible sous différentes formes de dosages, selon la façon dont il sera pris. Il est possible d'ajouter de la N-Acétyl L-Cystéine (NAC) pour augmenter le bénéfice et améliorer la tolérabilité pendant les périodes de sevrage du médicament et l'utilisation pendant une plus longue période sans ressentir de somnolence. Le modafinil est un médicament sur ordonnance sans benzodiazépine utilisé pour traiter la somnolence associée à la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. Le modafinil augmente également les niveaux d'adénosine monophosphate cyclique (AMPc) dans certains neurones et augmente la libération de neurotransmetteurs, les messagers chimiques qui permettent aux cellules nerveuses de communiquer entre elles.
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