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Bien qu'elle ne soit pas recommandée comme stimulant cognitif, la crème soulage l'insomnie modérée à sévère. Le modafinil a tendance à être bien toléré, bien que son utilisation ne soit pas recommandée chez les personnes souffrant de troubles hépatiques ou rénaux sous-jacents. Le modafinil inhibe la recapture de la sérotonine et de la noradrénaline par les vésicules présynaptiques et la libération de ces neurotransmetteurs par le neurone présynaptique est ainsi réduite. Cela signifie qu'il agit en compétition avec l'adénosine, un neurotransmetteur inhibiteur, pour se lier au récepteur de l'adénosine A1. Il fonctionne chez les personnes qui manquent modérément de sommeil ou qui se sentent très somnolentes. Il a été démontré que le modafinil inhibe la libération d'oxyde nitrique et en présence d'oxyde nitrique in vitro. Une utilisation prolongée peut entraîner une dépendance et une tolérance. Des médicaments similaires sont également disponibles en Asie et au Moyen-Orient. Le modafinil est vendu sous forme de prescription et en vente libre et est accompagné d'une étiquette d'avertissement. Le nouveau composé était administré à des narcoleptiques qui étaient devenus somnolents pendant la journée et commençaient à présenter une cataplexie. deux heures avant le coucher. Le modafinil est un agent favorisant l'éveil sans potentiel d'abus, bien que des utilisations supplémentaires non liées à ses propriétés favorisant l'éveil puissent se produire.
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