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Le médicament s'est avéré sûr chez les personnes atteintes d'insuffisance rénale; cependant, il n'est pas recommandé chez les personnes atteintes de cirrhose et celles souffrant de dysfonctionnement hépatique et rénal. Le modafinil est connu pour interagir avec la dopamine, qui est un neurotransmetteur naturel dans le cerveau. Dans certains pays, le (S)-modafinil est disponible sous forme de médicament délivré uniquement sur ordonnance, contrôlé et surveillé (par exemple en France et au Royaume-Uni). Cependant, les inhibiteurs de la MAO et d'autres inhibiteurs de la monoamine oxydase réduisent la MAOA, entraînant une réduction des monoamines cérébrales. En tant que médicament stimulant du SNC, le modafinil a été mis à disposition pour le traitement de la somnolence due à la narcolepsie, des troubles du sommeil liés au travail posté et de l'apnée obstructive du sommeil. Il n'est pas recommandé chez les personnes souffrant d'arythmie, d'hypertension artérielle importante ou d'hypertrophie ventriculaire gauche. Le modafinil est fortement lié aux protéines et stable dans le plasma et les tissus. Si vous êtes dans une situation où vous devez rester vigilant, par exemple lorsque vous conduisez, le modafinil est plus efficace le soir ou la nuit, lorsque vous êtes le plus fatigué. Ceci est réalisé par une action spécifique sur les récepteurs de la dopamine D2 dans l'hypothalamus et d'autres parties du cerveau. Le modafinil est utilisé pour traiter la fatigue liée au travail posté, la somnolence due à la narcolepsie et l'apnée obstructive du sommeil. Dans une étude sur des volontaires masculins en bonne santé, l'utilisation de 10 mg de modafinil pendant six jours a considérablement amélioré leur capacité à détecter un signal dans le bruit de fond et a amélioré leur mémoire de travail par rapport au placebo. Cela augmente la concentration de dopamine dans la synapse, ce qui améliore l'efficacité des neurotransmetteurs au niveau des récepteurs post-synaptiques. Il n'y a pas d'information sur le profil pharmacocinétique et pharmacodynamique de la base libre de Modafinil. Ou Trouver Modafinil Le modafinil a obtenu sa première approbation par la FDA américaine aux États-Unis en 1998 sous le nom de Provigil pour le traitement de la somnolence diurne excessive associée à la narcolepsie et à d'autres troubles. Il a également été démontré que le modafinil stimule la libération de dopamine dans le cerveau. Il est également disponible sous forme liquide. Le modafinil peut être associé à d'autres médicaments qui affectent les niveaux de certains neurotransmetteurs, notamment le bupropion et le méthylphénidate. Le modafinil a été prescrit hors AMM comme antagoniste non compétitif du N-méthyl-D-aspartate (NMDA) pour traiter les troubles cognitifs de la maladie de Parkinson, et il existe des preuves suggérant qu'il pourrait améliorer la fonction visuospatiale chez les personnes atteintes de la maladie d'Alzheimer. Fabriqué par Roche, Vertex Pharmaceuticals et Canyon Pharmaceuticals et commercialisé sous le nom de Provigil par Pfizer, le modafinil est administré par voie orale. Les effets secondaires rares mais graves comprennent des réactions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, des hallucinations chez les personnes ayant des antécédents de psychose et des réactions dermatologiques graves. Les comprimés contiennent le médicament actif Modalert®. Le modafinil est approuvé pour les patients âgés de 10 à 60 ans. De plus, c'est un inhibiteur sélectif de la recapture de la noradrénaline dans le SNC. Le médicament modafinil agit en se liant aux sites récepteurs de la dopamine du cerveau. Le modafinil a été développé dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon. Le modafinil peut provoquer des effets secondaires indésirables comme des maux de tête, des étourdissements, de l'anxiété, de l'irritabilité, des nausées et de l'insomnie.
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