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12-05-2022, 08:55 AM
(This post was last modified: 12-05-2022, 08:55 AM by Modiodal Modalert.)
La majoritГ© du modafinil vendu aux Г‰tats-Unis est fabriquГ© par la sociГ©tГ© franГ§aise H. La quantitГ© de mГ©dicament utilisГ©e peut devoir ГЄtre ajustГ©e chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques. Il s'agit de la dose "standard" pour l'insomnie et les troubles du sommeil liГ©s au travail postГ©. Le modafinil est vendu sous forme de comprimГ© et de solution buvable sous les marques Provigil et MST. Le modafinil s'est avГ©rГ© efficace pour le traitement des personnes atteintes de narcolepsie, oГ№ il peut ГЄtre utilisГ© pour diminuer la somnolence, amГ©liorer l'Г©veil et rГ©duire la cataplexie chez les personnes atteintes de narcolepsie de type cataplexie. Il a un manque de potentiel addictif et un dГ©veloppement de tolГ©rance minimal. Aux Г‰tats-Unis, il est indiquГ© pour le traitement de la narcolepsie, des troubles du sommeil liГ©s au travail postГ© et de l'apnГ©e obstructive du sommeil. Modafinil est administrГ© par voie orale et est pris une fois par jour. Ses mГ©canismes d'action pharmacologiques sont diffГ©rents de ceux des autres stimulants et comprennent une action en tant qu'antagoniste des rГ©cepteurs alpha-1, un agoniste des rГ©cepteurs de la dopamine D1 et de la dopamine D2 et une amГ©lioration de la transmission du glutamate dans le cerveau. Le mГ©dicament modafinil est disponible sous diffГ©rentes formes et doses pour faciliter l'utilisation. Les effets secondaires courants comprennent des problГЁmes de sommeil, une sensation de nervositГ©, des nausГ©es et une sensation de fatigue plus importante que d'habitude. L'agent actif du modafinil est le R-modafinil, qui est 3 fois plus efficace que le S-modafinil plus faible. Il ne semble pas altГ©rer la sensibilitГ© des rГ©cepteurs ou provoquer une dГ©sensibilisation des rГ©cepteurs. Le modafinil est un mГ©dicament stimulant. Modiodal Modafinil Le modafinil manque Г©galement de nombreux potentiels de dГ©pendance et d'abus associГ©s Г d'autres stimulants tels que la cocaГЇne et l'amphГ©tamine. de psychose. Des Г©tudes sur des participants Г des essais cliniques qui ont reГ§u du modafinil jusqu'Г 400 mg/jour sur une pГ©riode de 4 semaines ont rapportГ© des amГ©liorations similaires dans les tests de vigilance, d'attention et d'Г©veil Г celles observГ©es avec au moins 150 mg de modafinil par jour. Le modafinil est Г©galement souvent utilisГ© pour traiter les personnes souffrant d'insomnie, car il aide les personnes Г rester Г©veillГ©es toute la nuit. En tant qu'agent sГ©datif-hypnotique, le mГ©dicament est un inhibiteur sГ©lectif de la recapture dopaminergique, un processus neurochimique responsable de l'accumulation post-synaptique du neurotransmetteur dopamine. L'ingrГ©dient actif du modafinil est le citrate de modafinil. Le mГ©dicament est un dГ©rivГ© acГ©tamide de la phГ©nГ©thylamine avec un groupe acГ©tyle sur l'azote de l'acГ©tamide et l'Г©nantiomГЁre chiral ® du mГ©dicament. Le modafinil a relativement peu d'effets secondaires en raison de cette action directe et a l'avantage supplГ©mentaire d'ГЄtre sans danger pendant la grossesse. Les personnes qui souffrent de troubles du travail postГ© (Г©galement appelГ©s somnolence excessive ou sommeil excessif et souvent appelГ© trouble dГ©ficitaire du sommeil) utilisent souvent Modafinil pour lutter contre la somnolence en raison de la nature circadienne des cycles de sommeil et d'Г©veil. Le modafinil est une amine tertiaire aromatique qui se lie spГ©cifiquement au rГ©cepteur de l'adГ©nosine A1 dans le cortex frontal du cerveau, permettant ainsi la sГ©crГ©tion de plus de dopamine. les processus mentaux. Les patients peuvent avoir des difficultГ©s Г dГ©terminer leur propre capacitГ© Г conduire ou Г utiliser des machines aprГЁs avoir pris du modafinil, et il peut ГЄtre utile de consulter leur mГ©decin. peut ГЄtre pris deux fois par jour. Modafinil est chimiquement dГ©crit comme 2-[(diphГ©nylmГ©thyl)-sulfinyl]acГ©tamide, 2-[(diphГ©nylmГ©thyl)sulfinyl]acГ©tyl naphtalГЁne-2-ol.
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En tant que stimulant, Modafinil agit en augmentant les niveaux de neurotransmetteurs dans le cerveau. Les rГ©cepteurs de la dopamine jouent Г©galement un rГґle dans l'intГ©gration des signaux hormonaux, ce qui pourrait expliquer pourquoi le modafinil augmente les niveaux de testostГ©rone et de cortisol. Les gГ©nГ©riques de modafinil contiennent les mГЄmes ingrГ©dients actifs que le nom de marque et peuvent ГЄtre remplacГ©s par la version de marque. Ceux-ci sont gГ©nГ©ralement lГ©gers et surviennent chez moins de 1 % des personnes prenant du modafinil. Il a une demi-vie de 9 Г 11 heures et est principalement excrГ©tГ© dans l'urine. Le modafinil est un stimulant du systГЁme nerveux central qui agit en stimulant directement le cerveau pour favoriser l'Г©veil. Certains chercheurs avaient rapportГ© que le modafinil pouvait amГ©liorer la fonction cognitive, suggГ©rant un potentiel d'abus. L'activation des rГ©cepteurs de la dopamine se produit dans les rГ©gions dorsales du cerveau. Plus de 30 ans de recherche sur le Modafinil ont donnГ© peu de preuves qu'il s'agit d'un activateur cognitif efficace malgrГ© les affirmations contraires. Le mГ©dicament peut Г©galement ГЄtre pris dans le cadre d'essais cliniques. En raison du fonctionnement du systГЁme de rota-box, ceux qui souhaitent acheter le mГ©dicament peuvent acheter les deux types de rota-box, l'un avec 200 mg de modafinil et l'autre avec 400 mg de modafinil. Modiodal Modafinil Le modafinil est une phГ©nГ©thylamine synthГ©tique, un stimulant et un coupe-faim. Pour Г©viter les problГЁmes liГ©s Г l'interaction avec l'alcool, les patients ne doivent pas non plus prendre de modafinil s'ils prennent des benzodiazГ©pines, des barbituriques, des antidГ©presseurs ou des amphГ©tamines. Il est Г©galement appelГ© Provigil, Generikum® Modafinil, Modalefenol et Modralift. Le modafinil se prend par voie orale. Les effets secondaires graves peuvent inclure des rГ©actions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antГ©cГ©dents de psychose. Une autre thГ©orie soutient que le Modafinil agit sur les neurones noradrГ©nergiques, ou les neurones qui contiennent de la noradrГ©naline. L'un des effets secondaires du modafinil est l'augmentation de l'Г©veil et de la vigilance, bien que des doses plus faibles puissent minimiser cet effet. Le modafinil est un inhibiteur sГ©lectif irrГ©versible de l'enzyme DAOA, une enzyme naturellement prГ©sente dans le corps humain. Certains utilisateurs ont Г©tГ© signalГ©s Г utiliser deux comprimГ©s de 100 mg par jour. La dose recommandГ©e pour les personnes atteintes de narcolepsie sГ©vГЁre, comme la cataplexie, est de 200 Г 400 mg. Les rГ©sultats ont montrГ© qu'aprГЁs quatre semaines de prise de 200 mg par jour, le score aux tests d'intelligence s'est amГ©liorГ© chez 57% des enfants atteints d'un trouble du spectre autistique. L'ingrГ©dient actif du modafinil est le sulfoxyde de modafinil, ou R-modafinil. Contrairement Г des substances telles que l'amphГ©tamine et le mГ©thylphГ©nidate, ses effets ne semblent pas avoir d'impact immГ©diat sur la tension artГ©rielle, le rythme cardiaque ou la respiration.
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