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Contrairement aux amphétamines, il ne garde pas l'utilisateur éveillé. Le modafinil ne semble pas avoir d'effets significatifs sur l'humeur de ceux qui le prennent, ni n'augmente la quantité d'acétylcholine dans le cerveau, et par conséquent, il ne semble pas avoir de potentiel d'abus, bien qu'il ne soit pas clair comment l'utilisation à long terme de la drogue peut contribuer à la dépendance physique. Les effets secondaires graves comprennent les réactions allergiques, y compris l'anaphylaxie et le syndrome de Stevens-Johnson. Le risque de réactions allergiques peut également être plus élevé chez les personnes ayant des antécédents de psychose. Semblable à la caféine, qui augmente la vigilance, le modafinil augmente la vigilance sans produire d'effet stimulant. Il peut également diminuer l'efficacité de l'orlistat, un médicament pour le traitement de la perte de poids, en améliorant son propre métabolisme. L'ingrédient actif du modafinil est le modafinil ou le 7-chloro-8-hydroxy-3-(2-méthyl-2-phényl-éthyl)-1-méthyl-2,4-dihydro-pyrazol[3,2-c]-pyridine . En augmentant l'apport de dopamine et en augmentant les niveaux du neurotransmetteur dans le cortex préfrontal et le cortex cérébral du cerveau, davantage de neurones sont susceptibles de se déclencher, améliorant ainsi l'éveil. Jusqu'à présent, le modafinil est l'un des deux médicaments qui a fait l'objet du plus grand nombre d'études de recherche. Modafinil est un mélange racémique et a une formule empirique de C12H11NOS. Le modafinil n'est efficace que s'il est pris juste avant le cycle de sommeil. Cependant, certains médecins soutiennent que l'utilisation quotidienne de plus de 400 mg par jour peut être nocive. Le modafinil peut être administré par voie orale ou sous forme de spray nasal. Le modafinil a une biodisponibilité orale élevée (F = 95 %) et est bien absorbé. Le modafinil inhibe l'activité enzymatique CYP2C19, ce qui signifie qu'il ne doit pas être administré avec le clopidogrel. Provigil En Maroc Il n'y a pas de dosage spécifique pour le modafinil. Une association avec l'hypertension peut être dose-dépendante. Le modafinil se présente sous forme de comprimés de deux dosages différents, 25 mg et 200 mg, ainsi que d'une gélule. Il est disponible aux États-Unis, au Royaume-Uni, en Inde, au Bangladesh, en Australie, au Brésil, au Canada, en Nouvelle-Zélande, en Norvège, au Pakistan, au Portugal et en Afrique du Sud. Le modafinil stimule également la production d'oxyde nitrique par les cellules endothéliales vasculaires, ce qui favorise la vasodilatation et donc abaisse la tension artérielle. Le modafinil est un substrat du transporteur de cations organiques 2 (OCT2). Cela devrait être pris avant d'aller au lit. Le modafinil est généralement pris sous forme de comprimé de 200 mg à 400 mg. Cette étude a conclu que la pémoline n'était pas un activateur cognitif efficace. Le modafinil peut être pris sans égard à la nourriture ou à l'heure de la journée. Le modafinil n'est plus approuvé par la Food and Drug Administration (FDA) des États-Unis pour le travail posté, l'agence recommandant à la place des options de traitement alternatives. Les symptômes de la narcolepsie ont tendance à devenir plus fréquents au cours des deux premières semaines d'utilisation du modafinil, à atteindre un pic, puis à se stabiliser à une fréquence réduite. Les taux sanguins de modafinil sont généralement augmentés lorsqu'ils sont pris avec un repas gras. Des effets cognitifs ont été observés chez deux personnes privées de sommeil ayant reçu une seule dose de 200 mg de modafinil.
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